HDAC Inhibitors for Managing Vascular Conditions and Diabetic Peripheral Neuropathies
Treatment of diabetic neuropathy using epigenetic modulators, histone deacetylase inhibitors (HDACis), to ameliorate or prevent vascular conditions and neuropathic pains by nerve damages.
Reverses or protects against diabetes-induced nerve damages by direct injection of HDACi.
Relatively low regulatory risk because many...
Inventor(s): Young-Sup Yoon, Ji Woong Han, Hyunsuk Shim
Liver Receptor Homolog 1 (LRH-1) Agonist for the Treatment of Type 2 Diabetes and Inflammatory Bowel Disease
ApplicationSmall molecule agonist that changes the expression of LRH-1 genes involved with lipid metabolism and inflammation.Key BenefitsLess toxic and more potent molecule compared to known LRH-1 agonists.More soluble compound that improves its pharmacokinetics (PK).Market SummaryLiver receptor homolog 1 (LRH-1) is a nuclear hormone receptor that is...
Inventor(s): Eric Ortlund, Suzanne Mays, Nathan Jui, Autumn Flynn, Michael Dugan
Guide to Goals (G2G): Application for Type 1 Diabetes Management in Children
ApplicationWeb-based application for both self and clinical assessment and management of pediatric type 1 diabetes population.Key BenefitsSpecific for pediatric type 1 diabetes population.Patient involvement at point-of-care encourages patient-directed, goal-driven therapy.Provides simple, user friendly interface based on American Diabetes Association...
Inventor(s): Andrew Muir, Prabhu Shankar, Michael Owens, Leanne West, Gregory Bishop, Yevgeniy Agalov
Latino Diabetes Education Program
ApplicationComputer-based diabetes education program in Spanish for the Latino population.Key BenefitsCulturally appropriate program in Spanish and English. Program offers supplemental materials including DVD, website, and nutrition information. Program offers free monthly classes. Market SummaryDiabetes affects nearly 275 million people worldwide and...
Inventor(s): Britt Rotberg Wolfe, Guillermo Umpierrez