Technology Listings


Dystonia Knock-in Mouse Model

Application
  • Knock-in mouse model for study of L-DOPA responsive dystonia.
  • Useful for other movement disorders like dystonia and Parkinson’s disease.
Technical Summary

Dystonia is a neurological movement disorder characterized by persistent or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both. There are multiple forms of dystonia, and dozens of diseases and conditions may include dystonia as a symptom. Emory researchers have developed a mouse model that carries a human dystonia-causing gene, express dystonia, and responds to other treatments known to ameliorate dystonia. The mouse model carries a point mutation shown to cause a recessive L-DOPA responsive dystonia; however, it may be useful for other movement disorders like Parkinson’s disease.

Publication: Rose, S. J. et al. (2015). Brain, 138 (10), 2987-3002.

Patent Information
Tech ID: 17145
Published: 1/21/2018
Category
Research Tools

Contact
Justin Burns
Assistant Director, Licensing
Emory University
404-727-4968
justin.burns@emory.edu

Inventor(s)
Ellen Hess
Hyder Jinnah

Keywords
Animal Model
Neuroscience/Pain