|
Liquid-hydrogel Hybrid Microfluidic Device
Application
Measurement device for detecting of single-cell dynamics under environment perturbations or drug treatment.
Key Benefits
Fast determination of drug sensitivity.
Long-term continuous cell-fate tracking.
Time-lapse analysis of cell proliferation.
Cell community analysis: intra-species interactions, inter-species interactions.
Market...
Published: 12/20/2022
Contributor(s): Kyle Allison, Xin Fang, Devina Puri
|
|
Methods for Enhancing MSC Therapeutic Potential for Treatment of Osteoarthritis by Measuring and Targeting Intracellular Pathways
Application
Highly transformative new strategy to enhance mesenchymal stromal cell consistency and efficacy for taking MSC therapies to clinical stage.
Key Benefits
Currently there is no method to determine if an MSC donor line will be therapeutically effective.
Provides a point of use assay in the clinical setting which can determine MSC...
Published: 1/10/2023
Contributor(s): Nick Willett, Levi Wood, Jay McKinney
|
|
Imaging and Tracking mRNA in Live Mammalian Cells via Fluorogenic Photoaffinity Labeling
Application
An improved method for labeling and imagine RNA in live cells.
Key Benefits
Low background signal.
Covalent binding suitable for time-resolved investigations.
Photoactivatable for temporal control.
Market Summary
Ribonucleic acid (RNA) molecules are synthesized in cells through highly regulated biogenesis pathways, and when...
Published: 9/29/2022
Contributor(s): Tewoderos Ayele, Jennifer Heemstra
|
|
A Method of Using Responsive Micro and Sub-micro Scale Polymer Particles for Mechanical Manipulation of Molecules
Application
A method to study the mechanical/controlled unfolding of biomolecules using a polymer force clamp (PFC).
Key Benefits
Particles can be immobilized onto virtually any type of support.
Particles can also be functionalized with a variety of small-molecule, peptide and protein ligands.
Ability to have multiple PFC’s measuring...
Published: 12/6/2022
Contributor(s): Hanquan Su, Khalid Salaita
|
|
BG505 SOSIP Vaccine Elicited Neutralizing Monoclonal Antibodies for HIV
Application
ELISA
Western Blot
Immunohistochemistry
Specficity
HIV-1 BG505 Env protein (clone name: YRK01, YRK02).
Subtype
Monoclonal antibody.
Immunogen
HIV-1 BG505 SOSIP Env trimer.
Technical Summary
HIV-1 envelope glycoprotein (Env) is a membrane protein complex involved in receptor recognition and viral fusion with CD4+ T cells...
Published: 9/29/2022
Contributor(s): Cynthia Derdeyn, Tysheena Charles
|
|
HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform
Application
High Throughput Screening for identifying effective immuno-modulators.
Key Benefits
HT screening platform replicating complex immune medicated response to facilitate discovery of small molecule immunomodulatory agents.
Simplicity and dual readouts of the design enable the screening of large chemical libraries to identify compounds...
Published: 9/29/2022
Contributor(s): Xiulei Mo, Haian Fu
|
|
Tyrosinase Viral Vectors for the Generation of Rodents Exhibiting Time -Dependent Production and Intracellular Accumulation of Human-Like Neuromelanin
Application
Improved study of neurodegenerative diseases on mice.
Key Benefits
Ability to study neuromelanin’s association with neurodegenerative diseases with mice.
Researchers can analyze overexpression of tyrosinase on specific cell types.
Market Summary
Neurodegenerative diseases such as Alzheimer’s and Parkinson’s...
Published: 9/29/2022
Contributor(s): David Weinshenker, Alexa Iannitelli
|
|
Tool for Assessing LGBTQI+ Health Training (TALHT) in Pre-licensure Nursing Curricula
Application
A tool for assessing health training in nursing curricula.
Key Benefits
This tool consists of a form that contains categories and specific domains for assessment accompanied by a scoring system to provide an accounting in each category.
Simplicity of design, this tool can easily be self-administered by nursing faculty and administrators.
Provides...
Published: 8/26/2022
Contributor(s): Athena Sherman, Kelly Bower, Meredith Klepper, Angie Deng
|
|
Cryopreservation and CO2-independent Culture of 3D Cardiac Progenitors for Space Flight Experiments
Application
New method for developing therapeutic stem cells that could repair damaged heart tissue.
Key Benefits
Potentially improves the ability to generate cardiomyocytes from hiPSCs compared to current methods.
It may be used for the treatment and/or repair of diseases that damage the heart tissue.
Culture improvements could apply...
Published: 10/28/2022
Contributor(s): Chunhui Xu, Antonio Rampoldi, Rajneesh Jha
|
|
A New Method to Detect and Tackle Antibiotic Heteroresistance
Application
A method to detect heteroresistance to antibiotics in bacteria.
Key Benefits
Significantly faster than commercially available options.
Aside from the interferometer itself, no specialized reagents are required.
Inexpensive to use.
Market Summary
Antibiotic resistance is a significant threat to public health. Rapid and sensitive...
Published: 1/10/2023
Contributor(s): David Weiss, Peter Yunker, David Hufnagel, Arben (Ben) Kalziqi
|