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Additives that Increase Storage and Shelf Life of Platelets

Application Monoclonal antibody additive that inhibits ectodomain shedding of a platelet glycoprotein to improve platelet storage. Key Benefits Current storage techniques allows for limited storage times (5-7 days). New additive may enable platelet storage at 4°C, increase platelet storage time, and improve quality of stored platelets. Inhibits...

Published: 11/2/2020 Contributor(s): Renhao Li

Hemophilia-Related Distress Questionnaire

Application Instrument to quantitatively measure distress associated with hemophilia and its management. Key Benefits Concise, easy to score, and multi-factorial test. Consistent test-retest reliability. Promotes improved patient health outcomes. Market Summary In the US, approximately 400 babies per year are born with hemophilia and there...

Published: 10/19/2020 Contributor(s): Christine Kempton, Vaughn Barry, Shanna Mattis, Mary Lynch (O'Neill)

Micron-Sized Drug Vehicle for Unregulated Blood Clotting

Application Fibrinogen-coated micron-sized drug vehicles for targeted treatment of unregulated blood clotting. Key Benefits Facilitates targeted release of drugs specifically for blood clotting disorders. Drug delivery vehicle can be used with newly discovered or known therapeutics on the market. Site specific biological mechanism may help increase...

Published: 2/20/2017 Contributor(s): Caroline Hansen, Yumiko Sakurai, Wilbur Lam, Andrew Lyon

High Throughput Individual Platelet Nanomechanical Contraction Device

Application A microfluidic device for the measurement and quantification of the mechanical forces that occur during clot formation for use in hematology research or for diagnostic purposes. Key Benefits Is capable of measuring platelet-platelet interactions at the single cell level that is not possible with current tools. Facilitates quick & easy...

Published: 4/29/2014 Contributor(s): David Myers, Wilbur Lam, Yongzhi Qiu

Algorithm and Software Application for the Diagnosis of Adverse Reactions to Blood Transfusion

Application Web-based and mobile application based on the National Healthcare Safety Network’s Biovigilance Component Hemovigilance Module Surveillance Protocol to aid in the identification of adverse reactions to transfusions easily and accurately. Key Benefits Provides a quick, easy, and accurate method to identify transfusion reactions according...

Published: 4/11/2014 Contributor(s): John Roback, Geoffrey Smith

Repurposed Antifibrinolytic Agents as a Substitute for Platelet Transfusions to Prevent Bleeding in Severe Thrombocytopenia Patients

Application Prophylactic administration of an antifibrinolytic agent, epsilon aminocaproic acid (EACA), to prevent bleeding in patients with thrombocytopenia from hematological malignancies. Key Benefits Orally bioavailable, repurposed drug. Commonly used and FDA approved to manage hemorrhage in patients with congenital bleeding. Cheaper and easier...

Published: 4/9/2014 Contributor(s): Hanna Khoury, Ana Antun

P-selectin Inhibitor for the Treatment of Sickle Cell Disease

Application A glycopeptide inhibitor of p-selectin for the treatment of sickle cell disease. Key Benefits Blocks the activity of P-selectin with nM affinity. Potential treatment for vaso-occlusive crisis associated with sickle cell disease. Inhibits the earliest stage of leukocyte activation helping to prevent immune response. Market Summary Sickle...

Published: 12/4/2013 Contributor(s): Richard Cummings, Elliot Chaikof, Venkata Krishnamurthy, Mohammed Sardar

Newborn Pulse Oximetry Data Interpretation Software and Mobile App

Application Web software and mobile app for interpreting and qualifying newborn pulse oximetry data. Key Benefits Reduces interpretation of pulse oximetry data. Provides decision support type feedback. Based upon algorithm endorsed by the American Academy of Pediatrics and the American Heart Association. Market Summary In the past 10 years, the...

Published: 1/8/2013 Contributor(s): Matthew Oster

Evaluation of Red Blood Cells (RBC) to Predict Post-Transfusion Survival

ApplicationTechnique to evaluate red blood cell units (RBC) and predict their post-transfusion survival.Key BenefitsNo existing techniques to predict post-transfusion survival of RBC units. Provides a quality control technique to predict post-transfusion survival of RBC units prior to transfusion. Market SummaryOver 15 million units of red blood cells...

Published: 3/27/2012 Contributor(s): James Zimring, John Roback, Larry Dumont