DNA nanoarray for constructing nanostructures and molecular devices to detect and translate interactions and changes.
- Transfers information via DNAs shape transformation.
- Allows high precision and complexity of transformation.
Information relay at the molecular level, such as the transcription of RNA into proteins, is an essential process. It is challenging to impart this type of complex dynamic behavior at a synthetic molecular level. DNA self-assembly is the current approach, however the current systems typically exhibit simple dynamic behaviors that involve, at most, only a few transformations.
Emory researchers, in collaboration with Georgia Tech and Purdue University, have developed arrays of modular DNA units that can relay information by transforming their shape in response to the binding of DNA triggers. These DNA tiles create a transformative cascade, relaying information about where the DNA trigger bound. This array relay’s transformation from one configuration to another can be designed and controlled. The transformation can be blocked and resumed at any designated location. This DNA nanoarray has applications in bionanotechnology, nanomedicine, and other forms of DNA nanotechnology.
Researchers are currently developing more complex transformations in these DNA arrays.
Publications: Song, J. et al. (2017). Science, 357(6349), p.eaan3377.