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Positive Allosteric Modulators that Treat Central Nervous System Disorders Application Small molecules that selectively potentiate N-methyl-D-aspartate (NMDA) receptor subunits GluN2C/GluN2D for the treatment of neurological conditions. Key Benefits Selective potentiation of only NMDA receptor that contain GluN2C or GluN2D subunits will likely reduce adverse side effects. Selective potentiation of only NMDA receptor... Published: 4/23/2024       Contributor(s): Stephen Traynelis, Praseeda Mullasseril

Small Molecule Potentiators for Treatment of Central Nervous System Disorders Application Series of compounds for selectively potentiating N-methyl-D-aspartate (NMDA) receptor subunit NR2C for treating central nervous system impairment. Key Benefits Selectivity for NR2C may reduce possibility of adverse side effects. Market Summary N-methyl-D-aspartate (NMDA) receptors are widely dispersed in the central nervous system... Published: 4/23/2024       Contributor(s): Stephen Traynelis, Praseeda Mullasseril, Ethel Garnier-Amblard, Dennis Liotta, Sommer Zimmerman