|
Progesterone to Treat Traumatic Brain Injury
Application
The use of progesterone to treat patients with traumatic brain injury (TBI) via a tapered administration protocol.
Key Benefits
Early administration of progesterone reduces cerebral edema and neural loss, and improves behavioral recovery from traumatic brain injury (TBI) in pre-clinical animal models.
Tapered progesterone withdrawal...
Published: 7/28/2023
Contributor(s): Donald Stein, Stuart Wayne Hoffman, Arthur Kellermann, David Wright, Douglas Lowery-North, Sarah Cutler
|
|
Synthetic Analogues of Progesterone
Application
Therapeutic treatment of traumatic brain injury and other uses of progesterone where composition of matter intellectual property are required.
Key Benefits
20 fold increase in solubility relative to the hormone progesterone.
Synthetic analogues are as effective as progesterone in reducing cerebral edema following traumatic brain injury....
Published: 4/23/2024
Contributor(s): Dennis Liotta, Christopher Macnevin, Donald Stein, Michael Natchus, David Guthrie, Mark Lockwood, Iqbal Sayeed
|
|
Progesterone Shows Promise in Treating CNS Tumors
ApplicationTreatment for neuroblastoma and other tumors in the central nervous system.Key BenefitsInduces cell death in tumor cells while having no negative effects on surrounding neurons. Slows the rate of neuroblastoma tumor growth. Technical SummaryEmory researchers have shown that progesterone caused significant cell death in tumor cells while remaining...
Published: 4/23/2024
Contributor(s): Donald Stein, Iqbal Sayeed, Fahim Atif
|