Technology Listings


Antibody Therapy for Varicella Zoster Virus

Application

Human monoclonal antibodies for the treatment of varicella zoster virus (VZV).

Key Benefits
  • Human monoclonal antibodies can limit the spread of VZV.
  • gH-specific antibodies are complement-independent.
Market Summary

Varicella Zoster Virus (VZV) causes varicella, more commonly known as chickenpox. Once the illness resolves, the virus remains dormant and can later become reactive causing herpes zoster, or shingles. Immunity can protect against this reactivation. However, as the immune response to VZV wanes, either in the immunocompromised or with age, reactivation can occur. Approximately 1 to 4% of people who get shingles are hospitalized for complication. While there are antivirals that can be effective, acyclovir resistant VZV has been reported in several patient populations, specifically the immunocompromised (HIV/AIDS or transplant recipients).

Technical Summary

Emory scientists have discovered VZV-specific antibodies that can neutralize the virus in vitro. These antibodies are gH-specific and are able to inhibit cell-to-cell spread of the virus in vitro. Most gE-specific mAbs were able to neutralize VZV but required the presence of complement and were unable to block cell-to-cell spread.

Developmental Stage

Pre-clinical development.

Publication: Sullivan, N. L. et al. (2018). J. Virol, 92(14), e00269-18.

Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Utility (parent) United States 16/394,360 4/25/2019     Pending
Tech ID: 18123
Published: 8/19/2019
Category
Therapeutics

Contact
Justin Burns
Assistant Director, Licensing
Emory University
404-727-4968
justin.burns@emory.edu

Inventor(s)
Rafi Ahmed
Nicole Sullivan

Keywords
Antibody
Microbiology/Infectious Diseases