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Small Molecule Inhibitors of the p38/MK2 Protein Interaction
Application
New class of small molecule inhibitors with therapeutic potential for inflammatory diseases through disruption of the p38/MK2 protein-protein interaction.
Key Benefits
Therapeutic potential and utility for various inflammatory diseases.
May have potentially fewer off-target effects and dose-limiting toxicities.
May serve as a foundation...
Published: 7/10/2026
Contributor(s): Andrey Ivanov, Haian Fu
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New Treatment for Pain
Application
Veragranine A analogs with improved synthetic efficiency and enhanced potency for the treatment of pain.
Key Benefits
Increased synthetic efficiency of Veragranine A analogs, helping address supply limitations.
Synthetic analogs demonstrate greater potency than Veragranine A and may offer improved pharmacological response.
The analogs...
Published: 7/9/2026
Contributor(s): Mingji Dai, Donghui Ma, Reem Al-Ahmad, Rajesh Khanna
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Predictive Model for Post Surgery Prostate Cancer Recurrence
Application
An artificial intelligence based prognostic model for early Biochemical recurrence (BCR) risk assessment of men post-radical prostatectomy.
Key Benefits
Identifies significant features, including tumor-infiltrating lymphocytes (TIL), in prostate cancer recurrence.
Market Summary
Prostate cancer is one of the most diagnosed cancers...
Published: 3/2/2026
Contributor(s): Sebastian Medina, Kamal Hammouda, Tilak Pathak, Anant Madabhushi, Tuomas Mirtti
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Next Gen Immune-Optimized Gene Delivery
Application
An advanced gene therapy approach that improves therapeutic efficiency by protecting transgene expressing cells from host immune responses, through modulation of a key immune checkpoint pathway.
Key Benefits
Enhanced efficiency across viral and non-viral gene delivery systems, including AAV, lentivirus, LNPs, and electroporation.
Enables...
Published: 6/15/2026
Contributor(s): Matthew (Matt) Gardner, Michael Kuipa, Abubakarr Koroma, Isai Leguizamo
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Cell Line for Generating Nonhuman Primate T Cells
Application
Cell line for efficient in vitro differentiation of rhesus macaque-specific T cells from hematopoietic stem and progenitor cells.
Key Benefits
Replaces need for primary rhesus macaque thymus tissue.
Improves differentiation efficiency and reduces media requirements compared to existing methods.
Yields CD4+ and CD8+ T cells, double-positive...
Published: 1/20/2026
Contributor(s): Sheikh Rahman
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Molecules Targeting Inflammatory Signaling
Application
A group of small molecules for treating central and peripheral diseases associated with inflammation.
Key Benefits
Applicable to a wide variety of central nervous system and peripheral diseases.
Can bypass side effects of existing therapeutics targeting similar inflammatory pathways.
High target selectivity and aqueous solubility.
Capability...
Published: 5/22/2026
Contributor(s): Raymond (Ray) Dingledine, Radhika Amaradhi, Shabber Mohammed, Thota Ganesh
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MVA and DNA Based SARS-CoV-2 Vaccines
Application
Modified Vaccinia virus Ankara (MVA)- and deoxyribonucleic acid (DNA)-based vaccine for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Key Benefits
Safety profile is known.
Demonstrated antiviral activity against related Coronaviruses.
Single dose of vaccination was shown to be effective against related Coronaviruses...
Published: 5/22/2026
Contributor(s): Rama Rao Amara, Sailaja Gangadhara
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Vaccine-pulsed Dendritic Cells as a Treatment for Aggressive Breast Cancers
Application
Immunotherapy for HER2+ and triple-negative breast cancer.
Key Benefits
Autologous vaccine comprising patient-specific tumor antigens and immune stimulatory components against aggressive breast cancers.
Prepared outside of the body and then administered to patients.
Preclinical data indicate treatment decreases tumor growth and improves...
Published: 6/22/2026
Contributor(s): Periasamy (Selva) Selvaraj, Luis Munoz, Ramireddy Bommireddy, Christopher Pack, Shaker Reddy, Sampath Ramachandiran
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Vital Sign Trajectory Algorithm
Application
A precision medicine algorithm that reduces mortality in sepsis patients by individualizing and targeting specific therapies to specific patients.
Key Benefits
An algorithm that uses bedside routine vital signs to optimize the precision treatment of sepsis.
Clinical data show the ability of the algorithm to identify a subset of patients...
Published: 2/13/2025
Contributor(s): Sivasubramanium (Siva) Bhavani
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Improving Pediatric Asthma Management for Urban Families
Application
Home-based family psychoeducational intervention for low-income children with persistent asthma.
Key Benefits
Medical and psychosocial needs of patients and family members can be addressed simultaneously.
Significantly improved asthma management and caregiver stress in randomized controlled clinical trial.
Market Summary
Asthma...
Published: 2/13/2025
Contributor(s): Marianne Celano, Lisa Kobrynski, Chanda Holsey
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