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Questionnaires for Assessing the Effect of Visual Impairment on Quality of Life and Function in Children
Application
A standardized series of questions for the assessment of vision related quality of life and visual function in children and adolescents.
Key Benefits
Provides age-appropriate questions for children from ages 8-18 as an improvement to using currently available assessments geared toward adults.
Allows the subjective assessment of the...
Published: 2/13/2025
Contributor(s): Sheila Angeles-Han
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Drug Platform for L-Asparaginases for the Treatment of Leukemias
Application
A novel humanized therapeutic L-asparaginase compound to treat acute lymphoblastic leukemia (ALL) and other cancers.
Key Benefits
A novel drug discovery platform for developing asparaginase-based compounds to treat leukemias and other cancers.
The derivatives could exhibit less immunogenicity and systemic toxicity than FDA-approved...
Published: 3/28/2025
Contributor(s): Sunil Raikar, Christopher Doering, H. (Harold) Trent Spencer, Kristopher Knight, Harrison Brown
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RSV Vaccine for Infants and Children
Application
Vaccine for Respiratory Syncytial Virus (RSV) in infants and children.
Key Benefits
A novel vaccine targeting both the F and G proteins of the respiratory syncytial virus (RSV), including its variants.
Preliminary data in in mice show the vaccine induced the production of antibodies associated with preventing disease.
Potential to...
Published: 2/13/2025
Contributor(s): Larry Anderson, Binh Ha, Heying Sun
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Non-invasive Probes to Determine Efficacy of Cancer Therapies
Application
A real-time, non-invasive probe to determine the efficacy of cancer immunotherapies.
Key Benefits
Determines immunotherapy success in patients.
CAR cells can be tested before putting it back in the patients.
Simple diagnostic with readout in 30 minutes compared to 2-3 days.
Market Summary
Lymphoblastic leukemia is one of the most...
Published: 3/28/2025
Contributor(s): Anna Kellner, Khalid Salaita, Curtis Henry
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Improving Pediatric Asthma Management for Urban Families
Application
Home-based family psychoeducational intervention for low-income children with persistent asthma.
Key Benefits
Medical and psychosocial needs of patients and family members can be addressed simultaneously.
Significantly improved asthma management and caregiver stress in randomized controlled clinical trial.
Market Summary
Asthma...
Published: 2/13/2025
Contributor(s): Marianne Celano, Lisa Kobrynski, Chanda Holsey
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Engineered Biomaterials for Vascular Grafts
Application
A biomaterial to create grafts for treating babies with congenital heart diseases.
Key Benefits
A biocompatible material that can be used to reroute blood within the body.
Experimental data in animals show the material is biocompatible with no clots, thrombus, or adverse immune reactions.
Potential to be used in other cardiovascular...
Published: 2/13/2025
Contributor(s): Saimuralidhar (Murali) Padala, Jahnavi Mudigonda
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Central Line-Associated Bloodstream Infection (CLABSI) Prediction Model
Application
A predictive model of central line-association bloodstream infection (CLABSI).
Key Benefits
Specifically designed to improved predictive analysis of patients who are at risk for CLABSI.
Scored higher predictive values on average than similar predictive modeling without the hypotheses driven approach (Bidirectional LSTM with...
Published: 2/13/2025
Contributor(s): Azade Tabaie, Rishikesan (Rishi) Kamaleswaran, Evan Orenstein
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Microfluidic and Organotypic Tumor Slice Culture Drug Testing Platform for Individualized Cancer Therapy
Application
A drug combination screening/testing platform for individualized cancer therapy.
Key Benefits
Rapid screening of effective drug combination.
Integrated tumor microenvironment.
Identifying personalized therapy for individual cancer patient.
Market Summary
Traditional two-dimensional (2D) in vitro culture models for drug development...
Published: 2/13/2025
Contributor(s): Tobey John MacDonald, Anna Kenney, Abhinav Dey, YongTae (Tony) Kim
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Predicting Treatment Response in Patients with Spinal Muscular Atrophy (SMA)
Application
Prognostic model predicts treatment response to nusinersen (Spinraza®) in patients with spinal muscular atrophy.
Key Benefits
A prediction model using baseline CHOP-INTEND, IL-8, fractalkine, and MCP-1 accurately predicts CHOP-INTEND outcomes in children treated with nusinersen
The model can also be incorporated into future therapeutic...
Published: 2/13/2025
Contributor(s): William Hu, Sumit Verma
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Vision Test for Non-Verbal Children
Application
Vision testing for non-verbal children, the hearing impaired, and non English-speaking population.
Key Benefits
Simplifies vision testing for non-verbal children.
Does not require any verbal communication to be used effectively.
Technical Summary
While traditional eye charts are often effective, they rely on verbal communication...
Published: 7/30/2024
Contributor(s): Amy Hutchinson, Caroline Cromelin, Cindy Harrington
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