Technology Listings


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tPAINT to Measure Molecular Forces in Live Cells
Application DNA-based probes to measure the nanoscale distribution of piconewton molecular forces in live cells. Key Benefits Provides maps of integrin tension with up to ˜25 nm resolution and piconewton force sensitivity for live-cell imaging. The tPAINT can be performed on a commercial TIRF microscope. Market Summary Emory inventors...
Published: 11/17/2020       Contributor(s): Joshua Brockman, Hanquan Su, Khalid Salaita
Engineering Tighter Binding Spherical Nucleic Acids
Application Method to enhance the affinity of spherical nucleic acids for their targets. Key Benefits Facile method for molecular printing on surface of NP. Massive improvement of SNA’s binding affinity to the target can provide strategies in applications for therapeutics and diagnostics. May maximize DNA density on the NP surface. Market...
Published: 11/2/2020       Contributor(s): Brendan Deal, Khalid Salaita
Targeted Theranostic NanoToxin for Treating Metastatic and Drug-resistant Tumors
Application Magnetic theranostic nano-toxin for imaging and drug delivery applications in cancer therapy. Key Benefits Induces tumor cell death via a different biological mechanism, compared to current chemotherapeutics, to overcome drug resistance mechanisms in tumor cells. Delivers high levels of therapeutic agents into metastatic tumors, while...
Published: 11/2/2020       Contributor(s): Lily Yang, Xiangxue Guo, Hui Mao, Wei Chen
Platform for Transducing Target Cells with a Viral Vector
Application System for quickly and efficiently obtaining therapeutic levels of transduction. Key Benefits Uses less viral vector to achieve high gene transfer. Shortens transduction time. Produces clinically relevant gene modified cell numbers. Market Summary Information relay at the molecular level, such as the transcription of RNA into proteins,...
Published: 1/23/2020       Contributor(s): Reginald Tran, Wilbur Lam, Christopher Doering, H. (Harold) Trent Spencer
Real-time, Particle-Tracking and Control Software for Electromagnetic Tweezers
Application Software to control electromagnetic tweezers and to track tethered particles in real-time in 3D. Key Benefits Electromagnets offer improved temporal response without mechanical vibration. 3D particle tracking utilizing a continuous LUT built from multidimensional spline fits of discrete data improves accuracy and provides precision...
Published: 1/14/2020       Contributor(s): Daniel Kovari, David Dunlap, Laura Finzi
Targeted Anti-Cancer Nanoparticle Therapy
Application A drug-carrying nanoparticle that selectively targets cancer cells. Key Benefits Incorporates an already proven anti-cancer therapeutic. Increases deliverability. Targets cancer cells. Market Summary Tris DBA palladium has been shown to have anti-cancer activity against melanoma and pancreatic cancer. However, Tris DBA has not...
Published: 9/9/2019       Contributor(s): Jack Arbiser, Lily Yang
DNAzyme Nanoparticles for the Cleavage of RNA
Application Site-selective RNA splicing nanozyme for cleaving and ligating RNA. Key Benefits Can cleave virtually any RNA stem loop. Removes a 19 nucleotide segment from a 67 nucleotide RNA loop with up to 66% efficiency. Technical Summary Modulating RNA can be useful for studying RNA biology, gene knockdown, and regulating RNA splicing. Scientists...
Published: 9/5/2019       Contributor(s): Jessica Petree, Kevin Yehl, Khalid Salaita
Multi-Step DNA “Domino” Nanoarray
Application DNA nanoarray for constructing nanostructures and molecular devices to detect and translate interactions and changes. Key Benefits Transfers information via DNAs shape transformation. Allows high precision and complexity of transformation. Market Summary Information relay at the molecular level, such as the transcription of RNA...
Published: 8/6/2019       Contributor(s): Yonggang Ke, Chengde Mao, Jie Song, Zhe Li, Pengfei Wang, Travis Meyer
GeneRegs: Nanoparticles for Treatment of Severe Asthma
Application Gold nanoparticles coated with enzyme which specifically targets and degrades asthma-associated inflammation molecules. Key Benefits Specifically suppresses asthma associated inflammation. Easy self-administration by inhalation. Market Summary Asthma is defined as a chronic inflammatory lung disease with significant worldwide morbidity....
Published: 12/4/2017       Contributor(s): Khalid Salaita, Cherry Wongtrakool, Kornelia Galior
Micron-Sized Drug Vehicle for Unregulated Blood Clotting
Application Fibrinogen-coated micron-sized drug vehicles for targeted treatment of unregulated blood clotting. Key Benefits Facilitates targeted release of drugs specifically for blood clotting disorders. Drug delivery vehicle can be used with newly discovered or known therapeutics on the market. Site specific biological mechanism may help increase...
Published: 2/20/2017       Contributor(s): Caroline Hansen, Yumiko Sakurai, Wilbur Lam, Andrew Lyon
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