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Platform for Transducing Target Cells with a Viral Vector
Application System for quickly and efficiently obtaining therapeutic levels of transduction. Key Benefits Uses less viral vector to achieve high gene transfer. Shortens transduction time. Produces clinically relevant gene modified cell numbers. Market Summary Information relay at the molecular level, such as the transcription of RNA into proteins,...
Published: 1/23/2020       Inventor(s): Reginald Tran, Wilbur Lam, Christopher Doering, H. (Harold) Trent Spencer
Reprogramming Human Urine Stem Cells into Vascular Tissue
Application System to generate vascular progenitor cells within naturally constructed (or formed) biomatrices from urine cells. Key Benefits Nearly limitless supply of source cells. Non-invasive method for harvesting source cells. Efficient endothelial cell generation with fewer steps and faster generation time than current standard for differentiating...
Published: 1/23/2020       Inventor(s): Young-Sup Yoon, Young-Doug Sohn, Sang-Ho Lee
DNAzyme Nanoparticles for the Cleavage of RNA
Application Site-selective RNA splicing nanozyme for cleaving and ligating RNA. Key Benefits Can cleave virtually any RNA stem loop. Removes a 19 nucleotide segment from a 67 nucleotide RNA loop with up to 66% efficiency. Technical Summary Modulating RNA can be useful for studying RNA biology, gene knockdown, and regulating RNA splicing. Scientists...
Published: 9/5/2019       Inventor(s): Jessica Petree, Kevin Yehl, Khalid Salaita
IFN╬│ Prelicensing for Improved Mesenchymal Stromal Cell Function Post-Thaw
ApplicationMesenchymal stromal cells (MSC) prelicensed with pro-inflammatory cytokines for improved survival and immunosuppressive properties following cryopreservation.Key BenefitsPreserves the immunosuppressive function of MSCs following thawing.Improves effectiveness of transplanted MSCs following cryopreservation.Market SummaryMesenchymal stromal...
Published: 1/22/2019       Inventor(s): Jacques Galipeau, Raghavan Chinnadurai
PLK1 Inhibitors for the Diagnosis and Treatment of Small Cell Lung Carcinoma (SCLC)
Application Polo Like Kinase 1 (PLK1) inhibitor as a potent treatment strategy for SCLC patients with a specific TP53 mutation. Key Benefits A personalized cell therapy for recurrent SCLC cases. Higher efficiency in TP53 mediated PLK1 inhibition to control carcinoma. PLK1, a predictive biomarker for SCLC diagnosis. Market Summary Lung cancer...
Published: 12/6/2018       Inventor(s): Taofeek Owonikoko
Small Molecules for Development of Cardiac Chamber-Specific Myocytes
ApplicationSmall molecule activators and inhibitors of retinoic acid (RA) to create chamber-specific myocytes from pluripotent stem cells without cell sorting.Key BenefitsProduces highly-enriched, subtype-specific populations of cardiac myocytes.Eliminates need for cell-sorting.Does not require transgenic changes to the human stem cells.Market SummaryCardiovascular...
Published: 11/16/2018       Inventor(s): Hee Cheol Cho, Pengcheng Han
Genetic Mutation in Immune Cells for Infectious Disease and Cancer Therapy
ApplicationConditional epigenetic mutation in CD8+ memory T cells as potential cell therapy for chronic viral infection and personalized cancer treatment.Key BenefitsBlocks DNA methylation in T cells, prolonging the life and enhancing the function of these cells.Results in faster CD62L re-expression during effector to memory cell conversion.Delays or...
Published: 11/14/2018       Inventor(s): Benjamin Youngblood, Rafi Ahmed
hPSC-Derived Endothelial Cell Generation System
ApplicationClinically compatible cell culture system to generate endothelial cells (EC) from human pluripotent stem cells (hPSC).Key BenefitsProduces hPSC-ECs in high yield.Compatible with clinical applications of hPSC-derived endothelial cells.Engrafted cells survive longer (>10 months) than in prior published research (weeks).Market SummaryAccording...
Published: 12/11/2017       Inventor(s): Young-Sup Yoon, Shin-Jeong Lee, Ho-Wook Jun
Platelet Lysate Gel for Wound Healing and Revascularization Therapy
ApplicationPlatelet lysate (PL) gel for localized growth factor delivery, wound healing and as a delivery vehicle for cellular therapies.Key BenefitsIncreases human mesenchymal stem cell (MSC) expansion capacity compared to fetal bovine serum.Derived from human blood products, reducing risk of contamination from foreign organism.Enables use of lower...
Published: 10/26/2017       Inventor(s): Luke Brewster, Scott Robinson, Ian Copland
Microfluidic Device for Increased Viral Transduction Efficiency
ApplicationMicrofluidic chip device for facilitating high throughput viral transduction for gene therapy applications.Key BenefitsImproves surface-to-volume ratio, allowing more efficient contact between lentiviruses and cellsIncreases efficiency while maintaining cell viability of traditional methods.Enables gene transfer for non-adherent cells.Compatible...
Published: 2/7/2017       Inventor(s): Reginald Tran, Wilbur Lam, David Myers, Christopher Doering, H. (Harold) Trent Spencer
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