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Optimizing the Engineering of CAR-T Cells
Application
A method for selecting distinct T cell populations in order to generate more effective CAR-T cells.
Key Benefits
The proposed invention focuses on selecting the optimal “starting material” for the engineering CAR-T cells.
This selection method can be utilized for the development of any and all CAR-T therapies, not limited...
Published: 2/13/2025
Contributor(s): Byron Au-Yeung
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Advancing Lymphatic Endothelial Cell Generation from iPSCs
Application
The developed protocol offers a reproducible and scalable method for generating lymphatic endothelial cells (LECs) from induced pluripotent stem cells (iPSCs), addressing critical challenges in the field of lymphatic-related therapies.
Key Benefits
Reproducible and scalable protocol for generating LECs from iPSCs.
Utilizes specific...
Published: 2/13/2025
Contributor(s): Katherine Hekman, Katherine Owsiany
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Guiding the Cartilage Repair Microenvironment
Application
A novel method to improve the effectiveness of marrow-mediated cartilage repair.
Key Benefits
Enhances the efficacy of the marrow stimulation procedure for cartilage repair.
Priming the cartilage repair environment to enable subsequent healthy tissue growth.
Potential to become a one-step, implementable, and effective treatment for...
Published: 2/13/2025
Contributor(s): Sameh Labib, David Myers, Jay M. Patel, Maddie Hasson, Lorenzo Fernandes
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Improving CAR T cell efficacy with Cytokine-Loaded Microparticles
Application
Novel reagents for manufacturing of CAR T cells with improved characteristics.
Key Benefits
A multi-cytokine backpack particle that can be used during manufacturing process of CAR T treatments to improve their phenotype and efficacy.
Preliminary data show the method can transduce primary healthy and patient T cells and promote CAR...
Published: 2/13/2025
Contributor(s): Sarwish Rafiq, Erik Dreaden, A K M Nawshad Hossian, Biaggio Uricoli
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Methods for Enhancing MSC Therapeutic Potential for Treatment of Osteoarthritis by Measuring and Targeting Intracellular Pathways
Application
Highly transformative new strategy to enhance mesenchymal stromal cell consistency and efficacy for taking MSC therapies to clinical stage.
Key Benefits
Currently there is no method to determine if an MSC donor line will be therapeutically effective.
Provides a point of use assay in the clinical setting which can determine MSC efficacy...
Published: 2/13/2025
Contributor(s): Nick Willett, Levi Wood, Jay McKinney
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Tumor Specific CD8 T Cell TCR Sequences of HPV-Positive Head and Neck Tumors
Application
HPV-specific CD8 TCR sequences for the treatment of HPV-positive head and neck cancer by adoptive cell therapy.
Key Benefits
HPV tumor antigen set is specific for HPV-positive head and neck cancer.
Targeting of ‘non-classical’ HPV antigens E2 and E5.
Potential to synergize and complement HPV E6/7-specific TCR therapies...
Published: 2/13/2025
Contributor(s): Rafi Ahmed, Christiane Eberhardt, Andreas Wieland
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Isolation of Therapeutic cells and Framework for Adoptive Cell Therapies
Application
Isolation of therapeutic cells and framework for adoptive cell therapies based around stem-like chronic memory CD8 T cells that may be paired with PD-1 blockade.
Key Benefits
Persistent cell survival and therapeutic efficacy following rechallenge with chronic viral infection and cancer.
Strong co-treatment potential with PD-1...
Published: 2/13/2025
Contributor(s): Rafi Ahmed, Daniel Chang
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Interleukin-37 to Enhance Effectiveness of CAR T-cell Therapy
Application
IL-37-expressing CAR T-cells to treat B-cell acute lymphoblastic leukemia.
Key Benefits
Boosts the function of aged T-cells.
Enhances the effectiveness of CAR T-cell therapy.
Therapeutic potential to overcome aging-associated immune-senescence.
Potent suppressor of chronic inflammation or pro-inflammatory cytokines.
Market...
Published: 2/13/2025
Contributor(s): Curtis Henry, Sunil Raikar, Sarwish Rafiq
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High-Throughput Platform for Imaging and Maintaining Cells in Culture
Application
This closed-loop platform monitors and maintains traditional cell culture and bioengineered tissues to automate standard and custom cell maintenance protocols, including stem cell differentiations, bioengineered tissue generation, and functional maturation of complex cell cultures.
Key Benefits
Automation of cell culture maintenance
Integration...
Published: 2/13/2025
Contributor(s): Vahid Serpooshan, Ayda Melika, Amir Pourmorteza
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PNP-based Solid Tumor Therapy in Conjunction with Checkpoint Blockade Inhibitors
Application
Treatment of solid tumors combining purine nucleoside phosphorylase (PNP) technology with checkpoint blockade inhibition.
Key Benefits
Safe and effective method for markedly enhancing checkpoint blockade therapy for refractory tumors.
Checkpoint inhibitor therapy is FDA-approved and already in use.
Market Summary
Checkpoint blockade...
Published: 2/13/2025
Contributor(s): Eric J. Sorscher, Turang Behbahani, Regina Rab, Annette Ehrhardt, Jeong Hong, Disha Joshi
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