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Machine Learning Diagnostic for Automated Identification and Classification of Bone Marrow Cells
Application Machine learning tool to aid in the diagnosis of hematologic disorders of bone marrow. Key Benefits Automated machine learning-based approach for performing bone marrow differential counts that accounts for all viable cells on the smear. Data generated by a prototype shows the system is fast and demonstrates precision compared to manual...
Published: 8/31/2023       Contributor(s): Lee Cooper, David Gutman, David Jaye, Ahmed Aljudi, Ramraj Chandradevan
Improved Clinical Diagnostic Method for SARS-CoV-2 Infection
Application A more reliable and accurate method for diagnosing SARS-CoV-2 infection based on the biochemical interactions between the spike trimer and ACE-2 protein. Key Benefits A fast, affordable, and easy-to-use SARS-Cov-2 diagnostic test for use in clinical settings. Market Summary SARS-CoV-2 has evolved significantly since the onset of...
Published: 7/28/2023       Contributor(s): John Roback, Andrew Neish, Narayanaiah Cheedarla, Hans Verkerke, Huixia Wu, William Osick, Kaleb Mclendon, Sindhu Potlapalli
Whole-Animal Genetic Model to Mimic Aspects of the Patient Phenotype of Classic Galactosemia
­ Application An animal model for studying the underlying causes of galactosemia and screening for novel drugs to treat the condition. Key Benefits The first animal model for elucidating the underlying causes of galactosemia in infants. Animals with galactosemia causing genetic knockout exhibit similar disease phenotypes and complications...
Published: 7/28/2023       Contributor(s): Judith Fridovich-Keil
Liquid-hydrogel Hybrid Microfluidic Device
Application Measurement device for detecting of single-cell dynamics under environment perturbations or drug treatment. Key Benefits Fast determination of drug sensitivity. Long-term continuous cell-fate tracking. Time-lapse analysis of cell proliferation. Cell community analysis: intra-species interactions, inter-species interactions. Market...
Published: 9/26/2023       Contributor(s): Kyle Allison, Xin Fang, Devina Puri
Methods for Enhancing MSC Therapeutic Potential for Treatment of Osteoarthritis by Measuring and Targeting Intracellular Pathways
Application Highly transformative new strategy to enhance mesenchymal stromal cell consistency and efficacy for taking MSC therapies to clinical stage. Key Benefits Currently there is no method to determine if an MSC donor line will be therapeutically effective. Provides a point of use assay in the clinical setting which can determine MSC efficacy...
Published: 9/26/2023       Contributor(s): Nick Willett, Levi Wood, Jay McKinney
Imaging and Tracking mRNA in Live Mammalian Cells via Fluorogenic Photoaffinity Labeling
Application An improved method for labeling and imagine RNA in live cells. Key Benefits Low background signal. Covalent binding suitable for time-resolved investigations. Photoactivatable for temporal control. Market Summary Ribonucleic acid (RNA) molecules are synthesized in cells through highly regulated biogenesis pathways, and when these...
Published: 9/15/2023       Contributor(s): Tewoderos Ayele, Jennifer Heemstra
A Method of Using Responsive Micro and Sub-micro Scale Polymer Particles for Mechanical Manipulation of Molecules
Application A method to study the mechanical/controlled unfolding of biomolecules using a polymer force clamp (PFC). Key Benefits Particles can be immobilized onto virtually any type of support. Particles can also be functionalized with a variety of small-molecule, peptide and protein ligands. Ability to have multiple PFC’s measuring associated...
Published: 7/28/2023       Contributor(s): Hanquan Su, Khalid Salaita
BG505 SOSIP Vaccine Elicited Neutralizing Monoclonal Antibodies for HIV
­ Application ELISA Western Blot Immunohistochemistry Specficity HIV-1 BG505 Env protein (clone name: YRK01, YRK02). Subtype Monoclonal antibody. Immunogen HIV-1 BG505 SOSIP Env trimer. Technical Summary HIV-1 envelope glycoprotein (Env) is a membrane protein complex involved in receptor recognition and viral fusion with CD4+ T cells...
Published: 7/28/2023       Contributor(s): Cynthia Derdeyn, Tysheena Charles
HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform
­ Application High Throughput Screening for identifying effective immuno-modulators. Key Benefits HT screening platform replicating complex immune medicated response to facilitate discovery of small molecule immunomodulatory agents. Simplicity and dual readouts of the design enable the screening of large chemical libraries to identify compounds...
Published: 7/28/2023       Contributor(s): Xiulei Mo, Haian Fu
Tyrosinase Viral Vectors for the Generation of Rodents Exhibiting Time -Dependent Production and Intracellular Accumulation of Human-Like Neuromelanin
­ Application Improved study of neurodegenerative diseases on mice. Key Benefits Ability to study neuromelanin’s association with neurodegenerative diseases with mice. Researchers can analyze overexpression of tyrosinase on specific cell types. Market Summary Neurodegenerative diseases such as Alzheimer’s and Parkinson’s...
Published: 7/28/2023       Contributor(s): David Weinshenker, Alexa Iannitelli
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