TaqMan Array Cards for Pneumococcal Detection and Serotyping
ApplicationDiagnostic for identifying Streptococcus pneumonia serotypes.Key BenefitsAllows for rapid detection and serotype identification of Streptococcus pneumonia infections.Market SummaryStreptococcus pneumonia (Spn) is a gram-positive bacteria and significant human pathogen responsible for most pneumonia cases. Typically, Spn resides asymptoma...
Inventor(s): Jorge Vidal graniel, Fuminori Sakai, Lesley Mcgee, Velusamy Srinivasan
Therapeutic Target for Hepatic Fibrosis
ApplicationPeriostin as a therapeutic target for liver disease.Key BenefitsNew therapeutic target for preventing fibrosis from entering cirrhosis stage.Therapeutic target may be used for identifying new therapy for fibrosis.Market SummaryCirrhosis is a condition in which the liver is unable to function normally due to chronic, or long lasting, inju...
Inventor(s): Frank Anania, Pradeep Kumar
Targeting Peptides for Myocarditis
ApplicationTargeting peptide molecule for image-based diagnosis of myocarditis.Key BenefitsEnables noninvasive diagnosis of myocarditis.Targets and binds to biomarker of myocarditis.Market SummaryMyocarditis is an inflammation of the heart muscle (myocardium). Myocarditis can affect your heart muscle and your heart's electrical system, reducing the...
Inventor(s): Michael Davis, Mario Martinez
GeneRegs: Nanoparticles for Treatment of Severe Asthma
ApplicationGold nanoparticles coated with enzyme which specifically targets and degrades asthma-associated inflammation molecules.Key BenefitsSpecifically suppresses asthma associated inflammation.Easy self-administration by inhalation.Market SummaryAsthma is defined as a chronic inflammatory lung disease with significant worldwide morbidity. Curre...
Inventor(s): Khalid Salaita, Cherry Wongtrakool, Kornelia Galior
Desulfitative Redox Catalysis Method for Production of Amide and Peptide Linkages
ApplicationAn efficient and economic catalytic process for forming amide and peptide compounds.Key BenefitsUses more inexpensive reagents compared to other methods.Amide/peptide bond is generated in high yield at or near ambient temperature.Mild reaction conditions prevent generation of impurities.Market SummaryPeptide and amide linkages are import...
Inventor(s): Lanny Liebeskind, Matthew Lindale
DHAA and Derivatives for Treatment of BRAF-V600E-Positive Cancer
ApplicationHypolipidemic dehydroacetic acid (DHAA) treatment to prevent growth of BRAF V600E positive tumors.Key BenefitsTreatment with slows BRAF V600E-positive tumor growth.Repurposed compound may speed FDA approval.May be used in combination with other therapies.Market SummaryAccording to the American Cancer Society, skin cancer is the most comm...
Inventor(s): Jing Chen, Jack Arbiser, Brian Pollack, Siyuan Xia
Bioluminescent Ion Indicator Proteins
ApplicationFusion protein for non-invasive assessment of chloride fluctuations in neuronal processes.Key BenefitsEnables a non-invasive method of imaging chloride in animals.Offers high signal-to-noise ratio compared to fluorescent light.Market SummaryNeuronal chloride (Cl-) is involved in many normal neurophysiological activities, including synapt...
Inventor(s): Robert Gross, Ken Berglund, Jack Tung
Compound and Method to Explore and Prepare O-Glycans from Living Cells
ApplicationChemical compound and method that enables detection of O-glycans with higher sensitivity than conventional approaches.Key BenefitsHigher accuracy and sensitivity than current β-elimination method.Smaller sample quantities required compared to traditional mass spectrometry.Method promotes the discovery of novel glycans and study of c...
Inventor(s): Tongzhong Ju, Richard Cummings, Matthew Kudelka
Membrane-anchored Fusokine as Vaccine Adjuvant to Prevent Viral Infection
ApplicationGIFT4 anchored to virus-like particles (VLPs) as a prophylactic vaccine adjuvant to prevent chronic viral infections including HIV, HBV, HPV and influenza.Key BenefitsGIFT4-containing VLPs induce higher antibody response than non-adjuvanted VLPs. Effectively induce strong mucosal immune response. Market SummaryMore than 36 million people...
Inventor(s): Baozhong Wang, Richard Compans, Jacques Galipeau, Jiusheng Deng
Motion Based Detection by DNA Machines
DNA-based machines that roll rather than walk and can be used for single nucleotide polymorphism (SNP) analysis.
Unique "rolling" cogwheel-like mechanism allows directional motion without a track or external guidance.
Micron-sized cargo travels large distances; can be visualized using a smartphone camera equipped with an ...
Inventor(s): Khalid Salaita, Kevin Yehl