Technology Listings


Neuroimaging Technique for Early Detection and Diagnosis of Parkinson’s Disease

Application

A quantitative, non-invasive, multi-modal, MRI-based diagnostic for Parkinson's disease.

Key Benefits
  • There is no diagnostic for Parkinson's disease - current blood tests and MRIs rarely reveal abnormalities in patients.
  • Provides a quantitative MRI-based diagnostic as well as potential early (pre-symptomatic) diagnostic tool for Parkinson's disease.
  • Able to quantitatively estimate locus coeruleus volume.
  • Early detection and diagnosis of Alzheimer's Disease is possible as the technology is further refined and developed.
Market Summary

There is currently no diagnostic test that can be used to identify and diagnose Parkinson's disease. Current blood tests and neuroimaging scans rarely reveal abnormalities in patients with Parkinson's disease. In the United States, at least 500,000 people are believed to suffer from Parkinson's disease, and about 50,000 new cases are reported annually. The rates vary from country to country but it is unclear whether this reflects true ethnic or geographic differences or discrepancies in data collection and diagnosis.

Technical Summary

Although the presence of Lewy bodies (which can only be seen during an autopsy) in the brain are regarded as a hallmark of Parkinson's, Lewy bodies are present in a high number of people without diagnosed Parkinson's disease. Autopsies have now uncovered that patients with Parkinson's disease have a profound and early degeneration of the locus coeruleus. The locus coeruleus plays a role in arousal, attention, REM sleep and stress responses that are abnormal in Parkinson's patients. Emory researchers have developed a technique that uses neuromelanin MRI to image the locus coeruleus safely and non-invasively. With this neuromelanin MRI technique, high resolution images are created using a novel scanning algorithm which is applied to estimate locus coeruleus volumes. The new scanning method is optimized to a 3T MRI machine and harness proprietary pulse technology to achieve superior image results. This technique has been applied to 60 subjects.

Developmental Stage

Preliminary study demonstrates a significant decrease in locus coeruleus volume in patients with Parkinson's disease compared to controls and algorithm has been refined.

Presentation: Huddleston, D.E., et al. Movement Disorders 2012;27 Suppl 1 :729

Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
PCT PCT PCT/US2013/030894   3/13/2013   11/4/2014
Nationalized PCT - United States United States 14/395,140 9,600,881 10/17/2014 3/21/2017 3/13/2033
Tech ID: 11187
Published: 8/15/2012
Category
Diagnostics

Contact
Rajsekhar Guddneppanavar
Licensing Associate
Emory University
RGUDDNE@emory.edu

Inventor(s)
Daniel Huddleston
Xiaoping Hu
Sinyeob Ahn
Xiangchuan Chen

Keywords
Imaging
Neuroscience/Pain