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Strategy to Identify miRNAs for Disease Diagnosis
Application Method to measure precursor and mature miRNA specifically. Key Benefits Unique primers can specifically identify miRNAs and precursor miRNAs by standard qRT-PCR without the requirement for an additional detection probe. Allows for amplification and quantification of both mature miRNA and precursor miRNAs. Potential technology to evaluate...
Published: 1/22/2020       Inventor(s): Wenming Li
Selective Enrichment of A-To-I Edited Transcripts from Cellular RNA Using Endonuclease V
Application Kit to efficiently identify and enrich adenosine-to-inosine (A-to-I) editing in RNA molecules. Key Benefits Robust and facile method for enriching A-to-I edited transcripts. Overcomes the low efficiency and accuracy of transcriptome-wide RNA-seq. Market Summary A-to-I RNA editing by adenosine deaminases is a common RNA modification...
Published: 12/3/2019       Inventor(s): Steven Knutson, Jennifer (Jen) Heemstra
Cas9 Controlled Gene Activation
Application Flexible system using Cas9 to modulate gene expression. Key Benefits Edits genes by cleaving DNA as well as inhibiting transcription. No need to transfect cells with additional Cas9. Market Summary The CRISPR-Cas9 system is a bacterial adaptive immune system that has been appropriated for genetic engineering. The CRISPR-Cas9 system...
Published: 10/11/2019       Inventor(s): David Weiss, Hannah Ratner
DNAzyme Nanoparticles for the Cleavage of RNA
Application Site-selective RNA splicing nanozyme for cleaving and ligating RNA. Key Benefits Can cleave virtually any RNA stem loop. Removes a 19 nucleotide segment from a 67 nucleotide RNA loop with up to 66% efficiency. Technical Summary Modulating RNA can be useful for studying RNA biology, gene knockdown, and regulating RNA splicing. Scientists...
Published: 9/5/2019       Inventor(s): Jessica Petree, Kevin Yehl, Khalid Salaita
Trimeric Immunogen for HIV-1 Vaccination
Application Trimeric gp120 immunogen that induces broadly cross-reactive V1V2-antibodies for HIV-1 vaccine. Key Benefits Possible oral administration. Broadly cross-reactive against HIV-1 panel. Promotes antibody responses as both a primary immunogen and boosting immunogen. Market Summary Antiretroviral therapy (ART) has dramatically prolonged...
Published: 8/26/2019       Inventor(s): Rama Amara, Andrew Jones, Raghavan Varadarajan, Sannula Kesavardhana
Glycoprotein Tetramer for Identifying Antigen-specific B Cells
ApplicationEctodomain of viral glycoprotein tetramers detects antigen-specific memory B Cells.Key BenefitsViral glycoprotein tetramers detect antigen-specific memory B cells in the peripheral blood and tissues.Hepatitis C virus E2 protein triggers immune response, which may yield an effective vaccine against hepatitis C virus.Market SummaryHepatitis...
Published: 5/9/2019       Inventor(s): Arash Grakoui, Joseph Marcotrigiano
IFN╬│ Prelicensing for Improved Mesenchymal Stromal Cell Function Post-Thaw
ApplicationMesenchymal stromal cells (MSC) prelicensed with pro-inflammatory cytokines for improved survival and immunosuppressive properties following cryopreservation.Key BenefitsPreserves the immunosuppressive function of MSCs following thawing.Improves effectiveness of transplanted MSCs following cryopreservation.Market SummaryMesenchymal stromal...
Published: 1/22/2019       Inventor(s): Jacques Galipeau, Raghavan Chinnadurai
Granulin for Treatment of Neurodegeneration
ApplicationGranulin proteins (GRNs) as potential therapeutics for multiple neurodegenerative disorders caused by lysosome dysfunction and inflammation.Key BenefitsNovel pathway and target provides new route for treatment.Granulins shown to rescue lysosomal defects in cell culture models.Market SummaryGranulins are small proteins that are derived by...
Published: 12/18/2018       Inventor(s): Thomas Kukar
TaqMan Array Cards for Pneumococcal Detection and Serotyping
ApplicationDiagnostic for identifying Streptococcus pneumonia serotypes.Key BenefitsAllows for rapid detection and serotype identification of Streptococcus pneumonia infections.Market SummaryStreptococcus pneumonia (Spn) is a gram-positive bacteria and significant human pathogen responsible for most pneumonia cases. Typically, Spn resides asymptomatically...
Published: 4/16/2018       Inventor(s): Jorge Vidal, Fuminori Sakai, Lesley Mcgee, Velusamy Srinivasan
Therapeutic Target for Hepatic Fibrosis
ApplicationPeriostin as a therapeutic target for liver disease.Key BenefitsNew therapeutic target for preventing fibrosis from entering cirrhosis stage.Therapeutic target may be used for identifying new therapy for fibrosis.Market SummaryCirrhosis is a condition in which the liver is unable to function normally due to chronic, or long lasting, injury....
Published: 3/23/2018       Inventor(s): Frank Anania, Pradeep Kumar
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