Drug design and development; research.
Crystallography data are commercially used for rational drug design and for experimentally testing interactions of candidate drugs with their targets. The current invention provides the first X-ray crystal structure of a histone methyltransferase, DIM 5. DIM-5 belongs to the family of histone lysine methyltransferases and can profoundly influence gene expression. DIM-5 is also required for DNA methylation, a process often associated with cancer formation in mammals. The structure can serve as a guideline for genetic and biochemical studies of these proteins, and has the potential to greatly accelerate the discovery of new drugs targeted on these proteins.