Reovirus Treatment of Triple-Negative Breast Cancer
ApplicationTherapeutic oncolytic reovirus for treatment of triple-negative breast cancer.Key BenefitsSpecific for Triple-Negative Breast cancer.Can be a good candidate for combination therapy.Market SummaryTriple-negative breast cancer (TNBC) constitutes approximately 15% of all breast cancer, has a higher rate of relapse, and shorter overall survi...
Inventor(s): Bernardo Mainou, Roxana Rodriguez, Angela Berger
IFNγ Prelicensing for Improved Mesenchymal Stromal Cell Function Post-Thaw
ApplicationMesenchymal stromal cells (MSC) prelicensed with pro-inflammatory cytokines for improved survival and immunosuppressive properties following cryopreservation.Key BenefitsPreserves the immunosuppressive function of MSCs following thawing.Improves effectiveness of transplanted MSCs following cryopreservation.Market SummaryMesenchymal strom...
Inventor(s): Jacques Galipeau, Raghavan Chinnadurai
Engineered lmmunocompetent Cellular Therapy for T Cell Leukemia
ApplicationCell therapy which circumvents fratricide by alteration of the expression of CD5 on CD5-targeting Chimeric Antigen Receptor (CAR)-T cells.Key BenefitCircumvents self-recognition of the CAR-T cell product thereby improving the effectiveness of CAR-T therapy for T-cell malignancies.Market SummaryChimeric antigen receptor T cells (CAR-T cel...
Inventor(s): H. Trent Spencer, Christopher Doering, Sunil Raikar, Lauren Fleischer
Small Molecules for Development of Cardiac Chamber-Specific Myocytes
ApplicationSmall molecule activators and inhibitors of retinoic acid (RA) to create chamber-specific myocytes from pluripotent stem cells without cell sorting.Key BenefitsProduces highly-enriched, subtype-specific populations of cardiac myocytes.Eliminates need for cell-sorting.Does not require transgenic changes to the human stem cells.Market Summ...
Inventor(s): Hee Cheol Cho, Pengcheng Han
Genetic Mutation in Immune Cells for Infectious Disease and Cancer Therapy
ApplicationConditional epigenetic mutation in CD8+ memory T cells as potential cell therapy for chronic viral infection and personalized cancer treatment.Key BenefitsBlocks DNA methylation in T cells, prolonging the life and enhancing the function of these cells.Results in faster CD62L re-expression during effector to memory cell conversion.Delays ...
Inventor(s): Benjamin Youngblood, Rafi Ahmed
hPSC-Derived Endothelial Cell Generation System
ApplicationClinically compatible cell culture system to generate endothelial cells (EC) from human pluripotent stem cells (hPSC).Key BenefitsProduces hPSC-ECs in high yield.Compatible with clinical applications of hPSC-derived endothelial cells.Engrafted cells survive longer (>10 months) than in prior published research (weeks).Market SummaryAcc...
Inventor(s): Young-Sup Yoon, Shin-Jeong Lee, Ho-Wook Jun
Platelet Lysate Gel for Wound Healing and Revascularization Therapy
ApplicationPlatelet lysate (PL) gel for localized growth factor delivery, wound healing and as a delivery vehicle for cellular therapies.Key BenefitsIncreases human mesenchymal stem cell (MSC) expansion capacity compared to fetal bovine serum.Derived from human blood products, reducing risk of contamination from foreign organism.Enables use of lowe...
Inventor(s): Luke Brewster, Scott Robinson, Ian Copland
Microfluidic Device for Increased Viral Transduction Efficiency
ApplicationMicrofluidic chip device for facilitating high throughput viral transduction for gene therapy applications.Key BenefitsImproves surface-to-volume ratio, allowing more efficient contact between lentiviruses and cellsIncreases efficiency while maintaining cell viability of traditional methods.Enables gene transfer for non-adherent cells.Co...
Inventor(s): Reginald Tran, Wilbur Lam, David Myers, Christopher Doering, H. Trent Spencer
Tool for Measuring Cell Purity and Quality Control of Stem Cell-based Products
ApplicationCell-based assay for sensitive and specific detection of undifferentiated cells in stem cell-related research and development.Key BenefitsNanotechnology-based assay can detect residual undifferentiated cells and characterize cultures that may be tumorigenic. Technology is potentially more sensitive method compared to current methods. Mar...
Inventor(s): Chunhui Xu, Shuming Nie, Ximei Qian, Jingjia Han
Reprogramming of Fibroblasts toward a Three-Dimensional Vascularized Cardiomimetic Tissue (CMT)
Fibroblasts reprogrammed into tissue-like patch including functional cardiomyocyte, endothelial, smooth muscle and pericyte cells for treatment of cardiac diseases.
Enables simultaneous reprogramming of multi-lineage cells including cardiomyocytes and endothelial cells
Increases expression of cardioprotective paracrine fa...
Inventor(s): Young-Sup Yoon, Jaeyeaon Cho