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Chameleon-Inspired Strain-Accommodating Smart Skin
­ Application A flexible smart skin that changes its color in response to heat or sunlight. Key Benefits Strain-accommodating. Thermal and photothermal responsive. Light responsive. Highly stretchable. Market Summary Hydrogels are water-insoluble, three-dimensional networks of polymer chains capable of holding large amounts of water....
Published: 12/20/2022       Contributor(s): Khalid Salaita, Yixiao Dong
Functionalized Collagen Biochips with Core-Shell Structures and Collagen-Mimetic Peptide Nanotubes
Application Synthetic collagen-based biomaterials for therapeutic delivery or drug testing. Key Benefits Synthetic collagen substitute. Capable of formulating into various structures. Free of animal-based contaminants. Able to be spatially patterned. Market Summary Organ failure and tissue defects affect millions of Americans, resulting in...
Published: 12/20/2022       Contributor(s): Vincent Conticello, Andrea Merg, Gavin Touponse
A Method of Using Responsive Micro and Sub-micro Scale Polymer Particles for Mechanical Manipulation of Molecules
­ Application A method to study the mechanical/controlled unfolding of biomolecules using a polymer force clamp (PFC). Key Benefits Particles can be immobilized onto virtually any type of support. Particles can also be functionalized with a variety of small-molecule, peptide and protein ligands. Ability to have multiple PFC’s measuring...
Published: 12/6/2022       Contributor(s): Hanquan Su, Khalid Salaita
Serological Test for SARS-CoV-2
­ Application Clinical assay for detecting SARS-CoV-2 neutralizing antibodies. Key Benefits Highly specific and sensitive. Fewer false positives than commercially available tests. Market Summary SARS-CoV-2 is currently causing a devastating pandemic and there is a pressing need to understand the dynamics, specificity, and neutralizing...
Published: 1/10/2023       Contributor(s): Rafi Ahmed, Mehul Suthar, John Roback, Jens Wrammert, Robert Kauffman
tPAINT to Measure Molecular Forces in Live Cells
Application DNA-based probes to measure the nanoscale distribution of piconewton molecular forces in live cells. Key Benefits Provides maps of integrin tension with up to ˜25 nm resolution and piconewton force sensitivity for live-cell imaging. The tPAINT can be performed on a commercial TIRF microscope. Market Summary Emory inventors...
Published: 8/9/2022       Contributor(s): Joshua Brockman, Hanquan Su, Khalid Salaita
Engineering Tighter Binding Spherical Nucleic Acids
Application Method to enhance the affinity of spherical nucleic acids for their targets. Key Benefits Facile method for molecular printing on surface of NP. Massive improvement of SNA’s binding affinity to the target can provide strategies in applications for therapeutics and diagnostics. May maximize DNA density on the NP surface. Market...
Published: 12/20/2022       Contributor(s): Brendan Deal, Khalid Salaita
Targeted Theranostic NanoToxin for Treating Metastatic and Drug-resistant Tumors
Application Magnetic theranostic nano-toxin for imaging and drug delivery applications in cancer therapy. Key Benefits Induces tumor cell death via a different biological mechanism, compared to current chemotherapeutics, to overcome drug resistance mechanisms in tumor cells. Delivers high levels of therapeutic agents into metastatic tumors, while...
Published: 1/10/2023       Contributor(s): Lily Yang, Xiangxue Guo, Hui Mao, Wei Chen
Platform for Transducing Target Cells with a Viral Vector
Application System for quickly and efficiently obtaining therapeutic levels of transduction. Key Benefits Uses less viral vector to achieve high gene transfer. Shortens transduction time. Produces clinically relevant gene modified cell numbers. Market Summary Information relay at the molecular level, such as the transcription of RNA into proteins,...
Published: 12/6/2022       Contributor(s): Reginald Tran, Wilbur Lam, Christopher Doering, H. (Harold) Trent Spencer
Real-time, Particle-Tracking and Control Software for Electromagnetic Tweezers
Application Software to control electromagnetic tweezers and to track tethered particles in real-time in 3D. Key Benefits Electromagnets offer improved temporal response without mechanical vibration. 3D particle tracking utilizing a continuous LUT built from multidimensional spline fits of discrete data improves accuracy and provides precision...
Published: 9/29/2022       Contributor(s): Daniel Kovari, David Dunlap, Laura Finzi
Targeted Anti-Cancer Nanoparticle Therapy
Application A drug-carrying nanoparticle that selectively targets cancer cells. Key Benefits Incorporates an already proven anti-cancer therapeutic. Increases deliverability. Targets cancer cells. Market Summary Tris DBA palladium has been shown to have anti-cancer activity against melanoma and pancreatic cancer. However, Tris DBA has not...
Published: 1/10/2023       Contributor(s): Jack Arbiser, Lily Yang
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