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Precision Protein Repair Platform for Missense Mutations
Application
This technology enables targeted chemical correction of missense mutations in proteins using a modular heterotrifunctional molecule platform.
Key Benefits
Restores protein function by chemically mimicking healthy amino acid side chains.
Modular toolkit allows rapid customization for diverse protein targets.
Validated across multiple...
Published: 11/12/2025
Contributor(s): Monika Raj
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Protein Polymers for Organelle Engineering
Application
Protein polymers enabling engineering of human membraneless organelles.
Key Benefits
Versatile applications across immunotherapy, cell therapy, and other therapeutic modalities.
High biocompatibility with minimal reactivity with endogenous molecules.
Deployable for organelle-level functionalization of human cells.
Market Summary
Proteins...
Published: 11/7/2025
Contributor(s): Felipe Quiroz, Ian Sicher, Spencer Hayes, Maria Giraldo-Castaño, Mariell Pascual, Alexa Avecilla
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MKK3/MYC Protein-Protein Interaction Inhibitor Overcomes Resistant Non-Small Cell Lung Cancer
Application
A therapeutic use for SGI-1027 in the treatment of Osimertinib-resistant non-small cell lung cancer (NSCLC).
Key Benefits
The MKK3/MYC protein-protein interaction inhibitor SGI-1027 effectively decreases MYC levels in Osimertinib-resistant NSCLC cell lines.
The combination of SGI-1027 with Osimertinib offers synergistic benefits over...
Published: 10/15/2025
Contributor(s): Andrey Ivanov, Haian Fu, Shi-Yong Sun, Zhen Chen
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