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Organocatalysts for Amide Bond Formation
ApplicationChemically catalyzed amide bond formation under mild reaction conditions.Key BenefitsEnables amide bond formation under mild reaction conditions.Organocatalyst are easily synthesized.Avoids the use and disposal of hazardous chemicals.Market SummaryAmide bonds are very frequently incorporated into active pharmaceutical ingredients (API). ...
Published: 4/6/2018       Inventor(s): Lanny Liebeskind, Pavan Kumar Reddy Gangireddy, Sri Rama Murthy Akondi, Vidyavathi Patro, Nikolay Orlov
Desulfitative Redox Catalysis Method for Production of Amide and Peptide Linkages
ApplicationAn efficient and economic catalytic process for forming amide and peptide compounds.Key BenefitsUses more inexpensive reagents compared to other methods.Amide/peptide bond is generated in high yield at or near ambient temperature.Mild reaction conditions prevent generation of impurities.Market SummaryPeptide and amide linkages are import...
Published: 11/16/2017       Inventor(s): Lanny Liebeskind, Matthew Lindale
Polymer that Neutralizes Toxic Chemical Threats
ApplicationA multifunctional polymer that captures and degrades chemical threats in the environment.Key BenefitsForms a gel that entraps toxic materials within seconds of contact.Visible color change of gel confirms neutralization of toxic substance.Modifiable structure allows for functional use against chemical entity of choice.Market SummaryToxic...
Published: 3/29/2017       Inventor(s): Craig Hill, Kevin Sullivan
Motion Based Detection by DNA Machines
Application DNA-based machines that roll rather than walk and can be used for single nucleotide polymorphism (SNP) analysis. Key Benefits Unique "rolling" cogwheel-like mechanism allows directional motion without a track or external guidance. Micron-sized cargo travels large distances; can be visualized using a smartphone camera equipped with an ...
Published: 1/19/2016       Inventor(s): Khalid Salaita, Kevin Yehl
OSIRIS: An Information Management Application for Use in Drug Discovery and Development
Application A web-based information management application for data tracking and sharing during the discovery and development of new small molecule therapeutics. Key Benefits Can be used to register compounds and display information about chemical structures and calculations. Easily customizable and has a ticket system to allow administrators to ...
Published: 6/21/2013       Inventor(s): Serdar Kurtkaya, Iestyn Lewis, Michael Natchus, James Snyder
Robust Water Oxidation Catalyst for Hydrogen Fuel Production
Application Oxidation catalysts for sunlight driven H2 fuel production. Key Benefits Faster reactivity compared to previously disclosed water oxidation catalysts (WOCs). Hydrolytic stability exceeds that observed for earlier catalysts. Easily prepared from readily available materials. Market Summary Hydrogen fuel is currently considered a poten...
Published: 1/17/2013       Inventor(s): Craig Hill, Iourii (yurii) Gueletii, Jie Song, Hongjin Lv, Djamaladdin (jamal) Musaev, Zhen Luo
Normalization Procedure for Chemical Profiles in Biological or Medical Samples Detected by Mass Spectrometry
Application Normalization procedure that allows for the direct comparison of high-throughput liquid chromatography/mass spectrometry (LC/MS) metabolomic data gathered from different individuals at different times. Key Benefits Samples used can be collected at different times and/or analyzed by different mass spectrometers. Cumulative datasets ca...
Published: 9/18/2012       Inventor(s): Dean Jones, Quinlyn Soltow, Jennifer Johnson
A Nanorod-Based System for Efficient Conversion of Sunlight into Hydrogen
Application Water-soluble semiconductor nanorod crystals that allow for efficient light-driven hydrogen production. Key Benefits Provides almost 100% quantum efficiency for photoreduction of a redox mediator during solar-to-fuel conversion for use in batteries, fuel cells, and other energy sources. Provides unique absorption properties, larger ex...
Published: 7/30/2012       Inventor(s): Tianquan (tim) Lian, Haiming Zhu
Shotgun Glycomics: A Microarray Strategy for Functional Glycomics
ApplicationMicroarray based strategy for functional analyses of complex cellular glycomes.Key BenefitsIdentifies functionally relevant glycans. Allows focused structural analyses of biologically important glycans. New approach to label glycosphingolipids that retains their protein binding. Technical SummaryGlycans mediate crucial cell-cell, cell-pr...
Published: 4/10/2012       Inventor(s): Richard Cummings, David Smith, Xuezheng Song
Synthesis of Enigmol and its Analogues
Application Optically pure D-erythro-Sphingosine that can be produced with high yield.Key Benefits Novel method efficiently produces D-erythro-Sphingosine and derivatives in bulk and with high optical purity. D-erythro-Sphingosine can be converted to many other sphingolipids for use in the production of therapeutics and cosmetics. Technical Summary...
Published: 8/30/2011       Inventor(s): Lanny Liebeskind, Ethel Garnier-Amblard, Dennis Liotta
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