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High-Throughput Platform for Imaging and Maintaining Cells in Culture
Application This closed-loop platform monitors and maintains traditional cell culture and bioengineered tissues to automate standard and custom cell maintenance protocols, including stem cell differentiations, bioengineered tissue generation, and functional maturation of complex cell cultures. Key Benefits Automation of cell culture maintenance Integration...
Published: 8/25/2021       Contributor(s): Vahid Serpooshan, Ayda Melika, Amir Pourmorteza
CRISPR Based System for Targeted Reduction of Gene Expression
ApplicationA CRISPR based gene silencing system using sequence specific RNA to repress expression of endogenous transcripts.Key BenefitsProvides a platform to target specific mRNA transcripts in both prokaryotic and eukaryotic cells. Potential therapeutic strategy against pathogenic bacteria and viruses. Market SummarySince the discovery of silencing...
Published: 12/10/2020       Contributor(s): David Weiss, Tim (Timothy) Sampson
PNP-based Solid Tumor Therapy in Conjunction with Checkpoint Blockade Inhibitors
Application Treatment of solid tumors combining purine nucleoside phosphorylase (PNP) technology with checkpoint blockade inhibition. Key Benefits Safe and effective method for markedly enhancing checkpoint blockade therapy for refractory tumors. Checkpoint inhibitor therapy is FDA-approved and already in use. Market Summary Checkpoint blockade...
Published: 10/22/2020       Contributor(s): Eric Sorscher, Turang Behbahani, Regina Rab, Annette Ehrhardt, Jeong Hong, Disha Joshi
Galectin-9 Directed CAR T-cells for Overcoming Resistance to Chemotherapy in Hematological Malignancies
Application Anti-human Galectin-9-directed chimeric antigen receptor (CAR) T-cells for treatment of hematological malignancies (B-ALL, T-ALL, and DLBCL) in normal, overweight, and obese patients. Key Benefits Can be used as a stand-alone or in-combination product to treat patients with hematological malignancies, particularly overweight and obese...
Published: 10/13/2020       Contributor(s): Curtis Henry, Miyoung (Mi-Young) Lee, Sunil Raikar, Jamie Hamilton, Anthony Ross
HDAC Inhibitors for Managing Vascular Conditions and Diabetic Peripheral Neuropathies
Application Treatment of diabetic neuropathy using epigenetic modulators, histone deacetylase inhibitors (HDACis), to ameliorate or prevent vascular conditions and neuropathic pains by nerve damages. Key Benefits Reverses or protects against diabetes-induced nerve damages by direct injection of HDACi. Relatively low regulatory risk because many...
Published: 4/24/2020       Contributor(s): Young-Sup Yoon, Ji Woong (Jay) Han, Hyunsuk Shim
Platform for Transducing Target Cells with a Viral Vector
Application System for quickly and efficiently obtaining therapeutic levels of transduction. Key Benefits Uses less viral vector to achieve high gene transfer. Shortens transduction time. Produces clinically relevant gene modified cell numbers. Market Summary Information relay at the molecular level, such as the transcription of RNA into proteins,...
Published: 1/23/2020       Contributor(s): Reginald Tran, Wilbur Lam, Christopher Doering, H. (Harold) Trent Spencer
Cas9 Controlled Gene Activation
Application Flexible system using Cas9 to modulate gene expression. Key Benefits Edits genes by cleaving DNA as well as inhibiting transcription. No need to transfect cells with additional Cas9. Market Summary The CRISPR-Cas9 system is a bacterial adaptive immune system that has been appropriated for genetic engineering. The CRISPR-Cas9 system...
Published: 10/11/2019       Contributor(s): David Weiss, Hannah Ratner
DNAzyme Nanoparticles for the Cleavage of RNA
Application Site-selective RNA splicing nanozyme for cleaving and ligating RNA. Key Benefits Can cleave virtually any RNA stem loop. Removes a 19 nucleotide segment from a 67 nucleotide RNA loop with up to 66% efficiency. Technical Summary Modulating RNA can be useful for studying RNA biology, gene knockdown, and regulating RNA splicing. Scientists...
Published: 9/5/2019       Contributor(s): Jessica Petree, Kevin Yehl, Khalid Salaita
IFN Gamma Prelicensing for Improved Mesenchymal Stromal Cell Function Post-Thaw
ApplicationMesenchymal stromal cells (MSC) prelicensed with pro-inflammatory cytokines for improved survival and immunosuppressive properties following cryopreservation.Key BenefitsPreserves the immunosuppressive function of MSCs following thawing.Improves effectiveness of transplanted MSCs following cryopreservation.Market SummaryMesenchymal stromal...
Published: 1/22/2019       Contributor(s): Jacques Galipeau, Raghavan Chinnadurai
Small Molecules for Development of Cardiac Chamber-Specific Myocytes
Application Small molecule activators and inhibitors of retinoic acid (RA) to create chamber-specific myocytes from pluripotent stem cells without cell sorting. Key Benefits Produces highly-enriched, subtype-specific populations of cardiac myocytes. Eliminates need for cell-sorting. Does not require transgenic changes to the human stem cells. Market...
Published: 11/16/2018       Contributor(s): Hee Cheol Cho, Pengcheng Han
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