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Novel Inhibitors of NOX2/ROS
ApplicationsNovel therapeutics for treatment of various inflammatory airway conditions including chronic obstructive pulmonary disease (COPD).Key BenefitsNOX2/ROS inhibitors have potential for use in a wide variety of clinical indications. Current treatments are weakly effective or provide only symptomatic relief for inflammatory airway diseases. T...
Published: 2/10/2015       Inventor(s): Thota Ganesh, David Lambeth, Susan Smith, Aiming Sun
Dopaminergic Treatment for Diabetic Retinopathy
Application Repurposed L-DOPA for the treatment of diabetic retinopathy. Key Benefits Shows improved overall retinal and visual function. Delays progression of disease. L-DOPA is an FDA approved drug. Market Summary It is estimated that nearly one in ten people globally will have some form of diabetes by 2035 and diabetic retinopathy affects a ...
Published: 5/30/2014       Inventor(s): Moe Aung, Machelle Pardue, P. Michael Iuvone
Functional Restoration of Diabetic Bone Marrow-Derived Cells
ApplicationMethods for restoration of diabetic bone marrow cell function for cell based therapy, using pre-existing molecules and their derivatives.Key BenefitsAbility to "reactivate" diabetic bone marrow-derived stem or progenitor cells which also include peripheral blood cells such as endothelial progenitor cells. Cells are more angioge...
Published: 2/15/2013       Inventor(s): Young-Sup Yoon, Ji Woong Han
Normalization Procedure for Chemical Profiles in Biological or Medical Samples Detected by Mass Spectrometry
Application Normalization procedure that allows for the direct comparison of high-throughput liquid chromatography/mass spectrometry (LC/MS) metabolomic data gathered from different individuals at different times. Key Benefits Samples used can be collected at different times and/or analyzed by different mass spectrometers. Cumulative datasets ca...
Published: 9/18/2012       Inventor(s): Dean Jones, Quinlyn Soltow, Jennifer Johnson
Insulin-Producing Microcapsules for Treatment of Type 1 Diabetes
Application Transplantation of microcapsules with insulin-producing porcine islet cells for use in Type 1 diabetes. Key Benefits Improved engineering of microcapsules prevents immune activation and microcapsule rejection. Encapsulated islet cells sense blood glucose levels and secrete insulin. Transplanted microcapsules demonstrate a long-term ...
Published: 4/23/2012       Inventor(s): Collin Weber
Growth Factor as a Treatment for Obesity
Applications Therapeutic use of Glial Cell Line-Derived Neurotrophic Factor (GDNF) to treat obesity. Potential drug target for further therapeutic development. Key Benefits Growth Factor expression in the brain causes a reduction in high fat diet-induced obesity. Fat level reduction has been shown in both mouse and human cells. Reducing obesit...
Published: 6/30/2011       Inventor(s): Shanthi Srinivasan
A Small Molecule that Acts as an Insulin Synergistic for the Treatment of Diabetes
Application Non-peptidyl, small molecule that is synergistic with insulin and selectively activates the insulin receptor. Key Benefits Dramatic hypoglycemic effect in normoglycemic and hyperglycemic mice Effectiveness occurs in comparable time as insulin and lasts longer than insulin. Highly selective and sensitive for insulin receptors. Sensit...
Published: 10/11/2010       Inventor(s): Keqiang Ye
Food Lists for Nutritional Management of Metabolic Disorders
ApplicationsBooklets which provide a reference guide for nutritional management of rare genetic diseases.Technical SummaryA majority of inherited metabolic disorders affect children and adults worldwide. Many metabolic disorders require special dietary therapy and monitoring by a team of physicians, nurses, genetic counsellors, social workers, and ...
Published: 4/29/2009       Inventor(s): Rani Singh
Neurotrophic Factor as Therapeutic for Diabetes
Application The use of Glial Cell-derived Neurotrophic Factor (GDNF) or its mimics as a potential therapeutic for diabetes mellitus type 1 (IDDM). Key Benefits GDNF enhances pancreatic β-cell growth and survival in vitro and in vivo. GDNF transgenic mice have lower blood glucose levels and are more resistant to developing diabetes compared w...
Published: 2/24/2009       Inventor(s): Shanthi Srinivasan
Anti-Inflammatory Conformal Barriers for Cell Transplantation
Application Coatings that protect islet cells during transplantation for the treatment of Type I diabetes. Key Benefits Ability to control permeability characteristics of shape conforming barrier coating. Application to genetically engineered cells, neurons, cardiac myoblasts, myocardial cells, chondrocytes, dopamine secreting cells, or other c...
Published: 2/24/2009       Inventor(s): Elliot Chaikof, Zhifei Dai, Wanxing Cui