Technology Listings


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Combination Therapy for Increasing Venetoclax Sensitivity in Multiple Myeloma
Application Marker and co-therapy that inhibits succinate dehydrogenase to increase patient response to venetoclax. Key Benefits Co-therapy increases MM sensitivity to venetoclax treatment. Identifies patients who will respond to venetoclax therapy. Market Summary Multiple Myeloma (MM) is a cancer of plasma cells responsible for making antibody...
Published: 6/18/2019       Inventor(s): Malathy (mala) Shanmugam, Richa Bajpai
Assay for Non-Nucleoside Inhibitors of the Measles and Nipah Viruses
Application A cell-based assay to screen for inhibitors of the measles virus (MV). Highly active compounds have been identified and analogs have been synthesized and evaluated. Key BenefitsPotent (sub-nM range), non-peptidic, non-nucleosidic compounds. Robust, cell-based, high-throughput screening assay. Technical Summary Vaccination serves as the only...
Published: 10/18/2016       Inventor(s): Richard Plemper, James Snyder, Aiming Sun
A Nutritional Therapy for Autism/Apraxia and Malabsorption
ApplicationAn elemental dietary supplement for treating autism, apraxia and malabsorption syndrome to reverse and avoid nutritional deficiencies. Key BenefitsProvides a complete elemental dietary supplement with the proper dosage of nutrients for children with the syndrome of allergy, apraxia, and malabsorption. Potential treatment for neuro & motor...
Published: 2/17/2015       Inventor(s): Claudia Morris
Combination Drug Treatment for Neoplasms Associated with Tuberous Sclerosis
Application Combination of rapamycin and imatinib for the treatment of neoplasms associated with tuberous sclerosis (TS). Key Benefits Combined therapy shows 97% decrease in tumor volume in mouse model of TS compared to vehicle treatment. Dual therapy blocks two major signaling pathways implicated in TS. Market Summary Tuberous sclerosis (TS) is...
Published: 9/18/2012       Inventor(s): Jack Arbiser
Noscapine Analogs as a Potential Cancer Therapeutic
Application Noscapine analogs that incorporate 9-aminonoscapine for use as a cancer treatment. Key Benefits Has higher tubulin activity than noscapine. Induces apoptosis selectively in ovarian and T-cell lymphoma tumor cells that are already drug-resistant. Market Summary Ovarian cancer affects approximately 13 of every 100,000 women and about 80...
Published: 8/22/2012       Inventor(s): Harish Joshi, Ritu Aneja, Suryan Vangapandu
Drosophila Model of Galactosemia
Application Whole animal genetic model for Galactosemia. Fly model can be used to test efficacy of novel therapeutic interventions. Genetic system enables screening for suppressors and/or genetic modifiers of Galactosemia. Key Benefits First whole-animal genetic model to study GALT and GALE function. Only model that mimics acute...
Published: 4/14/2011       Inventor(s): Ken (Kenneth) Moberg, Judith Fridovich-Keil, Rebecca Sanders, Jennifer Sefton, Rebekah Kushner, Emily Ryan, Kerry Garza
Compounds for Suppressing Fragile X Premutation rCGG Repreat-Mediated Toxicity
Application Compounds for the treatment of Fragile X-associated tremor/ataxia syndrome. Key Benefits 11 known, FDA approved drugs identified that reduced rCGG-mediated lethality to a certain degree. 3 of these drugs also rescued locomotion deficits. Technical Summary Fragile X syndrome (FXS) is the most common inheritable form of cognitive disability...
Published: 2/24/2011       Inventor(s): Peng Jin, Abrar Qurashi
Food Lists for Nutritional Management of Metabolic Disorders
ApplicationsBooklets which provide a reference guide for nutritional management of rare genetic diseases.Technical SummaryA majority of inherited metabolic disorders affect children and adults worldwide. Many metabolic disorders require special dietary therapy and monitoring by a team of physicians, nurses, genetic counsellors, social workers, and dietitians...
Published: 4/29/2009       Inventor(s): Rani Singh