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HDAC Inhibitors for Managing Vascular Conditions and Diabetic Peripheral Neuropathies
Application Treatment of diabetic neuropathy using epigenetic modulators, histone deacetylase inhibitors (HDACis), to ameliorate or prevent vascular conditions and neuropathic pains by nerve damages. Key Benefits Reverses or protects against diabetes-induced nerve damages by direct injection of HDACi. Relatively low regulatory risk because many...
Published: 2/13/2025       Contributor(s): Young-Sup Yoon, Ji Woong (Jay) Han, Hyunsuk Shim
Novel Inhibitors of NOX2/ROS
Applications Novel therapeutics for treatment of various inflammatory airway conditions including chronic obstructive pulmonary disease (COPD). Key Benefits NOX2/ROS inhibitors have potential for use in a wide variety of clinical indications. Current treatments are weakly effective or provide only symptomatic relief for inflammatory airway diseases. Technical...
Published: 2/13/2025       Contributor(s): Thota Ganesh, John David Lambeth, Susan Smith, Aiming Sun
Functional Restoration of Diabetic Bone Marrow-Derived Cells
Application Methods for restoration of diabetic bone marrow cell function for cell based therapy, using pre-existing molecules and their derivatives. Key Benefits Ability to "reactivate" diabetic bone marrow-derived stem or progenitor cells which also include peripheral blood cells such as endothelial progenitor cells. Cells are more...
Published: 2/13/2025       Contributor(s): Young-Sup Yoon, Ji Woong (Jay) Han