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Novel Piperidine-Amide Derivatives as CXCR4 Modulators
­ Application A new class of CXCR4 modulators for metastasis and inflammation. Key Benefits Selective for only one allosteric site on CXCR4. Lower adverse effects. Market Summary Multiple myeloma, acute myeloid leukemia, HIV, and rheumatoid arthritis all involve the G-protein receptor CXCR4. Currently, there is only one FDA approved CXCR4...
Published: 5/17/2022       Contributor(s): Hyunsuk Shim, Yoon Oum
HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform
­ Application High Throughput Screening for identifying effective immuno-modulators. Key Benefits HT screening platform replicating complex immune medicated response to facilitate discovery of small molecule immunomodulatory agents. Simplicity and dual readouts of the design enable the screening of large chemical libraries to identify compounds...
Published: 5/17/2022       Contributor(s): Xiulei Mo, Haian Fu
Adenosine Gel to Treat Inflammation
­ Application Hydrogel to treat inflammation after cardiac injury, pericarditis, myocardial infarction, and myocarditis. Key Benefits Minimally invasive. Increases levels of adenosine in target tissues. Can be applied to other organs such as liver and kidneys. Could be used to promote hair and nail growth. Market Summary Neutrophil extracellular...
Published: 5/13/2022       Contributor(s): Rebecca Levit, Andres Garcia
KRAS Mutant Protein-Protein Interaction Targets and Inhibitors for Cancer Therapy
­ Application Immunotherapeutic agent and biosensor for KRASG12V mutation in tumor cells. Key Benefits First in class, targeted immunotherapy for patients presented with KRASG12V mutation. Attenuates immune suppression associated with KRASG12V-positive cancers. Market Summary The KRASG12V mutation, representing 85% of all cancer mutations,...
Published: 1/7/2022       Contributor(s): Haian Fu, Cong Tang, Xiulei Mo
Interleukin-37 to Enhance Effectiveness of CAR T-cell Therapy
­ Application IL-37-expressing CAR T-cells to treat B-cell acute lymphoblastic leukemia. Key Benefits Boosts the function of aged T-cells. Enhances the effectiveness of CAR T-cell therapy. Therapeutic potential to overcome aging-associated immune-senescence. Potent suppressor of chronic inflammation or pro-inflammatory cytokines. Market...
Published: 1/6/2022       Contributor(s): Curtis Henry, Sunil Raikar, Sarwish Rafiq
HIV-1 Clade C Protein Immunogen as HIV-1 Vaccine
Application Novel stabilized HIV-1 Clade C gp140 trimeric immunogen useful as a vaccine. Key Benefits Vaccine for HIV-1 infections. Induces both neutralizing and V1V2 scaffold directed antibody responses. V1V2 scaffold directed antibodies bind to multiple strains of HIV-1 from different clades including Clades B and C. Market Summary HIV-1...
Published: 11/20/2020       Contributor(s): Rama Amara, Sailaja Gangadhara, Tiffany Styles, Anusmita Sahoo
Photocaged Cytokines for Cancer Immunotherapy
Application Light-responsive cytokine prodrugs with controlled activation for improved cancer immunotherapy. Key Benefits Spatiotemporal control of therapeutic cytokine activation leads to controlled local activation and reduces off-target toxicity. Prolonged circulation means less frequent dosing is required. Biased activity towards CD8+ T-cells...
Published: 11/2/2020       Contributor(s): Erik Dreaden, Lacey Perdue, Priscilla Do
PNP-based Solid Tumor Therapy in Conjunction with Checkpoint Blockade Inhibitors
Application Treatment of solid tumors combining purine nucleoside phosphorylase (PNP) technology with checkpoint blockade inhibition. Key Benefits Safe and effective method for markedly enhancing checkpoint blockade therapy for refractory tumors. Checkpoint inhibitor therapy is FDA-approved and already in use. Market Summary Checkpoint blockade...
Published: 10/22/2020       Contributor(s): Eric Sorscher, Turang Behbahani, Regina Rab, Annette Ehrhardt, Jeong Hong, Disha Joshi
Boosting Immunogenicity of Vaccines Using Saponins and Agonists of the Intracellular STING Pathway
Application Vaccine formulation of an activator of the stimulator of interferon genes (STING) pathway and saponin adjuvant for enhanced protection of aged population. Key Benefits Significantly improved protective immunity of vaccine in the aged. More efficient than the current methods of influenza vaccination of population 65 years of age or...
Published: 4/24/2020       Contributor(s): Elena Vassilieva, Richard Compans
Glycoprotein Tetramer for Identifying Antigen-specific B Cells
ApplicationEctodomain of viral glycoprotein tetramers detects antigen-specific memory B Cells.Key BenefitsViral glycoprotein tetramers detect antigen-specific memory B cells in the peripheral blood and tissues.Hepatitis C virus E2 protein triggers immune response, which may yield an effective vaccine against hepatitis C virus.Market SummaryHepatitis...
Published: 5/9/2019       Contributor(s): Arash Grakoui, Joseph Marcotrigiano
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