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Repurposing a Potent MDM2 Inhibitor for Leukemia Treatment
Application
VERU-111, also known as sabizabulin, is a potent microtubule inhibitor and, notably, an MDM2 inhibitor. This repurposed compound demonstrates remarkable efficacy in the treatment of Acute Myeloid Leukemia (AML).
Key Benefits
Unique dual-action functionality as a microtubule and MDM2 inhibitor.
Successful inhibition of MDM2, an oncogene...
Published: 8/22/2024
Contributor(s): Deborah DeRyckere, Muxiang Zhou, Lu Bing Gu, Douglas Graham, Tao Liu
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Caspase-3 Deficient MEFs with Mutant Caspase-3 Re-Introduced
Application
Mouse embryonic fibroblast (MEF) line deficient in caspase-3 that are reconstituted with constitutively expressed mutant versions of the protease.
Key Benefits
An immortalized caspase-3-deficient MEF cell line.
Tool to study protease induced apoptosis.
Technical Summary
Emory inventors have discriminated a previously unknown role...
Published: 9/26/2024
Contributor(s): Lawrence Boise, Katelyn Ponder
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HIF/Hypoxia-Reporter Cell Lines
Application
Hypoxia/Hypoxia-inducible factor 1 (HIF-1) inducible luciferase/LacZ reporter cell lines.
Key Benefit
Expression of luciferase and beta-galactosidase in response to hypoxia treatment.
Technical Summary
Emory University researcher, Erwin Van Meir, has made HIF/hypoxia reporter cell lines by stably transfecting the cells with pBIGL-V6R-HRE-Luc/LacZ...
Published: 9/26/2024
Contributor(s): Erwin Van Meir
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ADGRB3/BAI3-Expressing Cell Lines
ApplicationADGRB3/BAI3 expressing human brain tumor cell lines.Technical SummaryAdhesion G protein coupled receptor B3 (ADGRB3), also called Brain-specific angiogenesis inhibitor 3 (BAI3) is a protein that in humans is encoded by the ADGRB3 gene. Emory University researcher Erwin Van Meir has developed medulloblastoma cell lines DAOY, UW288-1 and PFSK1,...
Published: 9/26/2024
Contributor(s): Erwin Van Meir
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Human Induced Pluripotent Stem Cells
ApplicationHuman induced pluripotent stem cells useful for human stem cell biology, Lesch-Nyhan disease or DYT1 dystonia.Technical SummaryLesch-Nyhan syndrome (juvenile gout) is a rare, inherited disorder caused by deficiency in hypoxanthine-guanine phosphoribosyltransferase (HGPRT). The disease causes overproduction of uric acid often leading to gout...
Published: 9/26/2024
Contributor(s): Hyder Jinnah
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CIITA Deficient Human B Cell Line
Application
Human B cell line deficient in class II transactivator (CIITA).
Key Benefits
Deficient in CIITA.
Useful for expression of tranfected MHC-II genes and alleles.
Technical Summary
The class II transactivator (CIITA) is essential for the expression of major histocompatibility complex class II (MHC-II) genes. However, the role of CIITA...
Published: 9/26/2024
Contributor(s): Jeremy Boss, Christopher (Chris) Scharer
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Spatiotemporal Genomic Analysis to Identify and Extract Rare Cancer Cells
Application
Isolation and analysis of phenotype and genome of rare cell types within a tumor for research and potential diagnostics.
Key Benefits
Allows the identification of a single cell or group of cells within a tumor sample using phenotypic criteria.
Enables both phenotypic and genetic analysis of the same rare cells within a tumor.
Market...
Published: 7/30/2024
Contributor(s): Adam Marcus, Jessica Konen
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Immortalized Mouse Aortic Endothelial Cell Lines
Application
Immortalized (using polyoma middle T-antigen) mouse aortic endothelial primary cell lines for studying vascular biology and pathophysiology, including cardiovascular research.
Key Benefits
Immortalized from mouse artery endothelial cells using polyoma middle T-antigen.
Validated retention of primary endothelial markers and structural...
Published: 9/26/2024
Contributor(s): Hanjoong Jo, Chih-Wen Ni, Sandeep Kumar
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ARCaPE Cell Lines Expressing shRNAs of Human EPLIN
Application
Highly malignant and metastatic prostate cancer cell line.
Key Benefits
Prostate cancer cell line with reduced Epithelial Protein Lost In Neoplasm (EPLIN) expression.
Cell line exhibits morphology characteristics of malignant cell lines and increased chemoresistance, migration, and invasion.
Market Summary
Although the survival...
Published: 9/26/2024
Contributor(s): Daqing Wu, Shumin Zhang
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Pre-B Acute Lymphoblastic Leukemia Cell Line EU-4
Application
Cancer cell line derived from a pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia with myeloid phenotype.
Key Benefits
Does not express p53 and expresses wild-type MDM2.
Expresses wild-type Bax, over-expresses Bcl-xl, and does not express Bcl-2.
Can be used as a tool for gene transfection assays in...
Published: 11/20/2024
Contributor(s): Muxiang Zhou, Lu Bing Gu
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