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Methods for Enhancing MSC Therapeutic Potential for Treatment of Osteoarthritis by Measuring and Targeting Intracellular Pathways
Application
Highly transformative new strategy to enhance mesenchymal stromal cell consistency and efficacy for taking MSC therapies to clinical stage.
Key Benefits
Currently there is no method to determine if an MSC donor line will be therapeutically effective.
Provides a point of use assay in the clinical setting which can determine MSC efficacy...
Published: 5/8/2023
Contributor(s): Nick Willett, Levi Wood, Jay McKinney
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Tumor Specific CD8 T Cell TCR Sequences of HPV-Positive Head and Neck Tumors
Application
HPV-specific CD8 TCR sequences for the treatment of HPV-positive head and neck cancer by adoptive cell therapy.
Key Benefits
HPV tumor antigen set is specific for HPV-positive head and neck cancer.
Targeting of ‘non-classical’ HPV antigens E2 and E5.
Potential to synergize and complement HPV E6/7-specific TCR therapies...
Published: 4/5/2023
Contributor(s): Rafi Ahmed, Christiane Eberhardt, Andreas Wieland
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Isolation of Therapeutic cells and Framework for Adoptive Cell Therapies
Application
Isolation of therapeutic cells and framework for adoptive cell therapies based around stem-like chronic memory CD8 T cells that may be paired with PD-1 blockade.
Key Benefits
Persistent cell survival and therapeutic efficacy following rechallenge with chronic viral infection and cancer.
Strong co-treatment potential with PD-1...
Published: 2/8/2023
Contributor(s): Rafi Ahmed, Daniel Chang
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Cytokine Priming and Bead Isolation of CD26high T Cells
Application
Technique to enrich CD26high T cells for the treatment of solid malignancies.
Key Benefits
Offers a potent and long-lived T cell product for treating patients with tumors.
Can translate into industrial production of cellular therapy products for cancer treatment.
Market Summary
Melanoma accounts for less than 2% of skin cancer...
Published: 4/5/2023
Contributor(s): Michael Brandon Ware, Megan Wyatt, Chrystal Paulos
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High-Throughput Platform for Imaging and Maintaining Cells in Culture
Application
This closed-loop platform monitors and maintains traditional cell culture and bioengineered tissues to automate standard and custom cell maintenance protocols, including stem cell differentiations, bioengineered tissue generation, and functional maturation of complex cell cultures.
Key Benefits
Automation of cell culture maintenance
Integration...
Published: 4/5/2023
Contributor(s): Vahid Serpooshan, Ayda Melika, Amir Pourmorteza
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CRISPR Based System for Targeted Reduction of Gene Expression
Application
A CRISPR based gene silencing system using sequence specific RNA to repress expression of endogenous transcripts.
Key Benefits
Provides a platform to target specific mRNA transcripts in both prokaryotic and eukaryotic cells.
Potential therapeutic strategy against pathogenic bacteria and viruses.
Market Summary
RNAi is an indispensable...
Published: 5/23/2023
Contributor(s): David Weiss, Tim (Timothy) Sampson
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PNP-based Solid Tumor Therapy in Conjunction with Checkpoint Blockade Inhibitors
Application
Treatment of solid tumors combining purine nucleoside phosphorylase (PNP) technology with checkpoint blockade inhibition.
Key Benefits
Safe and effective method for markedly enhancing checkpoint blockade therapy for refractory tumors.
Checkpoint inhibitor therapy is FDA-approved and already in use.
Market Summary
Checkpoint blockade...
Published: 5/10/2023
Contributor(s): Eric Sorscher, Turang Behbahani, Regina Rab, Annette Ehrhardt, Jeong Hong, Disha Joshi
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Galectin-9 Directed CAR T-cells for Overcoming Resistance to Chemotherapy in Hematological Malignancies
Application
Anti-human Galectin-9-directed chimeric antigen receptor (CAR) T-cells for treatment of hematological malignancies (B-ALL, T-ALL, and DLBCL) in normal, overweight, and obese patients.
Key Benefits
Can be used as a stand-alone or in-combination product to treat patients with hematological malignancies, particularly overweight and obese...
Published: 5/4/2023
Contributor(s): Curtis Henry, Miyoung (Mi-Young) Lee, Sunil Raikar, Jamie Hamilton, Anthony Ross
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HDAC Inhibitors for Managing Vascular Conditions and Diabetic Peripheral Neuropathies
Application
Treatment of diabetic neuropathy using epigenetic modulators, histone deacetylase inhibitors (HDACis), to ameliorate or prevent vascular conditions and neuropathic pains by nerve damages.
Key Benefits
Reverses or protects against diabetes-induced nerve damages by direct injection of HDACi.
Relatively low regulatory risk because many...
Published: 4/5/2023
Contributor(s): Young-Sup Yoon, Ji Woong (Jay) Han, Hyunsuk Shim
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Platform for Transducing Target Cells with a Viral Vector
Application
System for quickly and efficiently obtaining therapeutic levels of transduction.
Key Benefits
Uses less viral vector to achieve high gene transfer.
Shortens transduction time.
Produces clinically relevant gene modified cell numbers.
Market Summary
Information relay at the molecular level, such as the transcription of RNA into proteins,...
Published: 2/8/2023
Contributor(s): Reginald Tran, Wilbur Lam, Christopher Doering, H. (Harold) Trent Spencer
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