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Enhanced Delivery and Efficacy of Antisense Drugs via Covalently Linked Nanodisc Scaffolds
Application
A synthetic nanodisc (ND) scaffold for delivering antisense oligonucleotides (ASOs) for the treatment of disease.
Key Benefits
Improved cellular uptake and protein suppression using antisense oligos.
Longer ASO half-life compared to other ASO delivery methods.
Potential to overcome the delivery and efficacy challenges using ASOs for...
Published: 4/3/2025
Contributor(s): Khalid Salaita, Radhika Sharma
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Automated Software to Quantify Breast Arterial Calcifications from Mammograms
Application
Deep learning software for the automated detection and quantification of breast arterial calcifications in screening mammograms.
Key Benefits
Optimized image segmentation accuracy with improved generalizability towards mammograms with and without BAC presence.
Robust ability to quantitate narrow or heavy BAC and/or partial depositions...
Published: 2/13/2025
Contributor(s): Hari Trivedi, Imon Banerjee, William Charles O'Neill, Aisha Urooj Khan, Theodorus Dapamede, Judy Wawira Gichoya
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Multimodal Identification of Atrial Fibrillation Recurrence Sites
Application
Identifies areas of interest associated with atrial fibrillation recurrences.
Key Benefits
Identifies sites associated with recurrences for AF patients.
Predict AF recurrence risk in patients’ post-catheter ablation.
Development of prediction model by extracting features from the surface of interest (SOI).
Market Summary
Atrial...
Published: 3/6/2025
Contributor(s): Abhishek Midya, Anant Madabhushi, Golnoush Asaeikheybari, Mina K. Chung, Amogh Hiremath, Moore Benjamin Shoemaker, Majd A. El-Harasis, John Barnard, Rod S. Passman
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System for Assessing Health Severity and Predicting Readmissions
Application
A smartphone-based system for monitoring patients to identify and prevent severe cardiac events.
Key Benefits
A remote monitoring system that uses smartphone data to accurately predict a user’s risk for a severe cardiac event (e.g., heart attack).
Tracks the user's movement, location, and physical activity to calculate FDA-accepted...
Published: 3/6/2025
Contributor(s): Gari Clifford, Amit J. Shah, Ayse Cakmak, Erik Reinertsen
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Drug Screening System for Cardioprotection
Application
A high throughput screening assay for developing therapies to protect from drug and alcohol-induced cardiotoxicity.
Key Benefits
A cardiovascular stem-cell-based screening assay that can identify drugs that protect the heart from toxic medications and alcohol.
Preliminary data in the laboratory show the system is clinically relevant...
Published: 3/28/2025
Contributor(s): Chunhui Xu, Antonio Rampoldi, Yuhong Du
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ONC201 for the Treatment of Vascular Aneurysms
Application
A repurposed therapeutic for the preventative and treatment of aneurysms.
Key Benefits
A repurposed cancer drug that targets cells known to be damaged during the progression of an aneurysm.
The drug has been tested within an animal model of aortic aneurysms, where it prevented the severe complications of the disease and protected the...
Published: 3/28/2025
Contributor(s): Alejandra Maria San Martin
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Engineered Biomaterials for Vascular Grafts
Application
A biomaterial to create grafts for treating babies with congenital heart diseases.
Key Benefits
A biocompatible material that can be used to reroute blood within the body.
Experimental data in animals show the material is biocompatible with no clots, thrombus, or adverse immune reactions.
Potential to be used in other cardiovascular...
Published: 2/13/2025
Contributor(s): Saimuralidhar (Murali) Padala, Jahnavi Mudigonda
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Automated Breast Arterial Calcifications Segmentation and Quantification on Mammograms Using Deep Learning
Application
Software for the quantification of breast arterial calcifications on routine mammograms to be used for risk stratification for cardiovascular outcomes.
Key Benefits
Optimized image segmentation accuracy with reduced software complexity.
Integrated calcium scoring.
Screens patients who would not normally be indicated for cardiac...
Published: 2/13/2025
Contributor(s): Hari Trivedi, Imon Banerjee, William Charles O'Neill, Xiaoyuan Guo
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Small Molecules for Development of Cardiac Chamber-Specific Myocytes
Application
Small molecule activators and inhibitors of retinoic acid (RA) to create chamber-specific myocytes from pluripotent stem cells without cell sorting.
Key Benefits
Produces highly-enriched, subtype-specific populations of cardiac myocytes.
Eliminates need for cell-sorting.
Does not require transgenic changes to the human stem cells.
Market...
Published: 3/28/2025
Contributor(s): Hee Cheol Cho, Pengcheng Han
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Biological Pacemakers as Alternatives/Adjuncts to Electronic Pacing Devices
Application
Non-viral gene delivery and a small molecule that converts heart muscle cells to pacemaker cells for the device-free treatment of slow heart rhythm.
Key Benefits
Minimally invasive procedure provides cardiac pacing without device implant.
Restores natural heart rhythm.
Eliminates or reduces significant complications such as repeat...
Published: 4/3/2025
Contributor(s): Hee Cheol Cho, Jun Li
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