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Biomarker for Clinical Prognosis for Lung Cancer Patients
Application Biomarker to predicting clinical outcome and treatment options for lung cancer patients. Key Benefits Provides early determination of prognosis. Market Summary Upon diagnosis with cancer, there are many different treatment options. While some more aggressive treatment options can be more dangerous to the patient, these aggressiv...
Published: 7/2/2019       Inventor(s): Adam Marcus, Brian Pedro, Jessica Konen
Theranostic Biomarker for Aspirin-Exacerbated Respiratory Disease
Application Biomarkers for a clinical diagnostic tool and non-psychogenic therapy to detect and treat aspirin-exacerbated respiratory disease. Key Benefits Does not rely on aspirin challenge, increasing safety and availability for suspected patients. May be used in patients who have respiratory compromise or are not stable. Minimally-invasiv...
Published: 7/2/2019       Inventor(s): Joshua Levy, Samuel Molina
Combination Therapy for Increasing Venetoclax Sensitivity in Multiple Myeloma
Application Marker and co-therapy that inhibits succinate dehydrogenase to increase patient response to venetoclax. Key Benefits Co-therapy increases MM sensitivity to venetoclax treatment. Identifies patients who will respond to venetoclax therapy. Market Summary Multiple Myeloma (MM) is a cancer of plasma cells responsible for making ant...
Published: 6/18/2019       Inventor(s): Malathy (mala) Shanmugam, Richa Bajpai
Targeting Peptides for Myocarditis
ApplicationTargeting peptide molecule for image-based diagnosis of myocarditis.Key BenefitsEnables noninvasive diagnosis of myocarditis.Targets and binds to biomarker of myocarditis.Market SummaryMyocarditis is an inflammation of the heart muscle (myocardium). Myocarditis can affect your heart muscle and your heart's electrical system, reducing the...
Published: 2/7/2018       Inventor(s): Michael Davis, Mario Martinez
RNA Biomarkers for Coronary Artery Disease (CAD)
ApplicationDiagnostic panel to determine severity of coronary artery disease using plasma-based biomarkers of microparticle vesicles and isoforms of specific miRNAs (isomiRs).Key BenefitsPredictive risk diagnostic aids in clinicians' course of treatment decisions.Identifies underlying biological function of biomarkers for potential use of personali...
Published: 11/9/2017       Inventor(s): Charles Searles, Jr., Amanda James
Bioluminescent Ion Indicator Proteins
ApplicationFusion protein for non-invasive assessment of chloride fluctuations in neuronal processes.Key BenefitsEnables a non-invasive method of imaging chloride in animals.Offers high signal-to-noise ratio compared to fluorescent light.Market SummaryNeuronal chloride (Cl-) is involved in many normal neurophysiological activities, including synapt...
Published: 9/26/2017       Inventor(s): Robert Gross, Ken Berglund, Jack Tung
Compound and Method to Explore and Prepare O-Glycans from Living Cells
ApplicationChemical compound and method that enables detection of O-glycans with higher sensitivity than conventional approaches.Key BenefitsHigher accuracy and sensitivity than current β-elimination method.Smaller sample quantities required compared to traditional mass spectrometry.Method promotes the discovery of novel glycans and study of c...
Published: 5/25/2017       Inventor(s): Tongzhong Ju, Richard Cummings, Matthew Kudelka
Biomarkers for Diagnosis and Treatment Management of Tuberculosis
Application Biomarkers to diagnose active and latent tuberculosis infection and monitor treatment regimen. Key Benefits Three biomarkers accurately distinguish active tuberculosis (TB) from latent TB infections with 100% specificity and greater than 96% sensitivity. Faster and more accurate test to monitor treatment response among active tubercul...
Published: 6/1/2015       Inventor(s): Jyothi Rengarajan, Toidi Adejanbi, Chris Ibegbu
Biomarker Assay to Predict Small Cell Lung Cancer Responsiveness to Platinum Chemotherapy Agents
Application Tumor biopsy-based genetic biomarker test for selecting the appropriate chemotherapy for small cell lung cancer (SCLC) patients. Key Benefits Panel allows physicians to predict the responsiveness of SCLC to cisplatin or other platinum chemotherapy agents, thereby avoiding use of potentially ineffective chemotherapies. Currently, the...
Published: 7/31/2014       Inventor(s): Taofeek Owonikoko
Biomarker and Treatment for Muscle Wasting
ApplicationA genetic biomarker for the detection and treatment of muscle atrophy.Key BenefitsRemains stable in body fluids including urine and blood to enable non-invasive detection. Is simpler and less expensive than CT/MRI scans for detecting muscle wasting. Identifies skeletal muscle atrophy without the need for muscle biopsy. Market SummaryTher...
Published: 5/30/2014       Inventor(s): Matthew Hudson, Stephen (russ) Price
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