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Tumor Specific CD8 T Cell TCR Sequences of HPV-Positive Head and Neck Tumors
­ Application HPV-specific CD8 TCR sequences for the treatment of HPV-positive head and neck cancer by adoptive cell therapy. Key Benefits HPV tumor antigen set is specific for HPV-positive head and neck cancer. Targeting of ‘non-classical’ HPV antigens E2 and E5. Potential to synergize and complement HPV E6/7-specific TCR therapies...
Published: 5/18/2022       Contributor(s): Rafi Ahmed, Christiane Eberhardt, Andreas Wieland
CBCT-Guided Adaptive Photon and Proton Radiotherapy
­ Application Generating synthetic MRI images from CBCT images with deep learning. Key Benefits Generate high contrast MRI images from cone-beam CT images. High quality, high contrast images to enable precise radiation treatment. Market Summary Cone-beam computed tomography (CBCT) is an imaging method that produces 3D images of tissues...
Published: 5/18/2022       Contributor(s): Xiaofeng Yang, Yang Lei, Tian Liu, Jun Zhou
Method and Procedure to use 3D Skin Ultrasound to Enhance Cancer and Dermatology Procedures
­ Application A method for generating 3D ultrasound images of skin lesions to improve radiation and dermatology procedures. Key Benefits Generation of high-resolution 3D images of small skin lesions. Ability to work with a variety of high-frequency US probes. Provides guidance to surgeons performing dermatologic procedures. Provides guidance...
Published: 5/18/2022       Contributor(s): Mohammad Khan, Xiaofeng Yang, (Jiwoong) Jason Jeong
Novel Piperidine-Amide Derivatives as CXCR4 Modulators
­ Application A new class of CXCR4 modulators for metastasis and inflammation. Key Benefits Selective for only one allosteric site on CXCR4. Lower adverse effects. Market Summary Multiple myeloma, acute myeloid leukemia, HIV, and rheumatoid arthritis all involve the G-protein receptor CXCR4. Currently, there is only one FDA approved CXCR4...
Published: 5/17/2022       Contributor(s): Hyunsuk Shim, Yoon Oum
Using Antibodies to inhibit Glycoprotein Ib-IX mediated Platelet Signaling and Clearance for the treatment of Thrombocytopenia
­ Application A therapeutic agent to treat thrombocytopenia, the lack of sufficient platelets which can lead to excessive bleeding. Key Benefits This molecule modulates platelet signaling without blocking its ligand binding domain. Its mechanism of action targets a different part of the platelet life cycle from currently available therapeutics. RAM.1...
Published: 5/13/2022       Contributor(s): Renhao Li, Francois Lanza, Wenchun Chen, Moriah Wilson
Treatment of Antimicrobial Resistance Infections
­ Application Novel compounds and peptides for the treatment of antibiotic-resistant infections. Key Benefits Novel mechanism of action that facilitates that killing of GAS in skin keratinocytes. Novel drugs may overcome bacterial resistance to commonly used FDA-approved modifications. Potentially synergy in combination with existing treatments. Possible...
Published: 5/13/2022       Contributor(s): Christopher LaRock, Doris LaRock
Isolation of Therapeutic cells and Framework for Adoptive Cell Therapies
­ Application Isolation of therapeutic cells and framework for adoptive cell therapies based around stem-like chronic memory CD8 T cells that may be paired with PD-1 blockade. Key Benefits Persistent cell survival and therapeutic efficacy following rechallenge with chronic viral infection and cancer. Strong co-treatment potential with PD-1...
Published: 5/13/2022       Contributor(s): Rafi Ahmed, Daniel Chang
Targeting SREBP1 for Managing Acquired Resistance to Osimertinib/AZD9291 and Other EGFR Inhibitors for Non-small Cell Lung Cancer Treatment
­ Application Small molecule combination therapy (adjuvant, sensitizing agent) for Osimertinib (to treat non-small cell lung cancer with common EGFR activating mutations and T790M resistant mutation). Key Benefits Therapy against EGFR-TKI resistant tumors with mutant EGFR (e.g., T790M). Market Summary Non-small cell lung cancer (NSCLC)...
Published: 5/13/2022       Contributor(s): Shi-Yong Sun, Zhen Chen
Adenosine Gel to Treat Inflammation
­ Application Hydrogel to treat inflammation after cardiac injury, pericarditis, myocardial infarction, and myocarditis. Key Benefits Minimally invasive. Increases levels of adenosine in target tissues. Can be applied to other organs such as liver and kidneys. Could be used to promote hair and nail growth. Market Summary Neutrophil extracellular...
Published: 5/13/2022       Contributor(s): Rebecca Levit, Andres Garcia
Small Molecule Compound to Treat Neurological Diseases
­ Application Neurological disease treatment. Key Benefits Exemplary compound EU1180-490 is a potent and selective potentiator of GluN1/GluN3 NMDARs. The compound has excellent Lipinski drug-like properties including low molecular weight and cLogP, as well as water solubility. The initial studies have determined that the compound can penetrate...
Published: 5/13/2022       Contributor(s): Dennis Liotta, Stephen Traynelis, Hongjie Yuan, Matthew Epplin, Samantha Summer, David Menaldino, Leon Jacobs, Adam McCallum
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