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Enhanced Delivery and Efficacy of Antisense Drugs via Covalently Linked Nanodisc Scaffolds
Application
A synthetic nanodisc (ND) scaffold for delivering antisense oligonucleotides (ASOs) for the treatment of disease.
Key Benefits
Improved cellular uptake and protein suppression using antisense oligos.
Longer ASO half-life compared to other ASO delivery methods.
Potential to overcome the delivery and efficacy challenges using ASOs for...
Published: 2/13/2025
Contributor(s): Khalid Salaita, Radhika Sharma
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Automated Software to Quantify Breast Arterial Calcifications from Mammograms
Application
Deep learning software for the automated detection and quantification of breast arterial calcifications in screening mammograms.
Key Benefits
Optimized image segmentation accuracy with improved generalizability towards mammograms with and without BAC presence.
Robust ability to quantitate narrow or heavy BAC and/or partial depositions...
Published: 2/13/2025
Contributor(s): Hari Trivedi, Imon Banerjee, William Charles O'Neill, Aisha Urooj Khan, Theodorus Dapamede, Judy Wawira Gichoya
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Multimodal Identification of Atrial Fibrillation Recurrence Sites
Application
Identifies areas of interest associated with atrial fibrillation recurrences.
Key Benefits
Identifies sites associated with recurrences for AF patients.
Predict AF recurrence risk in patients’ post-catheter ablation.
Development of prediction model by extracting features from the surface of interest (SOI).
Market Summary
Atrial...
Published: 2/13/2025
Contributor(s): Abhishek Midya, Anant Madabhushi, Golnoush Asaeikheybari, Mina K. Chung, Amogh Hiremath, Moore Benjamin Shoemaker, Majd A. El-Harasis, John Barnard, Rod S. Passman
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Drug Screening System for Cardioprotection
Application
A high throughput screening assay for developing therapies to protect from drug and alcohol-induced cardiotoxicity.
Key Benefits
A cardiovascular stem-cell-based screening assay that can identify drugs that protect the heart from toxic medications and alcohol.
Preliminary data in the laboratory show the system is clinically relevant...
Published: 2/13/2025
Contributor(s): Chunhui Xu, Antonio Rampoldi, Yuhong Du
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Engineered Biomaterials for Vascular Grafts
Application
A biomaterial to create grafts for treating babies with congenital heart diseases.
Key Benefits
A biocompatible material that can be used to reroute blood within the body.
Experimental data in animals show the material is biocompatible with no clots, thrombus, or adverse immune reactions.
Potential to be used in other cardiovascular...
Published: 2/13/2025
Contributor(s): Saimuralidhar (Murali) Padala, Jahnavi Mudigonda
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Automated Breast Arterial Calcifications Segmentation and Quantification on Mammograms Using Deep Learning
Application
Software for the quantification of breast arterial calcifications on routine mammograms to be used for risk stratification for cardiovascular outcomes.
Key Benefits
Optimized image segmentation accuracy with reduced software complexity.
Integrated calcium scoring.
Screens patients who would not normally be indicated for cardiac...
Published: 2/13/2025
Contributor(s): Hari Trivedi, Imon Banerjee, William Charles O'Neill, Xiaoyuan Guo
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Small Molecules for Development of Cardiac Chamber-Specific Myocytes
Application
Small molecule activators and inhibitors of retinoic acid (RA) to create chamber-specific myocytes from pluripotent stem cells without cell sorting.
Key Benefits
Produces highly-enriched, subtype-specific populations of cardiac myocytes.
Eliminates need for cell-sorting.
Does not require transgenic changes to the human stem cells.
Market...
Published: 2/13/2025
Contributor(s): Hee Cheol Cho, Pengcheng Han
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Reprogramming of Fibroblasts toward a Three-Dimensional Vascularized Cardiomimetic Tissue (CMT)
Application
Fibroblasts reprogrammed into tissue-like patch including functional cardiomyocyte, endothelial, smooth muscle and pericyte cells for treatment of cardiac diseases.
Key Benefits
Enables simultaneous reprogramming of multi-lineage cells including cardiomyocytes and endothelial cells
Increases expression of cardioprotective paracrine...
Published: 2/13/2025
Contributor(s): Young-Sup Yoon, Jaeyeaon Cho
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Immortalized Mouse Aortic Endothelial Cell Lines
Application
Immortalized (using polyoma middle T-antigen) mouse aortic endothelial primary cell lines for studying vascular biology and pathophysiology, including cardiovascular research.
Key Benefits
Immortalized from mouse artery endothelial cells using polyoma middle T-antigen.
Validated retention of primary endothelial markers and structural...
Published: 2/13/2025
Contributor(s): Hanjoong Jo, Chih-Wen Ni, Sandeep Kumar
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Self-Assembling Peptides that Incorporate Cell Signaling Molecules
Application
Platform that creates conjugates of self-assembling peptides and cell signaling molecules as a potential therapeutic for the treatment and repair of tissue.
Key Benefits
Hydrogels form at physiological pH and osmolarity.
Produces cells that display characteristics of adult cardiac muscle cells.
Additional molecules (pro-growth or...
Published: 2/13/2025
Contributor(s): Michael E. Davis, Archana Boopathy
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