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SARS-CoV-2 Neutralizing Human Monoclonal Antibodies
­ Application Monoclonal antibodies to SARS-CoV2 for use in COVID-19 diagnostics and therapeutics. Key Benefits Demonstrably neutralizing, important for therapeutic mAbs. Most bind both RBG and stalk portion of spike protein, useful in case SARS-CoV2 strains develop variation in RBD. Market Summary Coronavirus (COVID-19) is an infectious...
Published: 7/6/2022       Contributor(s): Jens Wrammert, Carl Davis, Mehul Suthar, Robert Kauffman
A Predictive Marker and Treatment to Sensitize Multiple Myeloma Patients to Venetoclax (ABT-199)
Application A marker that predicts Venetoclax (ABT-199) sensitivity that can also be targeted with a drug to help multiple myeloma patients. Key Benefits Marker that predicts if venetoclax will be an effective treatment in multiple myeloma patients. A drug that targets venetoclax resistant multiple myeloma cells to improve treatment in patients. Market...
Published: 2/23/2022       Contributor(s): Malathy (mala) Shanmugam, Richa Bajpai
Serological Test for SARS-CoV-2
­ Application Clinical assay for detecting SARS-CoV-2 neutralizing antibodies. Key Benefits Highly specific and sensitive. Fewer false positives than commercially available tests. Market Summary SARS-CoV-2 is currently causing a devastating pandemic and there is a pressing need to understand the dynamics, specificity, and neutralizing...
Published: 1/24/2022       Contributor(s): Rafi Ahmed, Mehul Suthar, John Roback, Jens Wrammert, Robert Kauffman
A New Method to Detect and Tackle Antibiotic Heteroresistance
­ Application A method to detect heteroresistance to antibiotics in bacteria. Key Benefits Significantly faster than commercially available options. Aside from the interferometer itself, no specialized reagents are required. Inexpensive to use. Market Summary Antibiotic resistance is a significant threat to public health. Rapid and sensitive...
Published: 1/10/2022       Contributor(s): David Weiss, Peter Yunker, David Hufnagel, Arben (Ben) Kalziqi
Software to Correct 4D CT Scan Image Distortion
Application A software that employs unsupervised deep learning to correct 4D CT scan image distortion due to respiratory motions. Key Benefits Allows the generation of highly precise, motion-corrected 4D CT images Market Summary CT scans usually allow radiation oncologists to contour a tumor’s area and position. However, abdominal motions...
Published: 1/6/2022       Contributor(s): Yang Lei, Tian Liu, Xiaofeng Yang, Yabo Fu
Low Dose PET/MRI and PET/CT Imaging
Application A deep-learning based method for generating diagnostic-quality PET images from lower quality images to reduce scanning time and radiation exposure Key Benefits Generates a high quality synthetic high-count PET image from low-count PET image or CT scan image Reduces radiation exposure to patient Reduces scanning time Market Summary Positron...
Published: 1/6/2022       Contributor(s): Xiaofeng Yang, Yang Lei, Hui Mao, Tian Liu, Jonathon Nye, Xue (Xueyuan) Dong
Biocompatible Nanoreporter for Measuring Fluidic Shear Stress
­ Application A research tool for quantifying fluidic shear stress in vitro and in vivo. Key Benefits Directly measures sub-cellular shear stress from 0.5 dynes/cm2 to 100 dynes/cm2. Can target specific ligands of interest. Compatible with existing fluorescent approaches. Flexible design allows for multiple modifications for a variety of...
Published: 12/2/2021       Contributor(s): David Myers, Yonggang Ke, Victor Pan, Shreyas Dahotre, Gabriel (Gabe) Kwong
Software Capable of Generating Different Angles Based on Singular MRI
Application A software for multimodal MR (magnetic resonance) image-to-image translations using only a single MRI (magnetic resonance image) modality. Key Benefits Can generate any arbitrary MRI from any other arbitrary MRI. Potential clinical tool for fast multimodal MR image generation with a single scan. Reduce scan time, increase patient...
Published: 12/2/2021       Contributor(s): Xiaofeng Yang, Yang Lei, Hui Mao, Tian Liu
Predicting Treatment Response in Patients with Spinal Muscular Atrophy (SMA)
Application Prognostic model predicts treatment response to nusinersen (Spinraza®) in patients with spinal muscular atrophy. Key Benefits A prediction model using baseline CHOP-INTEND, IL-8, fractalkine, and MCP-1 accurately predicts CHOP-INTEND outcomes in children treated with nusinersen The model can also be incorporated into future therapeutic...
Published: 7/13/2021       Contributor(s): William Hu, Sumit Verma
Vision Test for Non-Verbal Children
Application Vision testing for non-verbal children, the hearing impaired, and non English-speaking population. Key Benefits Simplifies vision testing for non-verbal children. Does not require any verbal communication to be used effectively. Technical Summary While traditional eye charts are often effective, they rely on verbal communication...
Published: 2/3/2021       Contributor(s): Amy Hutchinson, Caroline Cromelin, Cindy Harrington
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