ß-secretase (BACE) Monoclonal Antibody
Applications
- Immunohistochemistry
- Western Blot
- Immunprecipitation
Specificity
β -secretase (BACE) of mouse, rat, and human origin.
Subtype
Mouse Monoclonal
Technical Summary
β -secretase (BACE) is an aspartic-acid protease important to the formation of the amyloid-β peptides that form senile plaques in brains of Alzheimer's disease patients. Additionally, it is also involved in the formation of myelin sheaths in the peripheral nervous system. Two sets of monoclonal antibodies have been generated, one targeting the cytoplasmic region of BACE, and a second targeting the lumenal region. These antibodies show no cross reactivity with other secretase enzymes and have been used for immunofluorescence staining, western blotting, and immunoprecipitation applications.
Publications
Shiba et al. Traffic, 2004. 5:437
Fukumoto et al. Amer J Pathol, 2004. 164:719-725
He, et al. Nature Med, 2004. 10:959-965
Kametaka et al. J Biol Chem, 2003. 278:15239-15245
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