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3D-Printed Mouse Headplates for Implantation of EEG, EMG and Depth Electrodes
Application
Tool to precisely and reproducibly implant electrode and other instrumentation into the mouse brain for neurophysiology studies.
Key Benefits
Inexpensive, rapid and efficient reproduction of headplates.
Allows consistent and quick surgical implantation.
Capable of recording or stimulating multiple sites in the mouse brain.
Market...
Published: 5/21/2020
Inventor(s): Nigel Pedersen, Lauren Aiani
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Ribosome Pegging: An Antibiotic-free System to Produce Recombinant Proteins
Application
Antibiotic-free method to prevent the growth of cells that fail to express high levels of a non-essential protein (target protein).
Key Benefits
Prevents the use of antibiotics and markers that promote resistance.
Facilitates the deployment of recombinant bacteria in uncontrolled environments.
Stabilizes heterologous expression of...
Published: 4/22/2020
Inventor(s): Ichiro Matsumura
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Molecular Probe that Records Mechanical Information Produced by Living Cells
Application
A molecular probe that stores and integrates short-lived cellular mechanical events over time.
Key Benefits
Quantitative method of measuring short-lived interactions between cells.
Ideal for immunology-based assays
Fluorescence-based and amenable as a drug screening research tool.
Market Summary
Studying the interplay between mechanical...
Published: 2/27/2020
Inventor(s): Khalid Salaita, Rong Ma
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Platform for Transducing Target Cells with a Viral Vector
Application
System for quickly and efficiently obtaining therapeutic levels of transduction.
Key Benefits
Uses less viral vector to achieve high gene transfer.
Shortens transduction time.
Produces clinically relevant gene modified cell numbers.
Market Summary
Information relay at the molecular level, such as the transcription of RNA into proteins,...
Published: 1/23/2020
Inventor(s): Reginald Tran, Wilbur Lam, Christopher Doering, H. (Harold) Trent Spencer
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Reprogramming Human Urine Stem Cells into Vascular Tissue
Application
System to generate vascular progenitor cells within naturally constructed (or formed) biomatrices from urine cells.
Key Benefits
Nearly limitless supply of source cells.
Non-invasive method for harvesting source cells.
Efficient endothelial cell generation with fewer steps and faster generation time than current standard for differentiating...
Published: 1/23/2020
Inventor(s): Young-Sup Yoon, Young-Doug Sohn, Sang-Ho Lee
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Strategy to Identify miRNAs for Disease Diagnosis
Application
Method to measure precursor and mature miRNA specifically.
Key Benefits
Unique primers can specifically identify miRNAs and precursor miRNAs by standard qRT-PCR without the requirement for an additional detection probe.
Allows for amplification and quantification of both mature miRNA and precursor miRNAs.
Potential technology to evaluate...
Published: 1/22/2020
Inventor(s): Wenming Li
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Real-time, Particle-Tracking and Control Software for Electromagnetic Tweezers
Application
Software to control electromagnetic tweezers and to track tethered particles in real-time in 3D.
Key Benefits
Electromagnets offer improved temporal response without mechanical vibration.
3D particle tracking utilizing a continuous LUT built from multidimensional spline fits of discrete data improves accuracy and provides precision...
Published: 1/14/2020
Inventor(s): Daniel Kovari, David Dunlap, Laura Finzi
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Psychosis Prediction Using Speech Patterns
Application
Linguistic software to predict and diagnose psychosis.
Key Benefits
New method of diagnosing psychosis.
Very high accuracy rate (86.7%).
Market Summary
Psychotic disorders are mental illnesses characterized by delusions, hallucinations, and disorganized thinking and speaking. Schizophrenia is an example of a psychotic disorder....
Published: 1/14/2020
Inventor(s): Phillip Wolff, Jinho Choi
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High-Resolution Field Inhomogeneity Correction for Magnetic Resonance Spectroscopy
Application
Post-processing algorithm to correct field inhomogeneity in MR spectroscopy.
Key Benefits
Subvoxel field inhomogeneity correction enables CEST magnetic resonance imaging (MRI) Z-spectrum from body tissues where shimming is challenging.
Intravoxel field inhomogeneity correction enables MR spectroscopy (MRS) and MR spectroscopy imaging...
Published: 1/13/2020
Inventor(s): Phillip Zhe Sun
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Selective Enrichment of A-To-I Edited Transcripts from Cellular RNA Using Endonuclease V
Application
Kit to efficiently identify and enrich adenosine-to-inosine (A-to-I) editing in RNA molecules.
Key Benefits
Robust and facile method for enriching A-to-I edited transcripts.
Overcomes the low efficiency and accuracy of transcriptome-wide RNA-seq.
Market Summary
A-to-I RNA editing by adenosine deaminases is a common RNA modification...
Published: 12/3/2019
Inventor(s): Steven Knutson, Jennifer (Jen) Heemstra
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Emory UniversityOffice of Technology Transfer