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Liquid-hydrogel Hybrid Microfluidic Device
Application Measurement device for detecting of single-cell dynamics under environment perturbations or drug treatment. Key Benefits Fast determination of drug sensitivity. Long-term continuous cell-fate tracking. Time-lapse analysis of cell proliferation. Cell community analysis: intra-species interactions, inter-species interactions. Market...
Published: 12/20/2022       Contributor(s): Kyle Allison, Xin Fang, Devina Puri
Methods for Enhancing MSC Therapeutic Potential for Treatment of Osteoarthritis by Measuring and Targeting Intracellular Pathways
­ Application Highly transformative new strategy to enhance mesenchymal stromal cell consistency and efficacy for taking MSC therapies to clinical stage. Key Benefits Currently there is no method to determine if an MSC donor line will be therapeutically effective. Provides a point of use assay in the clinical setting which can determine MSC...
Published: 1/10/2023       Contributor(s): Nick Willett, Levi Wood, Jay McKinney
Imaging and Tracking mRNA in Live Mammalian Cells via Fluorogenic Photoaffinity Labeling
­ Application An improved method for labeling and imagine RNA in live cells. Key Benefits Low background signal. Covalent binding suitable for time-resolved investigations. Photoactivatable for temporal control. Market Summary Ribonucleic acid (RNA) molecules are synthesized in cells through highly regulated biogenesis pathways, and when...
Published: 9/29/2022       Contributor(s): Tewoderos Ayele, Jennifer Heemstra
A Method of Using Responsive Micro and Sub-micro Scale Polymer Particles for Mechanical Manipulation of Molecules
­ Application A method to study the mechanical/controlled unfolding of biomolecules using a polymer force clamp (PFC). Key Benefits Particles can be immobilized onto virtually any type of support. Particles can also be functionalized with a variety of small-molecule, peptide and protein ligands. Ability to have multiple PFC’s measuring...
Published: 12/6/2022       Contributor(s): Hanquan Su, Khalid Salaita
BG505 SOSIP Vaccine Elicited Neutralizing Monoclonal Antibodies for HIV
­ Application ELISA Western Blot Immunohistochemistry Specficity HIV-1 BG505 Env protein (clone name: YRK01, YRK02). Subtype Monoclonal antibody. Immunogen HIV-1 BG505 SOSIP Env trimer. Technical Summary HIV-1 envelope glycoprotein (Env) is a membrane protein complex involved in receptor recognition and viral fusion with CD4+ T cells...
Published: 9/29/2022       Contributor(s): Cynthia Derdeyn, Tysheena Charles
HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform
­ Application High Throughput Screening for identifying effective immuno-modulators. Key Benefits HT screening platform replicating complex immune medicated response to facilitate discovery of small molecule immunomodulatory agents. Simplicity and dual readouts of the design enable the screening of large chemical libraries to identify compounds...
Published: 9/29/2022       Contributor(s): Xiulei Mo, Haian Fu
Tyrosinase Viral Vectors for the Generation of Rodents Exhibiting Time -Dependent Production and Intracellular Accumulation of Human-Like Neuromelanin
­ Application Improved study of neurodegenerative diseases on mice. Key Benefits Ability to study neuromelanin’s association with neurodegenerative diseases with mice. Researchers can analyze overexpression of tyrosinase on specific cell types. Market Summary Neurodegenerative diseases such as Alzheimer’s and Parkinson’s...
Published: 9/29/2022       Contributor(s): David Weinshenker, Alexa Iannitelli
Tool for Assessing LGBTQI+ Health Training (TALHT) in Pre-licensure Nursing Curricula
­ Application A tool for assessing health training in nursing curricula. Key Benefits This tool consists of a form that contains categories and specific domains for assessment accompanied by a scoring system to provide an accounting in each category. Simplicity of design, this tool can easily be self-administered by nursing faculty and administrators. Provides...
Published: 8/26/2022       Contributor(s): Athena Sherman, Kelly Bower, Meredith Klepper, Angie Deng
Cryopreservation and CO2-independent Culture of 3D Cardiac Progenitors for Space Flight Experiments
­ Application New method for developing therapeutic stem cells that could repair damaged heart tissue. Key Benefits Potentially improves the ability to generate cardiomyocytes from hiPSCs compared to current methods. It may be used for the treatment and/or repair of diseases that damage the heart tissue. Culture improvements could apply...
Published: 10/28/2022       Contributor(s): Chunhui Xu, Antonio Rampoldi, Rajneesh Jha
A New Method to Detect and Tackle Antibiotic Heteroresistance
­ Application A method to detect heteroresistance to antibiotics in bacteria. Key Benefits Significantly faster than commercially available options. Aside from the interferometer itself, no specialized reagents are required. Inexpensive to use. Market Summary Antibiotic resistance is a significant threat to public health. Rapid and sensitive...
Published: 1/10/2023       Contributor(s): David Weiss, Peter Yunker, David Hufnagel, Arben (Ben) Kalziqi
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