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Next Gen Immune-Optimized Gene Delivery
Application
An advanced gene therapy approach that improves therapeutic efficiency by protecting transgene expressing cells from host immune responses, through modulation of a key immune checkpoint pathway.
Key Benefits
Enhanced efficiency across viral and non-viral gene delivery systems, including AAV, lentivirus, LNPs, and electroporation.
Enables...
Published: 2/23/2026
Contributor(s): Matthew (Matt) Gardner, Michael Kuipa, Abubakarr Koroma, Isai Leguizamo
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Cell Line for Generating Nonhuman Primate T Cells
Application
Cell line for efficient in vitro differentiation of rhesus macaque-specific T cells from hematopoietic stem and progenitor cells.
Key Benefits
Replaces need for primary rhesus macaque thymus tissue.
Improves differentiation efficiency and reduces media requirements compared to existing methods.
Yields CD4+ and CD8+ T cells, double-positive...
Published: 1/20/2026
Contributor(s): Sheikh Rahman
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Molecules Targeting Inflammatory Signaling
Application
A group of small molecules for treating central and peripheral diseases associated with inflammation.
Key Benefits
Applicable to a wide variety of central nervous system and peripheral diseases.
Can bypass side effects of existing therapeutics targeting similar inflammatory pathways.
High target selectivity and aqueous solubility.
Capability...
Published: 2/24/2026
Contributor(s): Raymond (Ray) Dingledine, Radhika Amaradhi, Shabber Mohammed, Thota Ganesh
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MVA and DNA Based SARS-CoV-2 Vaccines
Application
Modified Vaccinia virus Ankara (MVA)- and deoxyribonucleic acid (DNA)-based vaccine for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Key Benefits
Safety profile is known.
Demonstrated antiviral activity against related Coronaviruses.
Single dose of vaccination was shown to be effective against related Coronaviruses...
Published: 1/20/2026
Contributor(s): Rama Rao Amara, Sailaja Gangadhara
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Vaccine-pulsed Dendritic Cells as a Treatment for Aggressive Breast Cancers
Application
Immunotherapy for HER2+ and triple-negative breast cancer.
Key Benefits
Autologous vaccine comprising patient-specific tumor antigens and immune stimulatory components against aggressive breast cancers.
Prepared outside of the body and then administered to patients.
Preclinical data indicate treatment decreases tumor growth and improves...
Published: 1/20/2026
Contributor(s): Periasamy (Selva) Selvaraj, Luis Munoz, Ramireddy Bommireddy, Christopher Pack, Shaker Reddy, Sampath Ramachandiran
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Vital Sign Trajectory Algorithm
Application
A precision medicine algorithm that reduces mortality in sepsis patients by individualizing and targeting specific therapies to specific patients.
Key Benefits
An algorithm that uses bedside routine vital signs to optimize the precision treatment of sepsis.
Clinical data show the ability of the algorithm to identify a subset of patients...
Published: 2/13/2025
Contributor(s): Sivasubramanium (Siva) Bhavani
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Improving Pediatric Asthma Management for Urban Families
Application
Home-based family psychoeducational intervention for low-income children with persistent asthma.
Key Benefits
Medical and psychosocial needs of patients and family members can be addressed simultaneously.
Significantly improved asthma management and caregiver stress in randomized controlled clinical trial.
Market Summary
Asthma...
Published: 2/13/2025
Contributor(s): Marianne Celano, Lisa Kobrynski, Chanda Holsey
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Methods for Enhancing MSC Therapeutic Potential for Treatment of Osteoarthritis by Measuring and Targeting Intracellular Pathways
Application
Highly transformative new strategy to enhance mesenchymal stromal cell consistency and efficacy for taking MSC therapies to clinical stage.
Key Benefits
Currently there is no method to determine if an MSC donor line will be therapeutically effective.
Provides a point of use assay in the clinical setting which can determine MSC efficacy...
Published: 2/5/2026
Contributor(s): Nick Willett, Levi Wood, Jay McKinney
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Novel Piperidine-Amide Derivatives as CXCR4 Modulators
Application
A new class of CXCR4 modulators for metastasis and inflammation.
Key Benefits
Selective for only one allosteric site on CXCR4.
Lower adverse effects.
Market Summary
Activation of the CXCR4 receptor triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone...
Published: 10/15/2025
Contributor(s): Hyunsuk Shim, Yoon Hyeun Oum
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Targeted Immunotherapy for KRAS-Driven Cancers
Application
Targeted immunotherapy and companion biosensing approach for cancers harboring the KRASG12V mutation.
Key Benefits
First-in-class therapeutic strategy specifically designed for KRASG12V-positive cancers.
Addresses a significant unmet need in oncology where no approved KRASG12V-targeted therapies currently exist.
Restores the body’s...
Published: 2/23/2026
Contributor(s): Haian Fu, Cong Tang, Xiulei Mo
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