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Liposome Encapsulated Tyrosine Kinase Inhibitors to Treat Leukemia
Application Lipid encapsulation of MRX-2843 for the treatment of leukemia. Key Benefits Encapsulation of a tyrosine kinase inhibitor called MRX-2843 within a liposome improves its performance in an animal model of acute lymphoblastic leukemia. Systemic delivery of this therapeutic requires a lower dose and less frequent administration than oral...
Published: 5/21/2024       Contributor(s): Erik Dreaden, James Kelvin, Deborah DeRyckere, Douglas Graham, Juhi Jain
Using Hetero-multivalent DNA-functionalized Materials to Detect Genetic Mutations
Application Improving diagnostic accuracy using hetero-multivalent DNA-functionalized materials for disease targets containing one or more genetic mutations. Key Benefits Tunable oligos increase specificity and cooperative binding to the disease target of interest. Distinguishes between cis- and trans mutations. Identifies different strains of...
Published: 5/21/2024       Contributor(s): Brendan Deal, Khalid Salaita, Rong Ma, James Kindt
Implanted Passive Pressure Sensor Interrogated with (Ultra)-Sound (iPPSIS)
Application Easy-to-use, short and long-term, minimally invasive, MR-safe approach for directly measuring the variation of intracranial pressure. Key Benefits A minimally invasive device that is compatible with MRI imaging for quantitatively measuring intracranial pressure. A prototype has been developed showing the ability to measure shunt pressure...
Published: 5/21/2024       Contributor(s): David Myers, Nicholas Au Yong, Brooks Lindsey, Cecilia Alessandra Luna, Saeyoung (Sunny) Kim, Bowen Jing
Reagents and Hardware for RNA Storage at Ambient Temperatures
Application Simple and economical method for isolating and storing RNA from biological samples at room temperatures. Key Benefits Alternative, low-cost extraction method suitable for extracting RNA from biological samples for molecular analysis and disease diagnosis. Eliminates the need for expensive proprietary materials, hazardous chemicals,...
Published: 5/21/2024       Contributor(s): Jesse Waggoner, David Myers, Sarah Hernandez, Dhruv Miglani
Improving CAR T cell efficacy with Cytokine-Loaded Microparticles
Application Novel reagents for manufacturing of CAR T cells with improved characteristics. Key Benefits A multi-cytokine backpack particle that can be used during manufacturing process of CAR T treatments to improve their phenotype and efficacy. Preliminary data show the method can transduce primary healthy and patient T cells and promote CAR...
Published: 1/10/2024       Contributor(s): Sarwish Rafiq, Erik Dreaden, A K M Nawshad Hossian, Biaggio Uricoli
Chameleon-Inspired Strain-Accommodating Smart Skin
Application A flexible smart skin that changes its color in response to heat or sunlight. Key Benefits Strain-accommodating. Thermal and photothermal responsive. Light responsive. Highly stretchable. Market Summary Hydrogels are water-insoluble, three-dimensional networks of polymer chains capable of holding large amounts of water. They are...
Published: 12/7/2023       Contributor(s): Khalid Salaita, Yixiao Dong
Functionalized Collagen Biochips with Core-Shell Structures and Collagen-Mimetic Peptide Nanotubes
Application Synthetic collagen-based biomaterials for therapeutic delivery or drug testing. Key Benefits Synthetic collagen substitute. Capable of formulating into various structures. Free of animal-based contaminants. Able to be spatially patterned. Market Summary Organ failure and tissue defects affect millions of Americans, resulting in...
Published: 5/21/2024       Contributor(s): Vincent Conticello, Andrea Merg, Gavin Touponse
A Method of Using Responsive Micro and Sub-micro Scale Polymer Particles for Mechanical Manipulation of Molecules
Application A method to study the mechanical/controlled unfolding of biomolecules using a polymer force clamp (PFC). Key Benefits Particles can be immobilized onto virtually any type of support. Particles can also be functionalized with a variety of small-molecule, peptide and protein ligands. Ability to have multiple PFC’s measuring associated...
Published: 4/23/2024       Contributor(s): Hanquan Su, Khalid Salaita
Serological Test for SARS-CoV-2
­ Application Clinical assay for detecting SARS-CoV-2 neutralizing antibodies. Key Benefits Highly specific and sensitive. Fewer false positives than commercially available tests. Market Summary SARS-CoV-2 is currently causing a devastating pandemic and there is a pressing need to understand the dynamics, specificity, and neutralizing...
Published: 12/20/2023       Contributor(s): Rafi Ahmed, Mehul Suthar, John Roback, Jens Wrammert, Robert Kauffman
tPAINT to Measure Molecular Forces in Live Cells
Application DNA-based probes to measure the nanoscale distribution of piconewton molecular forces in live cells. Key Benefits Provides maps of integrin tension with up to ˜25 nm resolution and piconewton force sensitivity for live-cell imaging. The tPAINT can be performed on a commercial TIRF microscope. Market Summary Emory inventors...
Published: 12/7/2023       Contributor(s): Joshua Brockman, Hanquan Su, Khalid Salaita
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