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Multimodal Prospective Learning Test
Application
Multimodal learning test to assess naming and facial recognition in post-operative epilepsy patients.
Key Benefits
Provides non-invasive, age-appropriate neuropsychological testing.
Allows clinicians to simultaneously assess multiple modalities.
Market Summary
Epilepsy is a chronic neurological disorder characterized by unpredictable,...
Published: 12/10/2020
Contributor(s): Daniel Drane, Keith Adams
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CRISPR Based System for Targeted Reduction of Gene Expression
ApplicationA CRISPR based gene silencing system using sequence specific RNA to repress expression of endogenous transcripts.Key BenefitsProvides a platform to target specific mRNA transcripts in both prokaryotic and eukaryotic cells. Potential therapeutic strategy against pathogenic bacteria and viruses. Market SummarySince the discovery of silencing...
Published: 12/10/2020
Contributor(s): David Weiss, Tim (Timothy) Sampson
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Caspase-3 Deficient MEFs with Mutant Caspase-3 Re-Introduced
Application
Mouse embryonic fibroblast (MEF) line deficient in caspase-3 that are reconstituted with constitutively expressed mutant versions of the protease.
Key Benefits
An immortalized caspase-3-deficient MEF cell line.
Tool to study protease induced apoptosis.
Technical Summary
Emory inventors have discriminated a previously unknown role...
Published: 11/20/2020
Contributor(s): Lawrence Boise, Katelyn Ponder
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tPAINT to Measure Molecular Forces in Live Cells
Application
DNA-based probes to measure the nanoscale distribution of piconewton molecular forces in live cells.
Key Benefits
Provides maps of integrin tension with up to ˜25 nm resolution and piconewton force sensitivity for live-cell imaging.
The tPAINT can be performed on a commercial TIRF microscope.
Market Summary
Emory inventors...
Published: 11/17/2020
Contributor(s):
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Additives that Increase Storage and Shelf Life of Platelets
Application
Monoclonal antibody additive that inhibits ectodomain shedding of a platelet glycoprotein to improve platelet storage.
Key Benefits
Current storage techniques allows for limited storage times (5-7 days).
New additive may enable platelet storage at 4°C, increase platelet storage time, and improve quality of stored platelets.
Inhibits...
Published: 11/2/2020
Contributor(s): Renhao Li
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Hemophilia-Related Distress Questionnaire
Application
Instrument to quantitatively measure distress associated with hemophilia and its management.
Key Benefits
Concise, easy to score, and multi-factorial test.
Consistent test-retest reliability.
Promotes improved patient health outcomes.
Market Summary
In the US, approximately 400 babies per year are born with hemophilia and there...
Published: 10/19/2020
Contributor(s): Shanna Mattis, Mary Lynch (O'Neill)
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3D-Printed Mouse Headplates for Implantation of EEG, EMG and Depth Electrodes
Application
Tool to precisely and reproducibly implant electrode and other instrumentation into the mouse brain for neurophysiology studies.
Key Benefits
Inexpensive, rapid and efficient reproduction of headplates.
Allows consistent and quick surgical implantation.
Capable of recording or stimulating multiple sites in the mouse brain.
Market...
Published: 5/21/2020
Contributor(s): Nigel Pedersen, Lauren Aiani
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Ribosome Pegging: An Antibiotic-free System to Produce Recombinant Proteins
Application
Antibiotic-free method to prevent the growth of cells that fail to express high levels of a non-essential protein (target protein).
Key Benefits
Prevents the use of antibiotics and markers that promote resistance.
Facilitates the deployment of recombinant bacteria in uncontrolled environments.
Stabilizes heterologous expression of...
Published: 4/22/2020
Contributor(s):
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Molecular Probe that Records Mechanical Information Produced by Living Cells
Application
A molecular probe that stores and integrates short-lived cellular mechanical events over time.
Key Benefits
Quantitative method of measuring short-lived interactions between cells.
Ideal for immunology-based assays
Fluorescence-based and amenable as a drug screening research tool.
Market Summary
Studying the interplay between mechanical...
Published: 2/27/2020
Contributor(s): Khalid Salaita, Rong Ma
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Platform for Transducing Target Cells with a Viral Vector
Application
System for quickly and efficiently obtaining therapeutic levels of transduction.
Key Benefits
Uses less viral vector to achieve high gene transfer.
Shortens transduction time.
Produces clinically relevant gene modified cell numbers.
Market Summary
Information relay at the molecular level, such as the transcription of RNA into proteins,...
Published: 1/23/2020
Contributor(s): Reginald Tran, Wilbur Lam, Christopher Doering, H. (Harold) Trent Spencer
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Emory UniversityOffice of Technology Transfer