Technology Listings


13 Results Sort By:
Multi-Step DNA “Domino” Nanoarray
Application DNA nanoarray for constructing nanostructures and molecular devices to detect and translate interactions and changes. Key Benefits Transfers information via DNAs shape transformation. Allows high precision and complexity of transformation. Market Summary Information relay at the molecular level, such as the transcription of RNA...
Published: 8/6/2019       Inventor(s): Yonggang Ke, Chengde Mao, Jie Song, Zhe Li, Pengfei Wang, Travis Meyer
Micron-Sized Drug Vehicle for Unregulated Blood Clotting
ApplicationFibrinogen-coated micron-sized drug vehicles for targeted treatment of unregulated blood clotting.Key BenefitsFacilitates targeted release of drugs specifically for blood clotting disorders.Drug delivery vehicle can be used with newly discovered or known therapeutics on the market.Site specific biological mechanism may help increase drug...
Published: 2/20/2017       Inventor(s): Caroline Hansen, Yumiko Sakurai, Wilbur Lam, Andrew Lyon
Anti-biofouling Polymer for Nanoparticle Coating
Application A functionally amenable copolymer of polyethylene glycol (PEG) and allyl glycidyl ether (AGE) that improves the specificity and targeting of nanoparticles compared to PEG coating. Key Benefits Amphiphilic properties significantly reduce non-specific adsorbtion of proteins compared to PEG. Improves targeting and cell-specific uptake o...
Published: 6/1/2016       Inventor(s): Hui Mao, Yuancheng Li, Lily Yang
Motion Based Detection by DNA Machines
Application DNA-based machines that roll rather than walk and can be used for single nucleotide polymorphism (SNP) analysis. Key Benefits Unique "rolling" cogwheel-like mechanism allows directional motion without a track or external guidance. Micron-sized cargo travels large distances; can be visualized using a smartphone camera equipped with an ...
Published: 1/19/2016       Inventor(s): Khalid Salaita, Kevin Yehl
Layer-by-layer Assembled Nanoparticles for Oral Drug Delivery
ApplicationLayered, casein coated magnetic nanoparticles for oral delivery of drugs protected from acid degradation.Key BenefitsEnables oral delivery of hydrophobic drugs that are sensitive to acid degradation in stomach condition. Replaces injections and infusions, reducing side effects and improving patient’s quality of life. Allows magneti...
Published: 4/27/2015       Inventor(s): Hui Mao, Jing Huang
SpineGuide: Magnetic Resonance Imaging-Compatible Spinal Therapeutics Delivery System
ApplicationMRI-compatible device that enables precise delivery of therapeutic or cells to specific locations in the spinal cord. Key BenefitsCompatible with real-time MRI imaging systems allowing for the targeting and delivery of therapies concurrent with imaging. Can precisely guide and deliver a multitude of therapies (small molecules, biologics ...
Published: 1/28/2015       Inventor(s): Nicholas (Nick) Boulis, John Oshinski, Jason Lamanna
Self-Assembling Peptides that Incorporate Cell Signaling Molecules
Application Platform that creates conjugates of self-assembling peptides and cell signaling molecules as a potential therapeutic for the treatment and repair of tissue. Key Benefits Hydrogels form at physiological pH and osmolarity. Produces cells that display characteristics of adult cardiac muscle cells. Additional molecules (pro-growth or pr...
Published: 4/8/2014       Inventor(s): Michael Davis, Archana Boopathy
A Ligand-Protease Fusion Peptide for Enhanced Tumor Targeting and Drug Delivery
ApplicationA ligand-protease fusion peptide that cuts through the tumor stromal barrier and provides enhanced tumor targeting and delivery efficiency for therapeutic agents.Key BenefitsThe protease activity of the fusion peptide enables breaking of the stromal matrix and allows migration into stroma-rich tumor tissues. Can be attached to nanopartic...
Published: 2/25/2014       Inventor(s): Lily Yang, Xiangxue Guo
Polyketal Nanoparticles to Administer Pharmaceutical Products in Acidic Environments
Application Acid-sensitive polyketal nanoparticles for biodegradable drug delivery. Key Benefits Can be engineered to a variety of sizes and shapes to facilitate the delivery of hydrophobic small molecules, proteins, or nucleic acids. Provides a vehicle for delivering therapeutics to acidic environments found in tumors, inflammatory tissues, an...
Published: 11/3/2013       Inventor(s): Niren Murthy, Bali Pulendran, Michael Heffeman, Jihua Hao, Marcin Kwissa, Michael Davis, Stephen Chen Yang
A Multifunctional Nanoparticle siRNA Delivery System
Application Tumor receptor-targeted nanoparticle containing a siRNA DNA cassette for the knockdown of survival genes and treating cancer. Key Benefits Nanoparticles are targeted directly to tumors for treatment and/or diagnostic imaging. siRNA encoded by a DNA cassette has increased stability and more effective gene depletion. siRNA knockdown o...
Published: 3/27/2013       Inventor(s): Lily Yang
1 2