Technology Listings


Respiratory Syncytial Virus Strain A2-2-20F

Application

Strain of respiratory syncytial virus (RSV) for vaccine and therapeutic research and development.

Key Benefits
  • Higher early viral load.
  • Induces greater necrotic airway damage and neurophil infiltration.
Market Summary

RSV is a highly contagious and ubiquitous virus that causes respiratory tract infections in individuals of all ages, particularly young children and the elderly. In the US, 75,000-125,000 RSV-related hospitalizations are reported annually among infants <1 year of age. Worldwide the virus is also responsible for 160,000 deaths per year. Currently, no effective vaccine against RSV exists and treatment is limited to a non-vaccine prophylactic medication and supportive care.

Technical Summary

Researchers generated a recombinant F-chimeric RSV by replacing the F gene of A2 with the F gene of line 2-20, generating A2-2-20F. Infection of mice with this line resulted in a higher early viral load and higher levels of subsequent pulmonary mucin expression than infection with the A2 strain. A2-2-20F infection induced greater necrotic airway damage and neurophil infiltration than A2 infection. This leads to death in most mice infected. Combined these effects make this viral line a strong candidate for use during in vivo testing of vaccine or small molecules for RSV.

Developmental Stage

This strain has been developed and used for vaccine candidate screening in the lab.

Patent Information
Tech ID: 15113
Published: 10/16/2018
Category
Research Tools

Contact
Sarah Wilkening
Licensing Associate
Emory University
(404) 727-1969
sarah.wilkening@emory.edu

Inventor(s)
Martin Moore

Keywords
Microbiology/Infectious Diseases
Respiratory