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Combination Therapy to Treat Pediatric Brain Tumor
Application Combination therapy (inhibition of STAT3 and YB-1) to treat medulloblastoma. Key Benefits Drug combination targets cancer stem cells. Increased apoptosis of cancer cells compared to current chemotherapeutic agents. Market Summary Medulloblastoma (MB) is the most common cancerous brain tumor that affects children and survival rates...
Published: 1/28/2020       Inventor(s): Tobey MacDonald, Anna Kenney, James Felker, Abhinav Dey
TGFβR3-based Biomaterial to Treat Bone Damage
Application PEG-MAL (Poly(ethylene glycol) methyl ether maleimide) polymer gel composition containing soluble TGFβ3R or embedded with modified TGFβ3R over-expressing cells for bone growth and repair therapy. Key Benefits Targets a non-BMP2 signaling pathway to improve BMP signaling. •Avoids complications associated with BMP2. Market Summary Whether...
Published: 9/20/2019       Inventor(s): Steven Goudy
Parent Training Curriculum to Manage Food Selectivity in Children with Autism
Application Parent-mediated intervention, titled the Autism Managing Eating Aversions and Limited variety (MEAL) Plan, to reduce mealtime disruptive behavior and expand dietary diversity in young children with autism spectrum disorders. Key Benefits Hands-on parent training based intervention. Reduces parental stress while developing a child’s...
Published: 8/29/2019       Inventor(s): William Sharp, Teresa (T.) Burrell, Rashelle Berry
Beta Blocker Isomers as Angiogenesis Inhibitors
Application β-blocker inactive form of propranolol for treatment of angiogenic disease. Key Benefits Reduced side-effects, such as low blood pressure and low blood sugar. Increased anti-angiogenic activity compared to the active isoform. Market Summary Angiogenesis is the growth of blood vessels from the existing vasculature. While it is a...
Published: 7/29/2019       Inventor(s): Jack Arbiser
Parent-Rated Anxiety Scale for Autism Spectrum Disorder (PRAS-ASD)
ApplicationScale/survey instrument for measuring anxiety in children with autism based upon a parent report.Key BenefitsIncludes 25-item measure for anxiety.Tested in a large-scale survey and clinical setting.Market SummaryAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social communication deficits and repetitive behavior....
Published: 7/8/2019       Inventor(s): Lawrence Scahill, Luc Lecavalier, Michael Aman, Karen Bearss
Biological Pacemakers as Alternatives/Adjuncts to Electronic Pacing Devices
ApplicationNon-viral gene delivery and a small molecule that converts heart muscle cells to pacemaker cells for the device-free treatment of slow heart rhythm.Key BenefitsMinimally invasive procedure provides cardiac pacing without device implant.Restores natural heart rhythm.Eliminates or reduces significant complications such as repeat surgeries for...
Published: 11/16/2018       Inventor(s): Hee Cheol Cho, Jun Li
Guide to Goals (G2G): Application for Type 1 Diabetes Management in Children
ApplicationWeb-based application for both self and clinical assessment and management of pediatric type 1 diabetes population.Key BenefitsSpecific for pediatric type 1 diabetes population.Patient involvement at point-of-care encourages patient-directed, goal-driven therapy.Provides simple, user friendly interface based on American Diabetes Association...
Published: 7/3/2017       Inventor(s): Andrew Muir, Prabhu Shankar, Michael Owens, Leanne West, Gregory Bishop, Yevgeniy Agalov
Respiratory Syncytial Virus (RSV) A2 Expressing Firefly Luciferase
ApplicationRecombinant RSV strain expressing firefly luciferase and the F & G genes from clinical strain A2001/2-20 for research and development of vaccines.Key BenefitsF & G proteins included in this strain show different behavior than those of the typical A2 strain proteins.May be adapted in a variety of assays, enabling the identification of RSV...
Published: 2/19/2017       Inventor(s): Martin Moore, Christopher Stobart
SABI: Survey for Adolescent Bullying and Isolation
Application Survey for identifying patterns of social networking and cyber bullying among adolescents. Key Benefits Identifies specific behaviors and experiences to provide a more detailed analysis of cyber bullying. Survey is anonymous and requires no protected health information. Market Summary Internet usage among adolescents has increased tremendously...
Published: 4/30/2015       Inventor(s): Taaha Shakir
A Nutritional Therapy for Autism/Apraxia and Malabsorption
ApplicationAn elemental dietary supplement for treating autism, apraxia and malabsorption syndrome to reverse and avoid nutritional deficiencies. Key BenefitsProvides a complete elemental dietary supplement with the proper dosage of nutrients for children with the syndrome of allergy, apraxia, and malabsorption. Potential treatment for neuro & motor...
Published: 2/17/2015       Inventor(s): Claudia Morris
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