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Choledocholithiasis (Gallstones in Bile) Prediction Algorithm iOS App
Application
A mobile app to predict gallstones in the bile duct in children.
Key Benefits
Accurate, non-invasive prediction of gallstones in the bile duct.
Based on readily available patient information.
Market Summary
Choledocholithiasis or bile stones in the gal duct is one of the most common medical conditions leading to surgical...
Published: 9/29/2022
Contributor(s): Reuven Zev Cohen, Alvin Freeman, Sheng Zhang
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Predicting Treatment Response in Patients with Spinal Muscular Atrophy (SMA)
Application
Prognostic model predicts treatment response to nusinersen (Spinraza®) in patients with spinal muscular atrophy.
Key Benefits
A prediction model using baseline CHOP-INTEND, IL-8, fractalkine, and MCP-1 accurately predicts CHOP-INTEND outcomes in children treated with nusinersen
The model can also be incorporated into future therapeutic...
Published: 4/5/2023
Contributor(s): William Hu, Sumit Verma
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Vision Test for Non-Verbal Children
Application
Vision testing for non-verbal children, the hearing impaired, and non English-speaking population.
Key Benefits
Simplifies vision testing for non-verbal children.
Does not require any verbal communication to be used effectively.
Technical Summary
While traditional eye charts are often effective, they rely on verbal communication...
Published: 8/19/2022
Contributor(s): Amy Hutchinson, Caroline Cromelin, Cindy Harrington
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3D Model for Analysis and Treatment Planning of Vascular Disease
Application
A patient-specific, 3D model of pulmonary atresia for surgical planning.
Key Benefits
Patient-specific model.
Allows for accurate surgical planning.
Enables new anastomosis procedure.
Market Summary
Pulmonary atresia (PA), ventricular septal defect (VSD) with major aortopulmonary collateral arteries (MAPCAs) is a rare congenital...
Published: 12/6/2022
Contributor(s): Vahid Serpooshan, Holly Bauser-Heaton, Martin Tomov
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Galectin-9 Directed CAR T-cells for Overcoming Resistance to Chemotherapy in Hematological Malignancies
Application
Anti-human Galectin-9-directed chimeric antigen receptor (CAR) T-cells for treatment of hematological malignancies (B-ALL, T-ALL, and DLBCL) in normal, overweight, and obese patients.
Key Benefits
Can be used as a stand-alone or in-combination product to treat patients with hematological malignancies, particularly overweight and obese...
Published: 5/4/2023
Contributor(s): Curtis Henry, Miyoung (Mi-Young) Lee, Sunil Raikar, Jamie Hamilton, Anthony Ross
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Combination Therapy to Treat Pediatric Brain Tumor
Application
Combination therapy (inhibition of STAT3 and YB-1) to treat medulloblastoma.
Key Benefits
Drug combination targets cancer stem cells.
Increased apoptosis of cancer cells compared to current chemotherapeutic agents.
Market Summary
Medulloblastoma (MB) is the most common cancerous brain tumor that affects children and survival rates...
Published: 5/4/2023
Contributor(s): Tobey John MacDonald, Anna Kenney, James Felker, Abhinav Dey
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TGFβR3-based Biomaterial to Treat Bone Damage
Application
PEG-MAL (Poly(ethylene glycol) methyl ether maleimide) polymer gel composition containing soluble TGFβ3R or embedded with modified TGFβ3R over-expressing cells for bone growth and repair therapy.
Key Benefits
Targets a non-BMP2 signaling pathway to improve BMP signaling.
Avoids complications associated with BMP2.
Market...
Published: 12/6/2022
Contributor(s): Steven Goudy
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Parent Training Curriculum to Manage Food Selectivity in Children with Autism
Application
Parent-mediated intervention, titled the Autism Managing Eating Aversions and Limited variety (MEAL) Plan, to reduce mealtime disruptive behavior and expand dietary diversity in young children with autism spectrum disorders.
Key Benefits
Hands-on parent training based intervention.
Reduces parental stress while developing a child’s...
Published: 8/22/2022
Contributor(s): William Sharp, Teresa (T.) Burrell, Rashelle Berry
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Beta Blocker Isomers as Angiogenesis Inhibitors
Application
β-blocker inactive form of propranolol for treatment of angiogenic disease.
Key Benefits
Reduced side-effects, such as low blood pressure and low blood sugar.
Increased anti-angiogenic activity compared to the active isoform.
Market Summary
Angiogenesis is the growth of blood vessels from the existing vasculature. While it...
Published: 4/5/2023
Contributor(s): Jack Arbiser
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Parent-Rated Anxiety Scale for Autism Spectrum Disorder (PRAS-ASD)
ApplicationScale/survey instrument for measuring anxiety in children with autism based upon a parent report.Key BenefitsIncludes 25-item measure for anxiety.Tested in a large-scale survey and clinical setting.Market SummaryAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social communication deficits and repetitive behavior....
Published: 4/5/2023
Contributor(s): Lawrence Scahill, Luc Lecavalier, Michael Aman, Karen Bearss
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