Technology Listings


Folate Receptor Expression in Parathyroids: Diagnostic Imaging and Therapeutic Opportunities

Application

Parathyroid imaging and treatment using directed delivery of a noninvasive radiodiagnostic agent.

Key Benefits
  • Improved identification and localization of parathyroid tumors.
  • Increased sensitivity and selectivity in the targeting of parathyroid tissue.
  • May be used to deliver therapeutic agents selectively to malignant parathyroid carcinoma cells.
Technical Summary

Our technology describes the use of technetium 99-m (99mTc) folate to image parathyroid tissue. 99mTc folate binds to folate receptor positive cells and tissues with high affinity. The current standard of parathyroid therapy is first localizing the parathyroid tumor with 99mTc-sestamibi as a radiotracer followed by parathyroid surgery. However current imaging techniques fail to identify the parathyroid tumor in as many as 30% of patients and current imaging modalities fail to localize 10-15% of tumors. The commonly used radiotracer, 99mTc-sestamibi, binds to both parathyroid and thyroid tissue however we found that 99mTc folate binds to parathyroid but not thyroid tissue. In addition, folate receptors are expressed in parathyroid but not thyroid tissue. Because of these differences between parathyroids and thyroids, 99mTc folate may have a considerable advantage in accurately imaging and localizing parathyroid tumors. With increased sensitivity and accuracy in tumor localization, patients will be able to have focal, minimally invasive parathyroidectomies, improved cure rates, improved cosmesis, and shorter hospital stays.

Developmental Stage

Proof of principle study shows that 99mTc folate binds to HeLa cells.

Patent Information
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Nationalized PCT - Foreign Canada 2,880,001   7/24/2013   7/24/2033
Nationalized PCT - Foreign EP 13822731.9   7/24/2013   7/24/2033
Nationalized PCT - United States United States 14/416,694 7/24/2013    
Tech ID: 10168
Published: 4/18/2011
Category
Diagnostics

Contact
Justin Burns
Licensing Associate
Emory University
justin.burns@emory.edu

Inventor(s)
Collin Weber

Keywords
Drug Delivery
Imaging Agents
Oncology