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Machine Learning Diagnostic for Automated Identification and Classification of Bone Marrow Cells
Application
Machine learning tool to aid in the diagnosis of hematologic disorders of bone marrow.
Key Benefits
Automated machine learning-based approach for performing bone marrow differential counts that accounts for all viable cells on the smear.
Data generated by a prototype shows the system is fast and demonstrates precision compared to manual...
Published: 8/31/2023
Contributor(s): Lee Cooper, David Gutman, David Jaye, Ahmed Aljudi, Ramraj Chandradevan
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Improved Clinical Diagnostic Method for SARS-CoV-2 Infection
Application
A more reliable and accurate method for diagnosing SARS-CoV-2 infection based on the biochemical interactions between the spike trimer and ACE-2 protein.
Key Benefits
A fast, affordable, and easy-to-use SARS-Cov-2 diagnostic test for use in clinical settings.
Market Summary
SARS-CoV-2 has evolved significantly since the onset of...
Published: 7/28/2023
Contributor(s): John Roback, Andrew Neish, Narayanaiah Cheedarla, Hans Verkerke, Huixia Wu, William Osick, Kaleb Mclendon, Sindhu Potlapalli
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Whole-Animal Genetic Model to Mimic Aspects of the Patient Phenotype of Classic Galactosemia
Application
An animal model for studying the underlying causes of galactosemia and screening for novel drugs to treat the condition.
Key Benefits
The first animal model for elucidating the underlying causes of galactosemia in infants.
Animals with galactosemia causing genetic knockout exhibit similar disease phenotypes and complications...
Published: 7/28/2023
Contributor(s): Judith Fridovich-Keil
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Liquid-hydrogel Hybrid Microfluidic Device
Application
Measurement device for detecting of single-cell dynamics under environment perturbations or drug treatment.
Key Benefits
Fast determination of drug sensitivity.
Long-term continuous cell-fate tracking.
Time-lapse analysis of cell proliferation.
Cell community analysis: intra-species interactions, inter-species interactions.
Market...
Published: 9/26/2023
Contributor(s): Kyle Allison, Xin Fang, Devina Puri
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Methods for Enhancing MSC Therapeutic Potential for Treatment of Osteoarthritis by Measuring and Targeting Intracellular Pathways
Application
Highly transformative new strategy to enhance mesenchymal stromal cell consistency and efficacy for taking MSC therapies to clinical stage.
Key Benefits
Currently there is no method to determine if an MSC donor line will be therapeutically effective.
Provides a point of use assay in the clinical setting which can determine MSC efficacy...
Published: 9/26/2023
Contributor(s): Nick Willett, Levi Wood, Jay McKinney
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Imaging and Tracking mRNA in Live Mammalian Cells via Fluorogenic Photoaffinity Labeling
Application
An improved method for labeling and imagine RNA in live cells.
Key Benefits
Low background signal.
Covalent binding suitable for time-resolved investigations.
Photoactivatable for temporal control.
Market Summary
Ribonucleic acid (RNA) molecules are synthesized in cells through highly regulated biogenesis pathways, and when these...
Published: 9/15/2023
Contributor(s): Tewoderos Ayele, Jennifer Heemstra
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A Method of Using Responsive Micro and Sub-micro Scale Polymer Particles for Mechanical Manipulation of Molecules
Application
A method to study the mechanical/controlled unfolding of biomolecules using a polymer force clamp (PFC).
Key Benefits
Particles can be immobilized onto virtually any type of support.
Particles can also be functionalized with a variety of small-molecule, peptide and protein ligands.
Ability to have multiple PFC’s measuring associated...
Published: 7/28/2023
Contributor(s): Hanquan Su, Khalid Salaita
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BG505 SOSIP Vaccine Elicited Neutralizing Monoclonal Antibodies for HIV
Application
ELISA
Western Blot
Immunohistochemistry
Specficity
HIV-1 BG505 Env protein (clone name: YRK01, YRK02).
Subtype
Monoclonal antibody.
Immunogen
HIV-1 BG505 SOSIP Env trimer.
Technical Summary
HIV-1 envelope glycoprotein (Env) is a membrane protein complex involved in receptor recognition and viral fusion with CD4+ T cells...
Published: 7/28/2023
Contributor(s): Cynthia Derdeyn, Tysheena Charles
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HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform
Application
High Throughput Screening for identifying effective immuno-modulators.
Key Benefits
HT screening platform replicating complex immune medicated response to facilitate discovery of small molecule immunomodulatory agents.
Simplicity and dual readouts of the design enable the screening of large chemical libraries to identify compounds...
Published: 7/28/2023
Contributor(s): Xiulei Mo, Haian Fu
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Tyrosinase Viral Vectors for the Generation of Rodents Exhibiting Time -Dependent Production and Intracellular Accumulation of Human-Like Neuromelanin
Application
Improved study of neurodegenerative diseases on mice.
Key Benefits
Ability to study neuromelanin’s association with neurodegenerative diseases with mice.
Researchers can analyze overexpression of tyrosinase on specific cell types.
Market Summary
Neurodegenerative diseases such as Alzheimer’s and Parkinson’s...
Published: 7/28/2023
Contributor(s): David Weinshenker, Alexa Iannitelli
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