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Human Induced Pluripotent Stem Cells
ApplicationHuman induced pluripotent stem cells useful for human stem cell biology, Lesch-Nyhan disease or DYT1 dystonia.Technical SummaryLesch-Nyhan syndrome (juvenile gout) is a rare, inherited disorder caused by deficiency in hypoxanthine-guanine phosphoribosyltransferase (HGPRT). The disease causes overproduction of uric acid often leading to gout...
Published: 9/26/2024
Contributor(s): Hyder Jinnah
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CIITA Deficient Human B Cell Line
Application
Human B cell line deficient in class II transactivator (CIITA).
Key Benefits
Deficient in CIITA.
Useful for expression of tranfected MHC-II genes and alleles.
Technical Summary
The class II transactivator (CIITA) is essential for the expression of major histocompatibility complex class II (MHC-II) genes. However, the role of CIITA...
Published: 9/26/2024
Contributor(s): Jeremy Boss, Christopher (Chris) Scharer
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ARCaPE Cell Lines Expressing shRNAs of Human EPLIN
Application
Highly malignant and metastatic prostate cancer cell line.
Key Benefits
Prostate cancer cell line with reduced Epithelial Protein Lost In Neoplasm (EPLIN) expression.
Cell line exhibits morphology characteristics of malignant cell lines and increased chemoresistance, migration, and invasion.
Market Summary
Although the survival...
Published: 9/26/2024
Contributor(s): Daqing Wu, Shumin Zhang
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Pre-B Acute Lymphoblastic Leukemia Cell Line EU-4
Application
Cancer cell line derived from a pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia with myeloid phenotype.
Key Benefits
Does not express p53 and expresses wild-type MDM2.
Expresses wild-type Bax, over-expresses Bcl-xl, and does not express Bcl-2.
Can be used as a tool for gene transfection assays in...
Published: 11/20/2024
Contributor(s): Muxiang Zhou, Lu Bing Gu
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Early Pre-B Acute Lymphoblastic Leukemia Cell Line EU-1
Application
Cancer cell line derived from a relapsed pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia.
Key Benefits
Well-characterized continuous leukemia-lymphoma cell line.
Expresses wild-type p53 and over-expresses MDM2 oncoprotein.
Expresses wild-type Bcl-2, Bcl-xl, and Bax.
Technical Summary
p53 is...
Published: 11/20/2024
Contributor(s): Muxiang Zhou, Lu Bing Gu
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Early Pre-B Acute Lymphoblastic Leukemia Cell Line EU-6
Application
Cancer cell line derived from a relapsed pediatric patient with early B-cell precursor (Pre-B) acute lymphoblastic leukemia.
Key Benefits
Well-characterized to have a point mutation of the p53 gene at codon 273.
Expresses wild-type Bax, Bcl-xl, and Bcl-2.
Well used tool for p53 studies in leukemia.
Technical Summary
p53 is a tumor...
Published: 11/20/2024
Contributor(s): Muxiang Zhou, Lu Bing Gu
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Cancer Cell Lines with LKB1 Depletion
Application
Cancer cell lines (specifically non-small cell lung cancer) with depleted levels of LKB1 protein.
Key Benefits
Multiple cancer cell lines are available.
Produced with lentiviral LKB1 short hairpin RNA constructs.
Technical Summary
LKB1 is a serine/threonine kinase gene located on chromosome 19p13.3 and inactivation of LKB1 is present...
Published: 11/20/2024
Contributor(s): Wei Zhou, Diansheng Zhong
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Genetically Modified Cell Line With Selectively Impaired O-linked Glycosylation
ApplicationGenetically modified cell line which inhibits O-linked glycosylation and produces glycoproteins containing N-linked modifications.Key BenefitsModel system represents epimerase deficiency galactosemia, a variant form of galactosemia.Provides a means to study differing functional mechanisms of N- and O-linked glycosylation.Market SummaryGalactosemia,...
Published: 9/26/2024
Contributor(s): Judith Fridovich-Keil, Monty Krieger, Hazel Holden, James Thoden, Jennifer Schulz
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Norepinephrine Transporter cDNA and Cell Line
Applications
Cloning and studying of the norepinephrine transporter.
Technical Summary
This invention is the first cDNA clone encoding a norepinephrine transporter.
The cDNA allows high-level expression of the transporter in non-neuronal
eukaryotic and prokaryotic systems suitable for isolation of the protein. This
invention has applications...
Published: 9/26/2024
Contributor(s): Randy Blakely
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Mouse Enteric Neuronal Cell Line
Application
Fetal and postnatal enteric neuronal cell lines for use in studying the enteric nervous system.
Technical Summary
We have developed fetal (IM-FEN) and postnatal (IM-PEN) enteric neuronal cell lines with features similar to primary enteric neurons. The IM-FEN and IM-PEN have been passaged 40 times since their isolation and have shown no...
Published: 12/4/2024
Contributor(s): Shanthi Srinivasan
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