Human Dnmt3L (full-length)
DNA methyltransferase (DNMT) proteins are involved in DNA methylation in which a methyl group is added to a cytosine residue on DNA. Three families of DNMTs have been identified: DNMT1, DNMT2, and DNMT3. The DNMT3 family contains two active methyltransferases, DNMT3A & DNMT3B, and one DNMT3-Like protein (DNMT3L). DNMT3L does not contain amino acids necessary for methyltransferase activity, therefore it likely does not function as a DNA methyltransferase. It is instead believed to stimulate de novo methylation by DNMT3s. The antibody available was purified from rabbit using highly purified native protein as antigen. The dilution of the serum is 1:500 and the dilution of the purified antibodies is 1:5000. Reactivity was tested for both the serum and purified antibodies via dot blot using corresponding antigens.
Publication: Chang et al. Nat Commun. 2011 2:533.