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Tumor Specific CD8 T Cell TCR Sequences of HPV-Positive Head and Neck Tumors
­ Application HPV-specific CD8 TCR sequences for the treatment of HPV-positive head and neck cancer by adoptive cell therapy. Key Benefits HPV tumor antigen set is specific for HPV-positive head and neck cancer. Targeting of ‘non-classical’ HPV antigens E2 and E5. Potential to synergize and complement HPV E6/7-specific TCR therapies...
Published: 5/18/2022       Contributor(s): Rafi Ahmed, Christiane Eberhardt, Andreas Wieland
Isolation of Therapeutic cells and Framework for Adoptive Cell Therapies
­ Application Isolation of therapeutic cells and framework for adoptive cell therapies based around stem-like chronic memory CD8 T cells that may be paired with PD-1 blockade. Key Benefits Persistent cell survival and therapeutic efficacy following rechallenge with chronic viral infection and cancer. Strong co-treatment potential with PD-1...
Published: 5/13/2022       Contributor(s): Rafi Ahmed, Daniel Chang
Cytokine Priming and Bead Isolation of CD26high T Cells
­ Application Technique to enrich CD26high T cells for the treatment of solid malignancies. Key Benefits Offers a potent and long-lived T cell product for treating patients with tumors. Can translate into industrial production of cellular therapy products for cancer treatment. Market Summary Melanoma is the deadliest form of skin cancer,...
Published: 4/19/2022       Contributor(s): Michael Brandon Ware, Megan Wyatt, Chrystal Paulos
High-Throughput Platform for Imaging and Maintaining Cells in Culture
Application This closed-loop platform monitors and maintains traditional cell culture and bioengineered tissues to automate standard and custom cell maintenance protocols, including stem cell differentiations, bioengineered tissue generation, and functional maturation of complex cell cultures. Key Benefits Automation of cell culture maintenance Integration...
Published: 8/25/2021       Contributor(s): Vahid Serpooshan, Ayda Melika, Amir Pourmorteza
CRISPR Based System for Targeted Reduction of Gene Expression
ApplicationA CRISPR based gene silencing system using sequence specific RNA to repress expression of endogenous transcripts.Key BenefitsProvides a platform to target specific mRNA transcripts in both prokaryotic and eukaryotic cells. Potential therapeutic strategy against pathogenic bacteria and viruses. Market SummarySince the discovery of silencing...
Published: 12/10/2020       Contributor(s): David Weiss, Tim (Timothy) Sampson
PNP-based Solid Tumor Therapy in Conjunction with Checkpoint Blockade Inhibitors
Application Treatment of solid tumors combining purine nucleoside phosphorylase (PNP) technology with checkpoint blockade inhibition. Key Benefits Safe and effective method for markedly enhancing checkpoint blockade therapy for refractory tumors. Checkpoint inhibitor therapy is FDA-approved and already in use. Market Summary Checkpoint blockade...
Published: 10/22/2020       Contributor(s): Eric Sorscher, Turang Behbahani, Regina Rab, Annette Ehrhardt, Jeong Hong, Disha Joshi
Galectin-9 Directed CAR T-cells for Overcoming Resistance to Chemotherapy in Hematological Malignancies
Application Anti-human Galectin-9-directed chimeric antigen receptor (CAR) T-cells for treatment of hematological malignancies (B-ALL, T-ALL, and DLBCL) in normal, overweight, and obese patients. Key Benefits Can be used as a stand-alone or in-combination product to treat patients with hematological malignancies, particularly overweight and obese...
Published: 10/13/2020       Contributor(s): Curtis Henry, Miyoung (Mi-Young) Lee, Sunil Raikar, Jamie Hamilton, Anthony Ross
HDAC Inhibitors for Managing Vascular Conditions and Diabetic Peripheral Neuropathies
Application Treatment of diabetic neuropathy using epigenetic modulators, histone deacetylase inhibitors (HDACis), to ameliorate or prevent vascular conditions and neuropathic pains by nerve damages. Key Benefits Reverses or protects against diabetes-induced nerve damages by direct injection of HDACi. Relatively low regulatory risk because many...
Published: 4/24/2020       Contributor(s): Young-Sup Yoon, Ji Woong (Jay) Han, Hyunsuk Shim
Platform for Transducing Target Cells with a Viral Vector
Application System for quickly and efficiently obtaining therapeutic levels of transduction. Key Benefits Uses less viral vector to achieve high gene transfer. Shortens transduction time. Produces clinically relevant gene modified cell numbers. Market Summary Information relay at the molecular level, such as the transcription of RNA into proteins,...
Published: 1/23/2020       Contributor(s): Reginald Tran, Wilbur Lam, Christopher Doering, H. (Harold) Trent Spencer
Cas9 Controlled Gene Activation
Application Flexible system using Cas9 to modulate gene expression. Key Benefits Edits genes by cleaving DNA as well as inhibiting transcription. No need to transfect cells with additional Cas9. Market Summary The CRISPR-Cas9 system is a bacterial adaptive immune system that has been appropriated for genetic engineering. The CRISPR-Cas9 system...
Published: 10/11/2019       Contributor(s): David Weiss, Hannah Ratner
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