Technology Listings


Repurposed Kinase Inhibitor for Treatment of Multidrug Resistant Tuberculosis

Application

Protein tyrosine kinase inhibitor (imatinib) used as a treatment to prevent multiple drug-resistant tuberculosis lethality and latent reactivation.

Key Benefits
  • Effective against drug resistant strains of tuberculosis.
  • May be used in combination with current first-line treatments of TB.
Market Summary

Tuberculosis (TB) is a chronic infectious disease which primarily affects lungs and often co-infects individuals with HIV. Although curable, TB still continues to be a global health problem as one of the most common cause of death from an infectious disease. According to the World Health Organization, about one third of the world’s population is infected with latent TB and at risk for developing active disease, with higher prevalence in lower and middle income countries. Further, multidrug-resistant varieties of Tuberculosis (MDR-TB) pose an increasing threat to overall control of the epidemic by rendering majority of first line of drugs ineffective. Additional complexities of second line of drugs include adverse side effects, longer treatment period, and increased cost.

Technical Summary

Mycobacterium tuberculosis post-infection survives in the human body by attacking and escaping the innate immune system. MDR-TB has the ability to use intracellular protein kinases for entry and survival in macrophages. Emory inventors have repurposed a protein tyrosine kinase inhibitor (imatinib), currently used in cancer therapy, for the treatment of MDR-TB. The inhibitor can be used alone or in combination with other antibiotics. The preclinical in vivo studies indicate that mice treated with imatinib alone, or in combination with an antibiotic, have reduced bacterial load in macrophages and granulomatous lesion in liver within 6 hours of administration. They have further shown imatinib to be effective against first line (rifampicin) resistant strains. In vivo data suggests that imatinib is efficacious alone and in combination with antibiotics to treat MDR-TB. This treatment may also have applications for patients diagnosed with HIV.

Development Stage

In vivo data available demonstrating the efficacy of treating MDR-TB with imatinib by itself and in combination with an antibiotic.

Publication: Napier, RJ et al. Cell Host Microbe. 2011; 10(5): 475 – 485

Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Nationalized PCT - United States United States 15/760,978 3/16/2018     Pending
Tech ID: 16002
Published: 6/20/2017
Category
Drug Discovery
Therapeutics

Contact
Justin Burns
Assistant Director, Licensing
Emory University
404-727-4968
justin.burns@emory.edu

Inventor(s)
Daniel Kalman

Keywords
Microbiology/Infectious Diseases
Repurposed Drug