Liposome Encapsulated Tyrosine Kinase Inhibitors to Treat Leukemia
Application
Lipid encapsulation of MRX-2843 for the treatment of leukemia.
Key Benefits
Encapsulation of a tyrosine kinase inhibitor called MRX-2843 within a liposome improves its performance in an animal model of acute lymphoblastic leukemia.
Systemic delivery of this therapeutic requires a lower dose and less frequent administration than oral...
Published: 4/23/2024
Contributor(s): Erik Dreaden, James Kelvin, Deborah DeRyckere, Douglas Graham, Juhi Jain
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Using Hetero-multivalent DNA-functionalized Materials to Detect Genetic Mutations
Application
Improving diagnostic accuracy using hetero-multivalent DNA-functionalized materials for disease targets containing one or more genetic mutations.
Key Benefits
Tunable oligos increase specificity and cooperative binding to the disease target of interest.
Distinguishes between cis- and trans mutations.
Identifies different strains of...
Published: 3/1/2024
Contributor(s): Brendan Deal, Khalid Salaita, Rong Ma, James Kindt
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Implanted Passive Pressure Sensor Interrogated with (Ultra)-Sound (iPPSIS)
Application
Easy-to-use, short and long-term, minimally invasive, MR-safe approach for directly measuring the variation of intracranial pressure.
Key Benefits
A minimally invasive device that is compatible with MRI imaging for quantitatively measuring intracranial pressure.
A prototype has been developed showing the ability to measure shunt pressure...
Published: 3/1/2024
Contributor(s): David Myers, Nicholas Au Yong, Brooks Lindsey, Cecilia Alessandra Luna, Saeyoung (Sunny) Kim, Bowen Jing
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Reagents and Hardware for RNA Storage at Ambient Temperatures
Application
Simple and economical method for isolating and storing RNA from biological samples at room temperatures.
Key Benefits
Alternative, low-cost extraction method suitable for extracting RNA from biological samples for molecular analysis and disease diagnosis.
Eliminates the need for expensive proprietary materials, hazardous chemicals,...
Published: 4/9/2024
Contributor(s): Jesse Waggoner, David Myers, Sarah Hernandez, Dhruv Miglani
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Improving CAR T cell efficacy with Cytokine-Loaded Microparticles
Application
Novel reagents for manufacturing of CAR T cells with improved characteristics.
Key Benefits
A multi-cytokine backpack particle that can be used during manufacturing process of CAR T treatments to improve their phenotype and efficacy.
Preliminary data show the method can transduce primary healthy and patient T cells and promote CAR...
Published: 1/10/2024
Contributor(s): Sarwish Rafiq, Erik Dreaden, A K M Nawshad Hossian, Biaggio Uricoli
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Chameleon-Inspired Strain-Accommodating Smart Skin
Application
A flexible smart skin that changes its color in response to heat or sunlight.
Key Benefits
Strain-accommodating.
Thermal and photothermal responsive.
Light responsive.
Highly stretchable.
Market Summary
Hydrogels are water-insoluble, three-dimensional networks of polymer chains capable of holding large amounts of water. They are...
Published: 12/7/2023
Contributor(s): Khalid Salaita, Yixiao Dong
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Functionalized Collagen Biochips with Core-Shell Structures and Collagen-Mimetic Peptide Nanotubes
Application
Synthetic collagen-based biomaterials for therapeutic delivery or drug testing.
Key Benefits
Synthetic collagen substitute.
Capable of formulating into various structures.
Free of animal-based contaminants.
Able to be spatially patterned.
Market Summary
Organ failure and tissue defects affect millions of Americans, resulting in...
Published: 3/1/2024
Contributor(s): Vincent Conticello, Andrea Merg, Gavin Touponse
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A Method of Using Responsive Micro and Sub-micro Scale Polymer Particles for Mechanical Manipulation of Molecules
Application
A method to study the mechanical/controlled unfolding of biomolecules using a polymer force clamp (PFC).
Key Benefits
Particles can be immobilized onto virtually any type of support.
Particles can also be functionalized with a variety of small-molecule, peptide and protein ligands.
Ability to have multiple PFC’s measuring associated...
Published: 4/23/2024
Contributor(s): Hanquan Su, Khalid Salaita
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Serological Test for SARS-CoV-2
Application
Clinical assay for detecting SARS-CoV-2 neutralizing antibodies.
Key Benefits
Highly specific and sensitive.
Fewer false positives than commercially available tests.
Market Summary
SARS-CoV-2 is currently causing a devastating pandemic and there is a pressing need to understand the dynamics, specificity, and neutralizing...
Published: 12/20/2023
Contributor(s): Rafi Ahmed, Mehul Suthar, John Roback, Jens Wrammert, Robert Kauffman
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tPAINT to Measure Molecular Forces in Live Cells
Application
DNA-based probes to measure the nanoscale distribution of piconewton molecular forces in live cells.
Key Benefits
Provides maps of integrin tension with up to ˜25 nm resolution and piconewton force sensitivity for live-cell imaging.
The tPAINT can be performed on a commercial TIRF microscope.
Market Summary
Emory inventors...
Published: 12/7/2023
Contributor(s): Joshua Brockman, Hanquan Su, Khalid Salaita
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