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Biologic Therapeutic for Graft-versus-Host Disease (GvHD) Application Biotherapeutic activation of toll-like receptor 5 (TLR5) to treat graft-versus-host disease (GvHD). Key Benefits Administration of flagellin reduces both acute and chronic GvHD. Contrary to immunosuppressive drugs, flagellin enhances immunity and protects patients from opportunistic infections. Market Summary Transplant recipients... Published: 4/23/2024       Contributor(s): Mohammad Hossain, Andrew Gewirtz, John Roback, Edmund Waller

Flagellin Fragments as Potential Treatment for Chronic Viral Infections Application The use of flagellin and its fragments for treating chronic viral infections (CVI) including infections caused by HIV, Hepatitis viruses, Rotaviruses and Cytomegalovirus. Key Benefits Administration of Toll-like receptor-5 (TLR5) agonist - flagellin resolves a chronic rotaviral infection in mice. Flagellin protects mice from rotavirus... Published: 4/23/2024       Contributor(s): Andrew Gewirtz, Benyue Zhang