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Caspase-3 Deficient MEFs with Mutant Caspase-3 Re-Introduced
Application
Mouse embryonic fibroblast (MEF) line deficient in caspase-3 that are reconstituted with constitutively expressed mutant versions of the protease.
Key Benefits
An immortalized caspase-3-deficient MEF cell line.
Tool to study protease induced apoptosis.
Technical Summary
Emory inventors have discriminated a previously unknown role...
Published: 11/20/2020
Contributor(s): Lawrence Boise, Katelyn Ponder
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HIF/Hypoxia-Reporter Cell Lines
ApplicationHypoxia/Hypoxia-inducible factor 1 (HIF-1) inducible luciferase/LacZ reporter cell lines.Key BenefitExpression of luciferase and beta-galactosidase in response to hypoxia treatment.Technical SummaryEmory University researcher, Erwin Van Meir, has made HIF/hypoxia reporter cell lines by stably transfecting the cells with pBIGL-V6R-HRE-Luc/LacZ...
Published: 1/22/2019
Contributor(s): Erwin Van Meir
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ADGRB3/BAI3-Expressing Cell Lines
ApplicationADGRB3/BAI3 expressing human brain tumor cell lines.Technical SummaryAdhesion G protein coupled receptor B3 (ADGRB3), also called Brain-specific angiogenesis inhibitor 3 (BAI3) is a protein that in humans is encoded by the ADGRB3 gene. Emory University researcher Erwin Van Meir has developed medulloblastoma cell lines DAOY, UW288-1 and PFSK1,...
Published: 1/22/2019
Contributor(s): Erwin Van Meir
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Human Induced Pluripotent Stem Cells
ApplicationHuman induced pluripotent stem cells useful for human stem cell biology, Lesch-Nyhan disease or DYT1 dystonia.Technical SummaryLesch-Nyhan syndrome (juvenile gout) is a rare, inherited disorder caused by deficiency in hypoxanthine-guanine phosphoribosyltransferase (HGPRT). The disease causes overproduction of uric acid often leading to gout...
Published: 3/26/2018
Contributor(s): Hyder Jinnah
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CIITA Deficient Human B Cell Line
ApplicationHuman B cell line deficient in class II transactivator (CIITA).Key BenefitsDeficient in CIITA.Useful for expression of tranfected MHC-II genes and alleles.Technical SummaryThe class II transactivator (CIITA) is essential for the expression of major histocompatibility complex class II (MHC-II) genes. However, the role of CIITA in gene regulation...
Published: 9/22/2017
Contributor(s): Jeremy Boss, Christopher (Chris) Scharer
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Spatiotemporal Genomic Analysis to Identify and Extract Rare Cancer Cells
Application
Isolation and analysis of phenotype and genome of rare cell types within a tumor for research and potential diagnostics.
Key Benefits
Allows the identification of a single cell or group of cells within a tumor sample using phenotypic criteria.
Enables both phenotypic and genetic analysis of the same rare cells within a tumor.
Market...
Published: 7/13/2017
Contributor(s): Adam Marcus, Jessica Konen
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Immortalized Mouse Aortic Endothelial Cell Lines
Application
Immortalized (using polyoma middle T-antigen) mouse aortic endothelial primary cell lines for studying vascular biology and pathophysiology, including cardiovascular research.
Key Benefits
Immortalized from mouse artery endothelial cells using polyoma middle T-antigen.
Validated retention of primary endothelial markers and structural phenotype...
Published: 3/25/2016
Contributor(s): Hanjoong Jo, Chih-Wen Ni, Sandeep Kumar
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Prostate Cancer Cell Lines that Mimic Epithelial–Mesenchymal Transition
Application
Prostate cancer cell lines that can undergo epithelial-mesenchymal transition to investigate metastatic biomarkers or screen therapeutics.
Key Benefits
Two genetically similar, but characteristically distinct prostate cancer cell lines that are either resistant or prone to metastasis.
Mouse models injected with ARCaPE developed bone metastasis...
Published: 6/21/2013
Contributor(s): Shumin Zhang, Lajos Gera, Daqing Wu
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TrkA and TrkB Stably Transfected Murine Cell Lines
Application
Cell lines (T17, T48, and T62) to screen for TrkA and/or TrkB agonists.
Technical Summary
Neurotrophins play an essential role in the development and maintenance of the nervous system. One such neutrophin, nerve growth factor (NGF) binds mainly tyrosine kinase A (TrkA). Docking of TrkA by NGF initiates receptor dimerization, phosphorylation...
Published: 6/6/2013
Contributor(s): Keqiang Ye
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ARCaPE Cell Lines Expressing shRNAs of Human EPLIN
Application
Highly malignant and metastatic prostate cancer cell line.
Key Benefits
Prostate cancer cell line with reduced Epithelial Protein Lost In Neoplasm (EPLIN) expression.
Cell line exhibits morphology characteristics of malignant cell lines and increased chemoresistance, migration, and invasion.
Market Summary
Prostate cancer is the most...
Published: 5/28/2013
Contributor(s): Daqing Wu, Shumin Zhang
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Emory UniversityOffice of Technology Transfer