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Polyketal Nanoparticles to Administer Pharmaceutical Products in Acidic Environments Application Acid-sensitive polyketal nanoparticles for biodegradable drug delivery. Key Benefits Can be engineered to a variety of sizes and shapes to facilitate the delivery of hydrophobic small molecules, proteins, or nucleic acids. Provides a vehicle for delivering therapeutics to acidic environments found in tumors, inflammatory tissues, and... Published: 1/31/2024       Contributor(s): Niren Murthy, Bali Pulendran, Michael Heffeman, Jihua Hao, Marcin Kwissa, Michael E. Davis, Stephen Chen Yang

Tempol-Folate Conjugates to Prevent Oxidative Injury in Tissues Application Targeted anti-oxidative therapy for ischemia-reperfusion injury, hemorrhage, major surgery, kidney transplant, or acute renal failure. Key Benefits Conjugation of Tempol with Folate does not alter the antioxidant property of Tempol. Tempol-Folate conjugates are more effective than Tempol alone at preserving kidney structure and function... Published: 4/23/2024       Contributor(s): Sarah (Knight) Marvar, William Robert Taylor, Niren Murthy, Kousik Kundu