Technology Listings

The Antitussive Drug Noscapine & its Derivatives as Anti-Tumor Agents


Can be used for the treatment of neoplastic disease.


A variety of chemotherapeutic agents interact with tubulin, the major protein of mitotic spindles, resulting in mitotic arrest and ultimately cell death in rapidly dividing cells. Athough tubulin-targeting agents are capable of arresting cells in mitotis, these drugs indiscriminantly target both neoplastic and healthy cells resulting in toxic side effects. Thus, there is an urgent need to direct research efforts towards developing more specific chemotherapeutic agents.

The Joshi laboratory has identified noscapiane, an opium alkaloid, which arrests a variety of tumor cells in mitosis. Cough suppression was the only pronounced pharmacologic effect of noscapine known for over thirty years until the Joshi lab demonstrated that noscapine: 1) binds to tubulin and alters its conformation and assembly properties; 2) interferes with microtubule dynamics both in vitro and in living cells; 3) arrests a variety of mammalian cells in mitosis and targets them for apoptosis; and 4) oral administration inhibits the growth of murine thymoma, human breast, bladder, and melanoma tumor cells, and murine and human gliolbastoma cells by inducing polyploidy and apoptosis.

In contrast to other microtubule interacting agents such as paclitaxel, nocodazole, and vinblastine, noscapine modifies microtubule dynamics without affecting total tubulin polymer mass in reconstituted systems and without altering the steady-state monomer/polymer equilibrium of microtubule assembly in cells.  In addition, noscapine does not appear to cause the toxic side effects associated with other microtubule targeting agents such as alopecia, diarrhea, nausea, and peripheral neuropathy.


Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Continuation in Part United States 10/056,913 6,673,814 1/25/2002 1/6/2004 1/6/2024 Issued
Tech ID: NCS.05
Published: 6/6/2013

Rajsekhar Guddneppanavar
Licensing Associate
Emory University

Harish Joshi
Judith Kapp
Yong Ke
Fuqiang Liu
Keqiang Ye
Jaren Landen
David Archer
Cheryl Armstrong

Small Molecule