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Small Molecules for Treating Multiple Myeloma
ApplicationSmall molecule inhibitor of glucose transporter isoform 4 (GLUT4) for the treatment of cancer.Key BenefitsInhibits glucose uptake in myeloma cells, reducing cell proliferation.Sensitizes multiple myeloma cells to standard therapeutics.Market SummaryEach year in the United States almost 30,000 new cases of multiple myeloma (MM) are diagno...
Published: 4/17/2018       Inventor(s): Malathy (mala) Shanmugam, Gary Schiltz, Rama Mishra, Paul Hruz
Therapeutic Target for Hepatic Fibrosis
ApplicationPeriostin as a therapeutic target for liver disease.Key BenefitsNew therapeutic target for preventing fibrosis from entering cirrhosis stage.Therapeutic target may be used for identifying new therapy for fibrosis.Market SummaryCirrhosis is a condition in which the liver is unable to function normally due to chronic, or long lasting, inju...
Published: 3/23/2018       Inventor(s): Frank Anania, Pradeep Kumar
Small Molecules to Promote Bone Growth
ApplicationCarrier-linked small molecules that disrupt noggin function and promote bone and cartilage growth.Key BenefitsReduces the patient's dosage of recombinant bone morphogenetic proteins (rhBMP)Improves the effectiveness of less potent bone inducers.Small molecules are cheaper to manufacture, and store compared to protein biologic rhBMP.Reduc...
Published: 1/21/2018       Inventor(s): Scott Boden, Sreedhara Sangadala
Diarylmethanes for Treatment of Melanoma
ApplicationSmall molecule compounds to downregulate Sox2 and reduce growth of melanoma.Key BenefitsInhibits growth of drug resistant melanoma.Shows potential to be more effective than imipramine blue.Market SummaryThe American Cancer Society recognizes that melanoma is the most common and deadliest form of skin cancer. Worldwide 132,000 new cases o...
Published: 1/3/2018       Inventor(s): Jack Arbiser
hPSC-Derived Endothelial Cell Generation System
ApplicationClinically compatible cell culture system to generate endothelial cells (EC) from human pluripotent stem cells (hPSC).Key BenefitsProduces hPSC-ECs in high yield.Compatible with clinical applications of hPSC-derived endothelial cells.Engrafted cells survive longer (>10 months) than in prior published research (weeks).Market SummaryAcc...
Published: 12/11/2017       Inventor(s): YounG-Sup Yoon, ShiN-Jeong Lee, HO-Wook Jun
Vanadium-Containing Nanoscale Molecules as Cancer Killing Drugs
ApplicationUse of nanoscale vanadium containing compounds for the treatment of cancers.Key BenefitsPotent anti-cancer compound is effective against many drug-resistant types of cancers.Anti-cancer mechanism inhibits tumor growth with almost no organ toxicity.Compound can be synthesized at low cost.Market SummaryCancer is the leading cause of death ...
Published: 12/4/2017       Inventor(s): Jie Song, Shuming Nie, Craig Hill
GeneRegs: Nanoparticles for Treatment of Severe Asthma
ApplicationGold nanoparticles coated with enzyme which specifically targets and degrades asthma-associated inflammation molecules.Key BenefitsSpecifically suppresses asthma associated inflammation.Easy self-administration by inhalation.Market SummaryAsthma is defined as a chronic inflammatory lung disease with significant worldwide morbidity. Curre...
Published: 12/4/2017       Inventor(s): Khalid Salaita, Cherry Wongtrakool, Kornelia Galior
Small Molecule NOX Inhibitors of Human Melanoma Cell Proliferation
ApplicationTriphenylmethane small molecules inhibiting NADPH oxidase (NOX) for the anti-proliferation of melanoma tumor cells.Key BenefitsModifies molecular interactions with cellular proteins, reducing cell tumor growth.Compounds are capable of inhibiting cell proliferation to a greater extent than current competing NOX inhibitors for melanoma cel...
Published: 12/4/2017       Inventor(s): Jack Arbiser
DHAA and Derivatives for Treatment of BRAF-V600E-Positive Cancer
ApplicationHypolipidemic dehydroacetic acid (DHAA) treatment to prevent growth of BRAF V600E positive tumors.Key BenefitsTreatment with slows BRAF V600E-positive tumor growth.Repurposed compound may speed FDA approval.May be used in combination with other therapies.Market SummaryAccording to the American Cancer Society, skin cancer is the most comm...
Published: 10/26/2017       Inventor(s): Jing Chen, Jack Arbiser, Brian Pollack, Siyuan Xia
Platelet Lysate Gel for Wound Healing and Revascularization Therapy
ApplicationPlatelet lysate (PL) gel for localized growth factor delivery, wound healing and as a delivery vehicle for cellular therapies.Key BenefitsIncreases human mesenchymal stem cell (MSC) expansion capacity compared to fetal bovine serum.Derived from human blood products, reducing risk of contamination from foreign organism.Enables use of lowe...
Published: 10/26/2017       Inventor(s): Luke Brewster, Scott Robinson, Ian Copland
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