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IFN╬│ Prelicensing for Improved Mesenchymal Stromal Cell Function Post-Thaw
ApplicationMesenchymal stromal cells (MSC) prelicensed with pro-inflammatory cytokines for improved survival and immunosuppressive properties following cryopreservation.Key BenefitsPreserves the immunosuppressive function of MSCs following thawing.Improves effectiveness of transplanted MSCs following cryopreservation.Market SummaryMesenchymal strom...
Published: 1/22/2019       Inventor(s): Jacques Galipeau, Raghavan Chinnadurai
Engineered lmmunocompetent Cellular Therapy for T Cell Leukemia
ApplicationCell therapy which circumvents fratricide by alteration of the expression of CD5 on CD5-targeting Chimeric Antigen Receptor (CAR)-T cells.Key BenefitCircumvents self-recognition of the CAR-T cell product thereby improving the effectiveness of CAR-T therapy for T-cell malignancies.Market SummaryChimeric antigen receptor T cells (CAR-T cel...
Published: 12/18/2018       Inventor(s): H. Trent Spencer, Christopher Doering, Sunil Raikar, Lauren Fleischer
Granulin for Treatment of Neurodegeneration
ApplicationGranulin proteins (GRNs) as potential therapeutics for multiple neurodegenerative disorders caused by lysosome dysfunction and inflammation.Key BenefitsNovel pathway and target provides new route for treatment.Granulins shown to rescue lysosomal defects in cell culture models.Market SummaryGranulins are small proteins that are derived by...
Published: 12/18/2018       Inventor(s): Thomas Kukar
PLK1 Inhibitors for the Diagnosis and Treatment of Small Cell Lung Carcinoma (SCLC)
ApplicationPolo Like Kinase 1 (PLK1) inhibitor as a potent treatment strategy for SCLC patients with a specific TP53 mutation.Key BenefitsA personalized cell therapy for recurrent SCLC cases.Higher efficiency in TP53 mediated PLK1 inhibition to control carcinoma.PLK1, a predictive biomarker for SCLC diagnosis.Market SummaryLung cancer is the most c...
Published: 12/6/2018       Inventor(s): Taofeek Owonikoko
Cancer Cell Metabolism Inhibitors for Targeted Therapies
ApplicationGlutamate dehydrogenase (GDH1) inhibitors targeting cancer cell metabolic pathways.Key BenefitsTargets tricarboxylic acid (TCA) cycle/mitochondrial metabolism utilized by several cancer cell types for cell growth and survival.Reduces cell proliferation and viability in several tumor derived cell lines as well as in xenograft tumor models...
Published: 12/6/2018       Inventor(s): Sumin Kang, Jing Chen, Lingtao Jin
Small Molecules for Development of Cardiac Chamber-Specific Myocytes
ApplicationSmall molecule activators and inhibitors of retinoic acid (RA) to create chamber-specific myocytes from pluripotent stem cells without cell sorting.Key BenefitsProduces highly-enriched, subtype-specific populations of cardiac myocytes.Eliminates need for cell-sorting.Does not require transgenic changes to the human stem cells.Market Summ...
Published: 11/16/2018       Inventor(s): Hee Cheol Cho, Pengcheng Han
Biological Pacemakers as Alternatives/Adjuncts to Electronic Pacing Devices
ApplicationNon-viral gene delivery and a small molecule that converts heart muscle cells to pacemaker cells for the device-free treatment of slow heart rhythm.Key BenefitsMinimally invasive procedure provides cardiac pacing without device implant.Restores natural heart rhythm.Eliminates or reduces significant complications such as repeat surgeries ...
Published: 11/16/2018       Inventor(s): Hee Cheol Cho, Jun Li
Genetic Mutation in Immune Cells for Infectious Disease and Cancer Therapy
ApplicationConditional epigenetic mutation in CD8+ memory T cells as potential cell therapy for chronic viral infection and personalized cancer treatment.Key BenefitsBlocks DNA methylation in T cells, prolonging the life and enhancing the function of these cells.Results in faster CD62L re-expression during effector to memory cell conversion.Delays ...
Published: 11/14/2018       Inventor(s): Benjamin Youngblood, Rafi Ahmed
Small Molecules for Treating Multiple Myeloma
ApplicationSmall molecule inhibitor of glucose transporter isoform 4 (GLUT4) for the treatment of cancer.Key BenefitsInhibits glucose uptake in myeloma cells, reducing cell proliferation.Sensitizes multiple myeloma cells to standard therapeutics.Market SummaryEach year in the United States almost 30,000 new cases of multiple myeloma (MM) are diagno...
Published: 4/17/2018       Inventor(s): Malathy (mala) Shanmugam, Gary Schiltz, Rama Mishra, Paul Hruz
Therapeutic Target for Hepatic Fibrosis
ApplicationPeriostin as a therapeutic target for liver disease.Key BenefitsNew therapeutic target for preventing fibrosis from entering cirrhosis stage.Therapeutic target may be used for identifying new therapy for fibrosis.Market SummaryCirrhosis is a condition in which the liver is unable to function normally due to chronic, or long lasting, inju...
Published: 3/23/2018       Inventor(s): Frank Anania, Pradeep Kumar
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