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Total Ankle Arthroplasty Design
Application
An intra-articular alignment guide for ankle replacement system to treat ankle arthritis.
Key Benefits
Less invasive method that does not require drilling a hole through the heel for Inbone II tibial stem placement.
More convenient to use compared to Inbone II frame and foot holder to find the correct alignment.
Market Summary
Approximately...
Published: 7/30/2024
Contributor(s): Rishin Kadakia
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Therapeutic Target for Hepatic Fibrosis
ApplicationPeriostin as a therapeutic target for liver disease.Key BenefitsNew therapeutic target for preventing fibrosis from entering cirrhosis stage.Therapeutic target may be used for identifying new therapy for fibrosis.Market SummaryCirrhosis is a condition in which the liver is unable to function normally due to chronic, or long lasting, injury....
Published: 11/20/2024
Contributor(s): Frank Anania, Pradeep Kumar
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CIITA Deficient Human B Cell Line
Application
Human B cell line deficient in class II transactivator (CIITA).
Key Benefits
Deficient in CIITA.
Useful for expression of tranfected MHC-II genes and alleles.
Technical Summary
The class II transactivator (CIITA) is essential for the expression of major histocompatibility complex class II (MHC-II) genes. However, the role of CIITA...
Published: 9/26/2024
Contributor(s): Jeremy Boss, Christopher (Chris) Scharer
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Recombinant Respiratory Syncytial Virus (RSV) Firefly Luciferase Reporter Strain
Application
Modified recombinant syncytial virus (RSV) strain expressing a bioluminescent reporter protein for high throughput screening and vaccine development.
Key Benefits
Provides a new high throughput screening tool for RSV vaccine development and drug discovery.
Firefly luciferase based assays show better signal-to-noise than fluorescence-based...
Published: 9/26/2024
Contributor(s): Richard Plemper, Martin Moore
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Recombinant RSV Strains Expressing Renilla Luciferase and G & F Proteins
Application
Recombinant respiratory syncytial virus (RSV) strains expressing the G and F Proteins from RSV strains as well as renilla luciferase for use in drug and vaccine screening.
Key Benefits
Provides new and needed tool for screening potential RSV therapies, ensuring they are broadly effective against multiple, distinct strains of the virus....
Published: 9/26/2024
Contributor(s): Martin Moore, Jia Meng
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Respiratory Syncytial Virus (RSV) A/2001/2-20 Strain with Enhanced Pathogenesis
Applications
Strain of respiratory syncytial virus (RSV) for use in drug and vaccine development.
Key Benefits
Exhibits increased mucin expression and early epithelial damage in mouse models.
Provides a platform for animal models focused on early airway histopathology.
Market Summary
RSV is the most common cause of severe respiratory illness...
Published: 9/26/2024
Contributor(s): Martin Moore
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Brominated Noscapine as a Potent Anti-Inflammatory
Key Benefits
Noscapine has been used safely in humans for over 30 years.
Noscapine analogs can inhibit inflammation in in vitro models.
Technical Summary
The innate immune system plays a crucial role in host defense and homeostasis. Innate immune responses are induced when pattern recognition receptors such as Toll-like receptors (TLR) sense...
Published: 11/20/2024
Contributor(s): Susu Zughaier, Ritu Aneja, David Stephens
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Triptolide Analog as Potent Anti-Inflammatory Drug Candidate
Application
Small molecule therapeutics for the treatment of inflammation and autoimmune disorders.
Key Benefits
Decreased toxicity compared to the natural product triptolide.
Improved aqueous solubility compared to triptolide.
Market Summary
Inflammation is known to be a component in a wide range of disease states including arthritis, asthma,...
Published: 9/26/2024
Contributor(s): Hariharan Venkatesan, James Snyder, Dennis Liotta, Susheng Wang
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