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BG505 SOSIP Vaccine Elicited Neutralizing Monoclonal Antibodies for HIV
­ Application ELISA Western Blot Immunohistochemistry Specficity HIV-1 BG505 Env protein (clone name: YRK01, YRK02). Subtype Monoclonal antibody. Immunogen HIV-1 BG505 SOSIP Env trimer. Technical Summary HIV-1 envelope glycoprotein (Env) is a membrane protein complex involved in receptor recognition and viral fusion with CD4+ T cells...
Published: 5/17/2022       Contributor(s): Cynthia Derdeyn, Tysheena Charles
HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform
­ Application High Throughput Screening for identifying effective immuno-modulators. Key Benefits HT screening platform replicating complex immune medicated response to facilitate discovery of small molecule immunomodulatory agents. Simplicity and dual readouts of the design enable the screening of large chemical libraries to identify compounds...
Published: 5/17/2022       Contributor(s): Xiulei Mo, Haian Fu
Tyrosinase Viral Vectors for the Generation of Rodents Exhibiting Time -Dependent Production and Intracellular Accumulation of Human-Like Neuromelanin
­ Application Improved study of neurodegenerative diseases on mice. Key Benefits Ability to study neuromelanin’s association with neurodegenerative diseases with mice. Researchers can analyze overexpression of tyrosinase on specific cell types. Market Summary Neurodegenerative diseases such as Alzheimer’s and Parkinson’s...
Published: 5/13/2022       Contributor(s): David Weinshenker, Alexa Iannitelli
Tool for Assessing LGBTQI+ Health Training (TALHT) in Pre-licensure Nursing Curricula
­ Application A tool for assessing health training in nursing curricula. Key Benefits This tool consists of a form that contains categories and specific domains for assessment accompanied by a scoring system to provide an accounting in each category. Simplicity of design, this tool can easily be self-administered by nursing faculty and administrators. Provides...
Published: 5/13/2022       Contributor(s): Athena Sherman, Kelly Bower, Meredith Klepper, Angie Deng
Cryopreservation and CO2-independent Culture of 3D Cardiac Progenitors for Space Flight Experiments
­ Application New method for developing therapeutic stem cells that could repair damaged heart tissue. Key Benefits Potentially improves the ability to generate cardiomyocytes from hiPSCs compared to current methods. It may be used for the treatment and/or repair of diseases that damage the heart tissue. Culture improvements could apply...
Published: 3/16/2022       Contributor(s): Chunhui Xu, Antonio Rampoldi, Rajneesh Jha
A New Method to Detect and Tackle Antibiotic Heteroresistance
­ Application A method to detect heteroresistance to antibiotics in bacteria. Key Benefits Significantly faster than commercially available options. Aside from the interferometer itself, no specialized reagents are required. Inexpensive to use. Market Summary Antibiotic resistance is a significant threat to public health. One estimate...
Published: 1/10/2022       Contributor(s): David Weiss, Peter Yunker, David Hufnagel, Arben (Ben) Kalziqi
Biocompatible Nanoreporter for Measuring Fluidic Shear Stress
­ Application A research tool for quantifying fluidic shear stress in vitro and in vivo. Key Benefits Directly measures sub-cellular shear stress from 0.5 dynes/cm2 to 100 dynes/cm2. Can target specific ligands of interest. Compatible with existing fluorescent approaches. Flexible design allows for multiple modifications for a variety of...
Published: 12/2/2021       Contributor(s): David Myers, Yonggang Ke, Victor Pan, Shreyas Dahotre, Gabriel (Gabe) Kwong
High-Throughput Platform for Imaging and Maintaining Cells in Culture
Application This closed-loop platform monitors and maintains traditional cell culture and bioengineered tissues to automate standard and custom cell maintenance protocols, including stem cell differentiations, bioengineered tissue generation, and functional maturation of complex cell cultures. Key Benefits Automation of cell culture maintenance Integration...
Published: 8/25/2021       Contributor(s): Vahid Serpooshan, Ayda Melika, Amir Pourmorteza
Multimodal Prospective Learning Test
Application Multimodal learning test to assess naming and facial recognition in post-operative epilepsy patients. Key Benefits Provides non-invasive, age-appropriate neuropsychological testing. Allows clinicians to simultaneously assess multiple modalities. Market Summary Epilepsy is a chronic neurological disorder characterized by unpredictable,...
Published: 12/10/2020       Contributor(s): Daniel (Dan) Drane, Keith Adams
CRISPR Based System for Targeted Reduction of Gene Expression
ApplicationA CRISPR based gene silencing system using sequence specific RNA to repress expression of endogenous transcripts.Key BenefitsProvides a platform to target specific mRNA transcripts in both prokaryotic and eukaryotic cells. Potential therapeutic strategy against pathogenic bacteria and viruses. Market SummarySince the discovery of silencing...
Published: 12/10/2020       Contributor(s): David Weiss, Tim (Timothy) Sampson
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