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Optimizing the Engineering of CAR-T Cells
Application A method for selecting distinct T cell populations in order to generate more effective CAR-T cells. Key Benefits The proposed invention focuses on selecting the optimal “starting material” for the engineering CAR-T cells. This selection method can be utilized for the development of any and all CAR-T therapies, not limited...
Published: 4/11/2024       Contributor(s): Byron Au-Yeung
A 3D In Vitro Model of the Human Locus Coeruleus
Application A brain organoid model for the human locus coeruleus to study its function and dysfunction in neurological diseases. Key Benefits Locus coeruleus region-specific neural organoid model for studying this deep region of the human brain. The organoid synthesizes norepinephrine, allowing for study of diseases related to these neurotransmitters. The...
Published: 4/8/2024       Contributor(s): Fikri Birey, David Weinshenker
Questionnaires for Assessing the Effect of Visual Impairment on Quality of Life and Function in Children
Application A standardized series of questions for the assessment of vision related quality of life and visual function in children and adolescents. Key Benefits Provides age-appropriate questions for children from ages 8-18 as an improvement to using currently available assessments geared toward adults. Allows the subjective assessment of the...
Published: 4/23/2024       Contributor(s): Sheila Angeles-Han
Mouse Model for Specific Proteomic Labeling
Application Proteomic labeling (labeling of proteins). Key Benefits Method can be used to express TurboID in any cell type. The mouse line can be crossed with any existing Cre line and can be extended to any organ/tissue system. Detection of labeled biomarkers can be identified in biofluids as biomarkers of cell specific disease mechanisms. Can...
Published: 12/7/2023       Contributor(s): Srikant Rangaraju, Nicholas Seyfried, Sruti Rayaprolu
Human Brain Proteins with Evidence Consistent with Causality of Alzheimer’s and Depression
Application Research and therapeutic targets for Alzheimer’s disease, depression, and other neurological conditions mediated by protein expression in the brain. Key Benefits These findings can be utilized as a research tool to better understand the genetic basis of Alzheimer’s disease. Can also be utilized to develop therapeutics for...
Published: 4/23/2024       Contributor(s): Aliza Wingo, Thomas Wingo, Yue Liu, Allan Levey, Nicholas Seyfried, Duc Duong
Pig Lentiviral-Induced Spinal Cord Glioblastoma
Application Porcine model of spinal cord glioblastoma for the development and testing of pre-clinical therapeutic for spinal cord tumors. Key Benefits Novel lentiviral gene transfer offers a viable pathway to modeling glioblastoma in higher order species. The existing model is the first reproducible immunocompetent large animal model of spinal...
Published: 4/23/2024       Contributor(s): Muhibullah (Mohib) Tora, Pavlos Texakalidis, Thais Buchman, Nicholas Boulis
Tension-activated Cell Tagging (TaCT)
Application A tool that measures cellular mechanical forces using flow cytometry. Key Benefits A fluorescently labeled approach based on the magnitude of molecular forces transmitted through cell adhesion receptors for evaluating mechanical forces in cells. A prototype has been developed showing proof -of-concept via the ability to determine mechanical...
Published: 5/21/2024       Contributor(s): Rong Ma, Khalid Salaita
Machine Learning Diagnostic for Automated Identification and Classification of Bone Marrow Cells
Application Machine learning tool to aid in the diagnosis of hematologic disorders of bone marrow. Key Benefits Automated machine learning-based approach for performing bone marrow differential counts that accounts for all viable cells on the smear. Data generated by a prototype shows the system is fast and demonstrates precision compared to manual...
Published: 11/27/2023       Contributor(s): Lee Cooper, David Gutman, David Jaye, Ahmed Aljudi, Ramraj Chandradevan
Improved Clinical Diagnostic Method for SARS-CoV-2 Infection
Application A more reliable and accurate method for diagnosing SARS-CoV-2 infection based on the biochemical interactions between the spike trimer and ACE-2 protein. Key Benefits A fast, affordable, and easy-to-use SARS-Cov-2 diagnostic test for use in clinical settings. Market Summary SARS-CoV-2 has evolved significantly since the onset of...
Published: 11/27/2023       Contributor(s): John Roback, Andrew Neish, Narayanaiah Cheedarla, Hans Verkerke, Huixia Wu, William Osick, Kaleb Mclendon, Sindhu Potlapalli
Whole-Animal Genetic Model to Mimic Aspects of the Patient Phenotype of Classic Galactosemia
­ Application An animal model for studying the underlying causes of galactosemia and screening for novel drugs to treat the condition. Key Benefits The first animal model for elucidating the underlying causes of galactosemia in infants. Animals with galactosemia causing genetic knockout exhibit similar disease phenotypes and complications...
Published: 7/28/2023       Contributor(s): Judith Fridovich-Keil
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