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PI3Kα Inhibitors for the Treatment of Cancer Application Compounds that inhibit the kinase activity of phospoinostidie 3-kinase (PI3Kα) for the treatment of cancer. Key Benefits Potential therapeutic targeted to pathway without a clinically approved inhibitor. Provides a useful pharmacological probe for research purposes. Market Summary In order to grow, cancer cells must have the... Published: 4/23/2024       Contributor(s): Qi Shi, Thomas Kaiser, Dennis Liotta, James Snyder, Zackery Dentmon, John Diraddo

Derivatives as CXCR4 Modulators for the Treatment of Inflammation and Metastasis Application Amide derivatives as chemokine receptor type 4 (CXCR4) modulators for the treatment of inflammation or prevention of cancer cell metastasis. Key Benefits Excellent binding affinity, compared to currently available compounds targeting CXCR4 receptor. Stability in plasma compared to protein/peptide agonists of CXCR4, these amide derivatives... Published: 4/23/2024       Contributor(s): Hyunsuk Shim, Renren Bai, Qi Shi