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CXCR4 Antagonists for the Treatment of Cancer Application Small molecules containing either the piperidine or piperazine core which act as antagonists to C-X-C chemokine receptor type 4 (CXCR4) and may be orally administered. Key Benefits Orally administered CXCR4 antagonists with diverse clinical applications in oncology. Mobilize white blood cells in mice in a dose-dependent manner. Cause... Published: 4/23/2024       Contributor(s): Lawrence (larry) Wilson, Dennis Liotta, John Wiseman, Michael Natchus

Multi-Target CCR5/CXCR4 Chemokine Compounds for the Treatment of HIV Application Chemical compounds that bind to both CCR5 and CXCR4 chemokine GPCRs as therapeutics to block HIV entry and infection. Key Benefits Targets both chemokine receptors used for cell entry by HIV: CCR5 & CXCR4. Eliminates the requirement of a tropism pre-test used for drug administration of single chemokine agents. Does not interfere... Published: 4/23/2024       Contributor(s): Bryan Cox, Lawrence (larry) Wilson, Anthony Prosser, James Snyder, Dennis Liotta