Technology Listings


Platform for Transducing Target Cells with a Viral Vector

Application

System for quickly and efficiently obtaining therapeutic levels of transduction.

Key Benefits
  • Uses less viral vector to achieve high gene transfer.
  • Shortens transduction time.
  • Produces clinically relevant gene modified cell numbers.
Market Summary

Information relay at the molecular level, such as the transcription of RNA into proteins, is an essential process. It is challenging to impart this type of complex dynamic behavior at a synthetic molecular level. DNA self-assembly is the current approach, however the current systems typically exhibit simple dynamic behaviors that involve, at most, only a few transformations.

Technical Summary

Emory researchers have developed a more efficient system to quickly and efficiently achieve therapeutic levels of cells transduced with viral vectors containing the desired gene therapy. This microfluidic platform can be scaled up, using a modular approach, to accommodate clinically relevant numbers of cells (≥1x109). This scalable microfluidic platform uses less viral vector, reduces transduction times, and synergizes with commercially available transduction enhancing compounds.

Developmental Stage

Publications: Tran, R. et al. (2017). Molecular Therapy, 25(10), 2372-82.

Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
PCT PCT PCT/US2020/028006   4/13/2020   10/12/2021 Pending
Tech ID: 19135
Published: 1/23/2020
Category
Micro and Nanotechnology
Research Tools

Contact
David Mudd
Contract Specialist
Emory University
dmudd@emory.edu

Inventor(s)
Reginald Tran
Wilbur Lam
Christopher Doering
H. (Harold) Trent Spencer

Keywords
Cell/Gene Therapy
Platform