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Questionnaires for Assessing the Effect of Visual Impairment on Quality of Life and Function in Children
Application A standardized series of questions for the assessment of vision related quality of life and visual function in children and adolescents. Key Benefits Provides age-appropriate questions for children from ages 8-18 as an improvement to using currently available assessments geared toward adults. Allows the subjective assessment of the...
Published: 11/20/2024       Contributor(s): Sheila Angeles-Han
Drug Platform for L-Asparaginases for the Treatment of Leukemias
Application A novel humanized therapeutic L-asparaginase compound to treat acute lymphoblastic leukemia (ALL) and other cancers. Key Benefits A novel drug discovery platform for developing asparaginase-based compounds to treat leukemias and other cancers. The derivatives could exhibit less immunogenicity and systemic toxicity than FDA-approved...
Published: 11/20/2024       Contributor(s): Sunil Raikar, Christopher Doering, H. (Harold) Trent Spencer, Kristopher Knight, Harrison Brown
RSV Vaccine for Infants and Children
Application Vaccine for Respiratory Syncytial Virus (RSV) in infants and children. Key Benefits A novel vaccine targeting both the F and G proteins of the respiratory syncytial virus (RSV), including its variants. Preliminary data in in mice show the vaccine induced the production of antibodies associated with preventing disease. Potential to...
Published: 9/26/2024       Contributor(s): Larry Anderson, Binh Ha, Heying Sun
Non-invasive Probes to Determine Efficacy of Cancer Therapies
Application A real-time, non-invasive probe to determine the efficacy of cancer immunotherapies. Key Benefits Determines immunotherapy success in patients. CAR cells can be tested before putting it back in the patients. Simple diagnostic with readout in 30 minutes compared to 2-3 days. Market Summary Lymphoblastic leukemia is one of the most...
Published: 10/17/2024       Contributor(s): Anna Kellner, Khalid Salaita, Curtis Henry
Predicting Treatment Response in Patients with Spinal Muscular Atrophy (SMA)
Application Prognostic model predicts treatment response to nusinersen (Spinraza®) in patients with spinal muscular atrophy. Key Benefits A prediction model using baseline CHOP-INTEND, IL-8, fractalkine, and MCP-1 accurately predicts CHOP-INTEND outcomes in children treated with nusinersen The model can also be incorporated into future therapeutic...
Published: 11/20/2024       Contributor(s): William Hu, Sumit Verma
Vision Test for Non-Verbal Children
Application Vision testing for non-verbal children, the hearing impaired, and non English-speaking population. Key Benefits Simplifies vision testing for non-verbal children. Does not require any verbal communication to be used effectively. Technical Summary While traditional eye charts are often effective, they rely on verbal communication...
Published: 7/30/2024       Contributor(s): Amy Hutchinson, Caroline Cromelin, Cindy Harrington
3D Model for Analysis and Treatment Planning of Vascular Disease
Application A patient-specific, 3D model of pulmonary atresia for surgical planning. Key Benefits Patient-specific model. Allows for accurate surgical planning. Enables new anastomosis procedure. Market Summary Pulmonary atresia (PA), ventricular septal defect (VSD) with major aortopulmonary collateral arteries (MAPCAs) is a rare congenital...
Published: 10/28/2024       Contributor(s): Vahid Serpooshan, Holly Bauser-Heaton, Martin Tomov
Galectin-9 Directed CAR T-cells for Overcoming Resistance to Chemotherapy in Hematological Malignancies
Application Anti-human Galectin-9-directed chimeric antigen receptor (CAR) T-cells for treatment of hematological malignancies (B-ALL, T-ALL, and DLBCL) in normal, overweight, and obese patients. Key Benefits Can be used as a stand-alone or in-combination product to treat patients with hematological malignancies, particularly overweight and obese...
Published: 9/26/2024       Contributor(s): Curtis Henry, Miyoung (Mi-Young) Lee, Sunil Raikar, Jamie Hamilton, Anthony Ross
TGFβR3-based Biomaterial to Treat Bone Damage
Application PEG-MAL (Poly(ethylene glycol) methyl ether maleimide) polymer gel composition containing soluble TGFβ3R or embedded with modified TGFβ3R over-expressing cells for bone growth and repair therapy. Key Benefits Targets a non-BMP2 signaling pathway to improve BMP signaling. Avoids complications associated with BMP2. Market...
Published: 7/30/2024       Contributor(s): Steven Goudy
Parent Training Curriculum to Manage Food Selectivity in Children with Autism
Application Parent-mediated intervention, titled the Autism Managing Eating Aversions and Limited variety (MEAL) Plan, to reduce mealtime disruptive behavior and expand dietary diversity in young children with autism spectrum disorders. Key Benefits Hands-on parent training based intervention. Reduces parental stress while developing a child’s...
Published: 7/30/2024       Contributor(s): William Sharp, Teresa (T.) Burrell, Rashelle Berry
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