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Precision Protein Repair Platform for Missense Mutations
Application
This technology enables targeted chemical correction of missense mutations in proteins using a modular heterotrifunctional molecule platform.
Key Benefits
Restores protein function by chemically mimicking healthy amino acid side chains.
Modular toolkit allows rapid customization for diverse protein targets.
Validated across multiple...
Published: 11/12/2025
Contributor(s): Monika Raj
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Gene Editing for Head and Neck Cancer Treatment
Application
Method for delivering gene-editing therapeutic in head and neck cancers.
Key Benefits
CRISPR/CAS9-based gene editing mechanism targeting novel disease-modifying gene.
Liquid nanoparticle encapsulation permitting in vivo delivery.
Market Summary
Head and neck cancers (HNC) are the 7th most common global cancer, accounting for 3%...
Published: 11/7/2025
Contributor(s): Yong Teng, Yamin Li
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Anticancer Agent with N-Glycan Specificity
Application
An engineered protein for targeting disease-associated N-glycans.
Key Benefits
High affinity, pH insensitive, no cofactors required.
Applications in anticancer and antiviral therapeutics and research.
Can aid in manufacturing monoclonal antibodies with desired N-glycosylation properties.
Market Summary
Glycosylation involves post-translation...
Published: 11/3/2025
Contributor(s): Eric J. Sundberg, Diego Sastre, Maros Huliciak
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Treatment for Dengue Virus (DENV) Infection
Application
Antiviral therapeutic for multiple Dengue virus serotypes.
Key Benefits
Targets conserved regions of DENV genomes, enabling efficacy across serotypes.
Mitigates lethal infections with a single lipid nanoparticle (LNP) based dose in mice.
Minimal off-target effects.
Market Summary
Despite 390+ million annual DENV infections, there...
Published: 10/30/2025
Contributor(s): Philip Santangelo, Daryll Vanover, Chiara Zurla, Lorena Carvalho de Souza Chaves
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Combinatorial Therapy for Preserving Muscle Mass During Weight Loss
Application
A combinatorial therapy to preserve muscle mass during semaglutide weight loss treatment.
Key Benefits
Preserves lean mass during semaglutide treatment in preclinical mouse models.
Increases overall fat loss without affecting food/water intake during semaglutide treatment in preclinical mouse models.
Market Summary
The prevalence...
Published: 11/13/2025
Contributor(s): Todd Golde, Yong Ran, Eric Krause, Annette De Kloet, Karen Scott
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MKK3/MYC Protein-Protein Interaction Inhibitor Overcomes Resistant Non-Small Cell Lung Cancer
Application
A therapeutic use for SGI-1027 in the treatment of Osimertinib-resistant non-small cell lung cancer (NSCLC).
Key Benefits
The MKK3/MYC protein-protein interaction inhibitor SGI-1027 effectively decreases MYC levels in Osimertinib-resistant NSCLC cell lines.
The combination of SGI-1027 with Osimertinib offers synergistic benefits over...
Published: 10/15/2025
Contributor(s): Andrey Ivanov, Haian Fu, Shi-Yong Sun, Zhen Chen
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