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Engineered Biomaterials for Vascular Grafts
Application A biomaterial to create grafts for treating babies with congenital heart diseases. Key Benefits A biocompatible material that can be used to reroute blood within the body. Experimental data in animals show the material is biocompatible with no clots, thrombus, or adverse immune reactions. Potential to be used in other cardiovascular...
Published: 1/10/2024       Contributor(s): Saimuralidhar (Murali) Padala, Jahnavi Mudigonda
Chameleon-Inspired Strain-Accommodating Smart Skin
Application A flexible smart skin that changes its color in response to heat or sunlight. Key Benefits Strain-accommodating. Thermal and photothermal responsive. Light responsive. Highly stretchable. Market Summary Hydrogels are water-insoluble, three-dimensional networks of polymer chains capable of holding large amounts of water. They are...
Published: 12/7/2023       Contributor(s): Khalid Salaita, Yixiao Dong
Functionalized Collagen Biochips with Core-Shell Structures and Collagen-Mimetic Peptide Nanotubes
Application Synthetic collagen-based biomaterials for therapeutic delivery or drug testing. Key Benefits Synthetic collagen substitute. Capable of formulating into various structures. Free of animal-based contaminants. Able to be spatially patterned. Market Summary Organ failure and tissue defects affect millions of Americans, resulting in...
Published: 3/1/2024       Contributor(s): Vincent Conticello, Andrea Merg, Gavin Touponse
TGFβR3-based Biomaterial to Treat Bone Damage
Application PEG-MAL (Poly(ethylene glycol) methyl ether maleimide) polymer gel composition containing soluble TGFβ3R or embedded with modified TGFβ3R over-expressing cells for bone growth and repair therapy. Key Benefits Targets a non-BMP2 signaling pathway to improve BMP signaling. Avoids complications associated with BMP2. Market...
Published: 3/1/2024       Contributor(s): Steven Goudy
Anti-biofouling Polymer for Nanoparticle Coating
Application A functionally amenable copolymer of polyethylene glycol (PEG) and allyl glycidyl ether (AGE) that improves the specificity and targeting of nanoparticles compared to PEG coating. Key Benefits Amphiphilic properties significantly reduce non-specific adsorbtion of proteins compared to PEG. Improves targeting and cell-specific uptake...
Published: 11/27/2023       Contributor(s): Hui Mao, Yuancheng Li, Lily Yang
Collagen-Mimetic Nanosheets
Application Two-dimensional sheets composed of collagen-mimetic peptides on the nanoscale that are highly-ordered and self-assembling. Key Benefits Thermal stability, sheet thickness, and sheet dimensions can be controlled through the peptide sequence and preparative conditions. Market Summary Collagens are used in a number of consumer and biomedical...
Published: 11/6/2023       Contributor(s): Vincent Conticello, Tao Jiang
B10 Protein Polymers to Build Arterial Vascular Grafts
Application B10 protein polymers can be used to build small diameter arterial vascular grafts as well as a host of other potential cardiovascular constructs. The proteins may provide an important vehicle for the design of a variety of medically implanted devices. Technical Summary The emergence of genetically engineered synthetic polypeptides has...
Published: 11/6/2023       Contributor(s): Elliot Chaikof, Vincent Conticello