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Improving CAR T cell efficacy through with Cytokine-Loaded Microparticles
Application
Novel reagents for manufacturing of CAR T cells with improved characteristics.
Key Benefits
A multi-cytokine backpack particle that can be used during manufacturing process of CAR T treatments to improve their phenotype and efficacy.
Preliminary data show the method can transduce primary healthy and patient T cells and promote CAR...
Published: 7/28/2023
Contributor(s): Sarwish Rafiq, Erik Dreaden, A K M Nawshad Hossian, Biaggio Uricoli
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Chameleon-Inspired Strain-Accommodating Smart Skin
Application
A flexible smart skin that changes its color in response to heat or sunlight.
Key Benefits
Strain-accommodating.
Thermal and photothermal responsive.
Light responsive.
Highly stretchable.
Market Summary
Hydrogels are water-insoluble, three-dimensional networks of polymer chains capable of holding large amounts of water. They are...
Published: 7/28/2023
Contributor(s): Khalid Salaita, Yixiao Dong
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Functionalized Collagen Biochips with Core-Shell Structures and Collagen-Mimetic Peptide Nanotubes
Application
Synthetic collagen-based biomaterials for therapeutic delivery or drug testing.
Key Benefits
Synthetic collagen substitute.
Capable of formulating into various structures.
Free of animal-based contaminants.
Able to be spatially patterned.
Market Summary
Organ failure and tissue defects affect millions of Americans, resulting in...
Published: 7/28/2023
Contributor(s): Vincent Conticello, Andrea Merg, Gavin Touponse
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A Method of Using Responsive Micro and Sub-micro Scale Polymer Particles for Mechanical Manipulation of Molecules
Application
A method to study the mechanical/controlled unfolding of biomolecules using a polymer force clamp (PFC).
Key Benefits
Particles can be immobilized onto virtually any type of support.
Particles can also be functionalized with a variety of small-molecule, peptide and protein ligands.
Ability to have multiple PFC’s measuring associated...
Published: 7/28/2023
Contributor(s): Hanquan Su, Khalid Salaita
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Serological Test for SARS-CoV-2
Application
Clinical assay for detecting SARS-CoV-2 neutralizing antibodies.
Key Benefits
Highly specific and sensitive.
Fewer false positives than commercially available tests.
Market Summary
SARS-CoV-2 is currently causing a devastating pandemic and there is a pressing need to understand the dynamics, specificity, and neutralizing...
Published: 9/26/2023
Contributor(s): Rafi Ahmed, Mehul Suthar, John Roback, Jens Wrammert, Robert Kauffman
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tPAINT to Measure Molecular Forces in Live Cells
Application
DNA-based probes to measure the nanoscale distribution of piconewton molecular forces in live cells.
Key Benefits
Provides maps of integrin tension with up to ˜25 nm resolution and piconewton force sensitivity for live-cell imaging.
The tPAINT can be performed on a commercial TIRF microscope.
Market Summary
Emory inventors...
Published: 7/28/2023
Contributor(s): Joshua Brockman, Hanquan Su, Khalid Salaita
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Engineering Tighter Binding Spherical Nucleic Acids
Application
Method to enhance the affinity of spherical nucleic acids for their targets.
Key Benefits
Facile method for molecular printing on surface of NP.
Massive improvement of SNA’s binding affinity to the target can provide strategies in applications for therapeutics and diagnostics.
May maximize DNA density on the NP surface.
Market...
Published: 9/15/2023
Contributor(s): Brendan Deal, Khalid Salaita
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Targeted Theranostic NanoToxin for Treating Metastatic and Drug-resistant Tumors
Application
Magnetic theranostic nano-toxin for imaging and drug delivery applications in cancer therapy.
Key Benefits
Induces tumor cell death via a different biological mechanism, compared to current chemotherapeutics, to overcome drug resistance mechanisms in tumor cells.
Delivers high levels of therapeutic agents into metastatic tumors, while...
Published: 9/6/2023
Contributor(s): Lily Yang, Xiangxue Guo, Hui Mao, Wei Chen
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Platform for Transducing Target Cells with a Viral Vector
Application
System for quickly and efficiently obtaining therapeutic levels of transduction.
Key Benefits
Uses less viral vector to achieve high gene transfer.
Shortens transduction time.
Produces clinically relevant gene modified cell numbers.
Market Summary
Information relay at the molecular level, such as the transcription of RNA into proteins,...
Published: 7/28/2023
Contributor(s): Reginald Tran, Wilbur Lam, Christopher Doering, H. (Harold) Trent Spencer
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Real-time, Particle-Tracking and Control Software for Electromagnetic Tweezers
Application
Software to control electromagnetic tweezers and to track tethered particles in real-time in 3D.
Key Benefits
Electromagnets offer improved temporal response without mechanical vibration.
3D particle tracking utilizing a continuous LUT built from multidimensional spline fits of discrete data improves accuracy and provides precision...
Published: 7/28/2023
Contributor(s): Daniel Kovari, David Dunlap, Laura Finzi
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