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Combinatorial Therapy for Preserving Muscle Mass During Weight Loss
Application
A combinatorial therapy to preserve muscle mass during semaglutide weight loss treatment.
Key Benefits
Preserves lean mass during semaglutide treatment in preclinical mouse models.
Increases overall fat loss without affecting food/water intake during semaglutide treatment in preclinical mouse models.
Market Summary
The prevalence...
Published: 12/5/2025
Contributor(s): Todd Golde, Yong Ran, Eric Krause, Annette De Kloet, Karen Scott
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Novel Inhibitors of NOX2/ROS
Applications
Novel therapeutics for treatment of various inflammatory airway conditions including chronic obstructive pulmonary disease (COPD).
Key Benefits
NOX2/ROS inhibitors have potential for use in a wide variety of clinical indications.
Current treatments are weakly effective or provide only symptomatic relief for inflammatory airway diseases.
Technical...
Published: 2/13/2025
Contributor(s): Thota Ganesh, John David Lambeth, Susan Smith, Aiming Sun
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Functional Restoration of Diabetic Bone Marrow-Derived Cells
Application
Methods for restoration of diabetic bone marrow cell function for cell based therapy, using pre-existing molecules and their derivatives.
Key Benefits
Ability to "reactivate" diabetic bone marrow-derived stem or progenitor cells which also include peripheral blood cells such as endothelial progenitor cells.
Cells are more...
Published: 5/30/2025
Contributor(s): Young-Sup Yoon, Ji Woong (Jay) Han
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Growth Factor as a Treatment for Obesity
Applications
Therapeutic use of Glial Cell Line-Derived Neurotrophic Factor (GDNF) to treat obesity.
Potential drug target for further therapeutic development.
Key Benefits
Growth Factor expression in the brain causes a reduction in high fat diet-induced obesity.
Fat level reduction has been shown in both mouse and human cells.
Reducing...
Published: 11/5/2025
Contributor(s): Shanthi Srinivasan
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Neurotrophic Factor as Therapeutic for Diabetes
Application
The use of Glial Cell-derived Neurotrophic Factor (GDNF) or its mimics as a potential therapeutic for diabetes mellitus type 1 (IDDM).
Key Benefits
GDNF enhances pancreatic β-cell growth and survival in vitro and in vivo.
GDNF transgenic mice have lower blood glucose levels and are more resistant to developing diabetes compared...
Published: 7/22/2025
Contributor(s): Shanthi Srinivasan
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