Mouse model that over expresses tristetraprolin (TTP), also known as zinc finger protein 36 homolog (ZFP36), in fat tissue.
- Useful in the study of functions of high ZFP36 expression in fat tissue of mice, in inflammatory responses, in TNF-alpha production, and as a target for anti-TNF-alpha therapies.
- Model has good reproduction and no special husbandry requirements.
Tristetraprolin (TTP) or zinc finger protein 36 homolog (ZFP36) is a protein that binds to untranslated regions of messenger RNA (mRNA) of some cytokines and promotes their degradation. For example, TTP binds to and destabilizes the mRNA of TNF-alpha, thereby interfering with its production. Mice deficient in TTP develop a complex syndrome of inflammatory diseases. Dr. Kallen has developed a mouse model from the 657 BL/6 strain that has good reproduction and shows overexpression of ZFP36 in fat tissue. ZFP36 overexpression does not mimic human conditions but would be of interest to researchers studying the functions of high ZFP36 expression in fat deposits as well as potential therapies that target TNF-alpha.
Publication: Science. 1998 Aug; 281(5379):1001-1005.