Technology Listings


The Antitussive Drug Noscapine & its Derivatives as Anti-Tumor Agents

Application

Can be used for the treatment of neoplastic disease.

Summary

A variety of chemotherapeutic agents interact with tubulin, the major protein of mitotic spindles, resulting in mitotic arrest and ultimately cell death in rapidly dividing cells. Athough tubulin-targeting agents are capable of arresting cells in mitotis, these drugs indiscriminantly target both neoplastic and healthy cells resulting in toxic side effects. Thus, there is an urgent need to direct research efforts towards developing more specific chemotherapeutic agents.

The Joshi laboratory has identified noscapiane, an opium alkaloid, which arrests a variety of tumor cells in mitosis. Cough suppression was the only pronounced pharmacologic effect of noscapine known for over thirty years until the Joshi lab demonstrated that noscapine: 1) binds to tubulin and alters its conformation and assembly properties; 2) interferes with microtubule dynamics both in vitro and in living cells; 3) arrests a variety of mammalian cells in mitosis and targets them for apoptosis; and 4) oral administration inhibits the growth of murine thymoma, human breast, bladder, and melanoma tumor cells, and murine and human gliolbastoma cells by inducing polyploidy and apoptosis.

In contrast to other microtubule interacting agents such as paclitaxel, nocodazole, and vinblastine, noscapine modifies microtubule dynamics without affecting total tubulin polymer mass in reconstituted systems and without altering the steady-state monomer/polymer equilibrium of microtubule assembly in cells.  In addition, noscapine does not appear to cause the toxic side effects associated with other microtubule targeting agents such as alopecia, diarrhea, nausea, and peripheral neuropathy.

View our Breakfast Club video

Review our Breakfast Club PowerPoint

Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Nationalized PCT - United States United States 09/582,375 6,376,516 7/20/1998 4/23/2002 7/20/2018
PCT PCT PCT/US1998/014979   7/20/1998    
Continuation in Part United States 10/056,913 6,673,814 9/26/2000 1/6/2004 1/25/2022
Tech ID: NCS.05
Published: 6/6/2013
Category
Therapeutics

Contact
Cliff Michaels
Assistant Director
Emory University
404-727-3890
ccmicha@emory.edu

Inventor(s)
Harish Joshi
Judith Kapp
Yong Ke
Fuqiang Liu
Keqiang Ye
Jaren Landen
David Archer
Cheryl Armstrong

Keywords
Oncology
Small Molecule