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Combination Therapy for Increasing Venetoclax Sensitivity in Multiple Myeloma
Application Marker and co-therapy that inhibits succinate dehydrogenase to increase patient response to venetoclax. Key Benefits Co-therapy increases MM sensitivity to venetoclax treatment. Identifies patients who will respond to venetoclax therapy. Market Summary Multiple Myeloma (MM) is a cancer of plasma cells responsible for making ant...
Published: 6/18/2019       Inventor(s): Malathy (mala) Shanmugam, Richa Bajpai
Peptide Therapeutic for Acute Respiratory Distress Syndrome
ApplicationAnti-claudin 5 peptide to improve lung barrier function for the treatment of alcohol-induced acute respiratory distress syndrome (ARDS).Key BenefitsNew target for treating ARDS.Small inhibitory peptide to specifically target claudin-5.Market SummaryApproximately 200,000 cases of acute respiratory distress syndrome (ARDS) are diagnosed ea...
Published: 5/13/2019       Inventor(s): Michael Koval, Barbara Schlingmann-Molina
Therapeutic Target for Hepatic Fibrosis
ApplicationPeriostin as a therapeutic target for liver disease.Key BenefitsNew therapeutic target for preventing fibrosis from entering cirrhosis stage.Therapeutic target may be used for identifying new therapy for fibrosis.Market SummaryCirrhosis is a condition in which the liver is unable to function normally due to chronic, or long lasting, inju...
Published: 3/23/2018       Inventor(s): Frank Anania, Pradeep Kumar
Targeting Peptides for Myocarditis
ApplicationTargeting peptide molecule for image-based diagnosis of myocarditis.Key BenefitsEnables noninvasive diagnosis of myocarditis.Targets and binds to biomarker of myocarditis.Market SummaryMyocarditis is an inflammation of the heart muscle (myocardium). Myocarditis can affect your heart muscle and your heart's electrical system, reducing the...
Published: 2/7/2018       Inventor(s): Michael Davis, Mario Martinez
Therapeutic Target and Methods to Treat Sepsis
ApplicationThe identification of the coinhibitory receptor 2B4 and its ligand CD48 as targets for the treatment of sepsis.Key BenefitsA target for the prevention of mortality during sepsis. Blocking the 2B4 coinhibitory receptor or its ligand, CD48, may reduce mortality during sepsis in humans. Market SummaryThere are approximately 750,000 cases of...
Published: 6/24/2016       Inventor(s): Mandy Ford, Craig Coopersmith
Nox cDNA and Enzymes for Drug Discovery, for Diagnostics, and as Research Tools
Application Target for drug discovery, gene therapy and to create a diagnostic tool relevant to conditions involving inappropriate cell proliferation. Technical Summary Reactive oxygen species (ROS) include superoxide and hydrogen peroxide. ROS are increasingly being recognized as playing a central role in diverse physiologic and pathologic proc...
Published: 3/26/2009       Inventor(s): David Lambeth, Guang Cheng
Mitogenic Regulators and Targets for Drug Development
Applications Target for drug development for diseases involving abnormal proliferation of cells, including psoriasis (hyperproliferation of skin cells) and benign prostatic hypertrophy. Technical Summary Reactive oxygen intermediates (ROI) are generated during an oxidative process that occurs in many cell types. The result of generating reactive...
Published: 3/26/2009       Inventor(s): David Lambeth, Bernard Lassegue, Kathy Griendling, Rebecca Arnold, Guang Cheng
Use of High Affinity Mutants of 4E mRNA Isolation/Purification
Application Isolation and purification of mRNA; identification of drug targets. Technical Summary Isolation mRNA is the first step to sequencing expression sequence tags, which are the foundation of any genome sequencing project. Current methods of mRNA isolation depend on the presence of a 3' poly(A) tail. Therefore mRNAs that lack this 3' poly(A)...
Published: 2/24/2009       Inventor(s): Curt Hagedorn
Mitogenic Oxygenase Regulators for Drug Discovery
Applications Can be used as a target for drug discovery, gene therapy and to create a diagnostic tool. These applications are relevant to conditions involving inappropriate cell proliferation (e.g., cancer, atherosclerosis), angiogenesis, and tissue damage associated with inflammatory diseases. Technical Summary Reactive oxygen species (ROS) inc...
Published: 2/24/2009       Inventor(s): David Lambeth, Guang Cheng
MEGA, A Novel Genetic Element that Confers Macrolide Resistance in Streptococcus Pneumoniae
Application Genetic element that confers macrolide drug resistance in Streptococcus pneumoniae for use in patient screening and diagnosis as well as drug development. Key Benefits Genetic element allows identification of Streptococcus pneumoniae strains that are resistant to macrolide antibiotics. Expressed efflux proteins identified by this elem...
Published: 2/24/2009       Inventor(s): David Stephens, Kathryn Gay