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Enhanced Delivery and Efficacy of Antisense Drugs via Covalently Linked Nanodisc Scaffolds
Application A synthetic nanodisc (ND) scaffold for delivering antisense oligonucleotides (ASOs) for the treatment of disease. Key Benefits Improved cellular uptake and protein suppression using antisense oligos. Longer ASO half-life compared to other ASO delivery methods. Potential to overcome the delivery and efficacy challenges using ASOs for...
Published: 7/22/2024       Contributor(s): Khalid Salaita, Radhika Sharma
A Method of Using Responsive Micro and Sub-micro Scale Polymer Particles for Mechanical Manipulation of Molecules
Application A method to study the mechanical/controlled unfolding of biomolecules using a polymer force clamp (PFC). Key Benefits Particles can be immobilized onto virtually any type of support. Particles can also be functionalized with a variety of small-molecule, peptide and protein ligands. Ability to have multiple PFC’s measuring associated...
Published: 4/23/2024       Contributor(s): Hanquan Su, Khalid Salaita