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Cell and Gene Therapies for Hemophagocytic Lymphohistiocytosis
Application Gene/cell therapy to treat hemophagocytic lymphohistiocytosis. Key Benefits Gene therapy approach for treating patients with UNC13D mutated hemophagocytic lymphohistiocytosis. Preliminary in vitro and in vivo data show the ability of the gene therapy to increase UNC13D protein levels and decrease T cell activation. It is administered...
Published: 1/17/2024       Contributor(s): H. (Harold) Trent Spencer, Christopher Doering, Shanmuganathan Chandrakasan, Sarah Takushi
Machine Learning Diagnostic for Automated Identification and Classification of Bone Marrow Cells
Application Assist in the diagnosis of hematologic disorders of bone marrow. Key Benefits Automated machine learning approach for performing bone marrow differential counts that accounts for all viable cells on the smear. Preliminary data generated by a prototype shows the system is fast and demonstrates precision compared to manual counting. Potential...
Published: 1/10/2024       Contributor(s): David Jaye, Lee Cooper, Joshua Lewis, David Gutman
Antisense Oligonucleotides Therapeutics Targeting Specific Tissues or Cells
Application Antisense oligonucleotide (ASO) therapies for the treatment of rare diseases and cancer. Key Benefits Novel approach to ASO therapeutics that potentially improve tissue/cell targeting capabilities. Increases the efficacy of ASOs while decrease off-target toxicity. Potential to treat a variety of genetic diseases such as cancer, blood...
Published: 3/1/2024       Contributor(s): Jiahui Zhang, Khalid Salaita, Hanjoong Jo
Central Line-Associated Bloodstream Infection (CLABSI) Prediction Model
­ Application A predictive model of central line-association bloodstream infection (CLABSI). Key Benefits Specifically designed to improved predictive analysis of patients who are at risk for CLABSI. Scored higher predictive values on average than similar predictive modeling without the hypotheses driven approach (Bidirectional LSTM with...
Published: 7/28/2023       Contributor(s): Azade Tabaie, Rishikesan (Rishi) Kamaleswaran, Evan Orenstein
Additives that Increase Storage and Shelf Life of Platelets
Application Monoclonal antibody additive that inhibits ectodomain shedding of a platelet glycoprotein to improve platelet storage. Key Benefits Current storage techniques allows for limited storage times (5-7 days). New additive may enable platelet storage at 4°C, increase platelet storage time, and improve quality of stored platelets. Inhibits...
Published: 3/11/2024       Contributor(s): Renhao Li
Micron-Sized Drug Vehicle for Unregulated Blood Clotting
Application Fibrinogen-coated micron-sized drug vehicles for targeted treatment of unregulated blood clotting. Key Benefits Facilitates targeted release of drugs specifically for blood clotting disorders. Drug delivery vehicle can be used with newly discovered or known therapeutics on the market. Site specific biological mechanism may help increase...
Published: 3/1/2024       Contributor(s): Caroline Hansen, Yumiko Sakurai, Wilbur Lam, Andrew Lyon
Microfluidic Device Enhances Understanding of Clot Formation
Application A microfluidic device for the measurement and quantification of the mechanical forces that occur during clot formation for use in hematology research or for diagnostic purposes. Key Benefits Is capable of measuring platelet-platelet interactions at the single cell level that is not possible with current tools. Facilitates quick &...
Published: 11/6/2023       Contributor(s): David Myers, Wilbur Lam, Yongzhi Qiu
Algorithm and Software Application for the Diagnosis of Adverse Reactions to Blood Transfusion
Application Web-based and mobile application based on the National Healthcare Safety Network’s Biovigilance Component Hemovigilance Module Surveillance Protocol to aid in the identification of adverse reactions to transfusions easily and accurately. Key Benefits Provides a quick, easy, and accurate method to identify transfusion reactions...
Published: 7/28/2023       Contributor(s): John Roback, Geoffrey Smith
Repurposed Antifibrinolytic Agents as a Substitute for Platelet Transfusions to Prevent Bleeding in Severe Thrombocytopenia Patients
Application Prophylactic administration of an antifibrinolytic agent, epsilon aminocaproic acid (EACA), to prevent bleeding in patients with thrombocytopenia from hematological malignancies. Key Benefits Orally bioavailable, repurposed drug. Commonly used and FDA approved to manage hemorrhage in patients with congenital bleeding. Cheaper and...
Published: 7/28/2023       Contributor(s): Hanna Khoury, Ana Antun
P-selectin Inhibitor for the Treatment of Sickle Cell Disease
Application A glycopeptide inhibitor of p-selectin for the treatment of sickle cell disease. Key Benefits Blocks the activity of P-selectin with nM affinity. Potential treatment for vaso-occlusive crisis associated with sickle cell disease. Inhibits the earliest stage of leukocyte activation helping to prevent immune response. Market Summary Sickle...
Published: 3/11/2024       Contributor(s): Richard Cummings, Elliot Chaikof, Venkata Krishnamurthy, Mohammed Sardar
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