Technology Listings


Protein Phosphatase 2A Demethylase Protein and DNA Sequences

Applications

Can be used in assays to search for drugs that modulate protein phosphatase 2A (PP2A) methylesterase activity or to make recombinant protein to be used in assays. Such derivatives have potential application as anti-cancer and Alzheimer's treatment drugs.

Technical Summary

Protein phosphatase 2A (PP2A) is involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. Therefore, it is not surprising that PP2A is highly regulated. This invention describes the cloning of a modulating enzyme for human PP2A, named Protein Phosphatase Methylesterase-1 (PME-1). It provides the nucleotide sequences encoding PME-1 and the deduced amino acid sequence. In addition, this invention provides methods for producing recombinant PME-1 polypeptide, which can then be used for in vitro assays to identify inhibitors or activators of PME-1 activity. Such inhibitor or activator drugs are likely to modulate cell cycle, apoptosis, and tau hyperphosphorylation and may be useful in treating diseases such as cancer and Alzheimer's Disease.

Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Utility(parent) United States 09/293,322 6,232,110 4/16/1999 5/15/2001 4/16/2019
Divisional United States 09/839,497 6,528,295 4/16/1999 3/4/2003 4/16/2019
Tech ID: 97053
Published: 2/24/2009
Category
Research Tools

Contact
Rajsekhar Guddneppanavar
Licensing Associate
Emory University
RGUDDNE@emory.edu

Inventor(s)
David Pallas
Xianxing Du

Keywords
Assay
Enzyme/Protein
Microbiology/Infectious Diseases
Neuroscience/Pain
Oncology